Finanzielle Toxizität bei Krebspatient*innen unter Strahlentherapie

Fabian, Alexander; Rühle, Alexander; Becker, Jan-Niklas; Bockelmann, Elodie; Domschikowski, Justus; Boeke, Simon; Fink, Christoph; Käsmann, Lukas; Sonnhoff, Matthias; Schneider, Melanie; Trommer, Maike; Wegen, Simone; Wurschi, Georg; Krug, David; Nicolay, Nils H.

doi:10.1007/s12312-022-01097-1

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…General population data were used to estimate mortality from natural causes as well as to estimate the loss of income due to treatment. A subgroup of rectal cancer patients from the young DEGRO (German Society of Radiation Oncology) working party multicenter trial "FinTox" [16,20] and its precursor trial [15] were used to control the epidemiologic assumptions from the German general population (see Supplementary Material Figure S1 for the composition of the reference cohort).…”

Section: Methodsmentioning

confidence: 99%

Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer

Wurschi,

Rühle,

Domschikowski

et al. 2024

Cancers

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Total neoadjuvant therapy (TNT) is an evolving treatment schedule for locally advanced rectal cancer (LARC), allowing for organ preservation in a relevant number of patients in the case of complete response. Patients who undergo this so-called “watch and wait” approach are likely to benefit regarding their quality of life (QoL), especially if definitive ostomy could be avoided. In this work, we performed the first cost-effectiveness analysis from the patient perspective to compare costs for TNT with radical resection after neoadjuvant chemoradiation (CRT) in the German health care system. Individual costs for patients insured with a statutory health insurance were calculated with a Markov microsimulation. A subgroup analysis from the prospective “FinTox” trial was used to calibrate the model’s parameters. We found that TNT was less expensive (−1540 EUR) and simultaneously resulted in a better QoL (+0.64 QALYs) during treatment and 5-year follow-up. The average cost for patients under TNT was 4711 EUR per year, which was equivalent to 3.2% of the net household income. CRT followed by resection resulted in higher overall costs for ostomy care, medication and greater loss of earnings. Overall, TNT appeared to be more efficacious and cost-effective from a patient’s point of view in the German health care system.

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Section: Methodsmentioning

confidence: 99%

Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer

Wurschi,

Rühle,

Domschikowski

et al. 2024

Cancers

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“…The questionnaire was paper-based, pilot-tested, and completed anonymously by participating patients. Details of the questionnaire have been described previously [ 17 , 19 ]. The outcome variable of interest for this analysis was patient satisfaction with radiotherapy care.…”

Section: Methodsmentioning

confidence: 99%

“…DRKS00028784, ARO 2022-07). The study design as well as results on financial toxicity and psychosocial distress have been reported previously [17][18][19]. The focus of the present analysis is on patient satisfaction with radiotherapy care.…”

Section: Methodsmentioning

confidence: 99%

Satisfaction with radiotherapy care among cancer patients treated in Germany—secondary analysis of a large multicenter study

Fabian,

Rühle,

Domschikowski

et al. 2023

Strahlenther Onkol

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Purpose Patient satisfaction with healthcare has been linked to clinical outcomes and regulatory agencies demand its regular assessment. Therefore, we aimed to investigate patient satisfaction with radiotherapy care and its determinants. Methods This is a secondary analysis of a multicenter prospective cross-sectional study. Eligible cancer patients anonymously completed questionnaires at the end of a course of radiotherapy. The outcome variable was overall patient satisfaction with radiotherapy care measured with a 10-point Likert scaled single-item. Given patient satisfaction was defined for patients scoring ≥ 8 points. Determinants of given patient satisfaction were assessed by univariable and multivariable analyses. A p-value < 0.05 was considered statistically significant. Results Out of 2341 eligible patients, 1075 participated (participation rate 46%). Data on patient satisfaction was provided by 1054 patients. There was a right-skewed distribution towards more patient satisfaction (mean = 8.8; SD = 1.68). Given patient satisfaction was reported by 85% (899/1054) of the patients. Univariable analyses revealed significant associations of lower patient satisfaction with tumor entity (rectal cancer), concomitant chemotherapy, inpatient care, treating center, lower income, higher costs, and lower quality of life. Rectal cancer as tumor entity, treating center, and higher quality of life remained significant determinants of patient satisfaction in a multivariable logistic regression. Conclusion Overall patient satisfaction with radiotherapy care was high across 11 centers in Germany. Determinants of patient satisfaction were tumor entity, treating center, and quality of life. Although these data are exploratory, they may inform other centers and future efforts to maintain high levels of patient satisfaction with radiotherapy care.

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Psychosocial distress in cancer patients undergoing radiotherapy: a prospective national cohort of 1042 patients in Germany

Fabian¹,

Rühle²,

Domschikowski³

et al. 2023

J Cancer Res Clin Oncol

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Purpose Psychosocial distress is common among cancer patients in general, but those undergoing radiotherapy may face specific challenges. Therefore, we investigated the prevalence and risk factors for distress in a large national cohort. Methods We performed a secondary analysis of a multicenter prospective cross-sectional study which surveyed cancer patients at the end of a course of radiotherapy using a patient-reported questionnaire. Distress was measured with the distress thermometer (DT), using a cut-off of ≥ 5 points for clinically significant distress. Univariate analyses and multivariate multiple regression were used to assess associations of distress with patient characteristics. A two-sided p-value < 0.05 was considered statistically significant. Results Out of 2341 potentially eligible patients, 1075 participated in the study, of which 1042 completed the DT. The median age was 65 years and 49% (511/1042) of patients were female. The mean DT score was 5.2 (SD = 2.6). Clinically significant distress was reported by 63% (766/1042) of patients. Of the patient characteristics that were significantly associated with distress in the univariate analysis, a lower level of education, a higher degree of income loss, lower global quality of life, and a longer duration of radiotherapy in days remained significantly associated with higher distress in the multivariate analysis. Yet effect sizes of these associations were small. Conclusion Nearly two in three cancer patients undergoing radiotherapy reported clinically significant distress in a large multicenter cohort. While screening and interventions to reduce distress should be maintained and promoted, the identified risk factors may help to raise awareness in clinical practice. Trial Registry identifier DRKS: German Clinical Trial Registry identifier: DRKS00028784.

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Finanzielle Toxizität bei Krebspatient*innen unter Strahlentherapie

Cited by 4 publications

References 14 publications

Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer

Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer

Satisfaction with radiotherapy care among cancer patients treated in Germany—secondary analysis of a large multicenter study

Psychosocial distress in cancer patients undergoing radiotherapy: a prospective national cohort of 1042 patients in Germany

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