Financial toxicity following surgical treatment for colorectal cancer: a cross-sectional study

Mo, Minghui; Jia, Peipei; Zhu, Kai; Huang, Wenjing; Han, Li; Liu, Cuiping; Huang, Xia

doi:10.1007/s00520-022-07572-8

Cited by 21 publications

(24 citation statements)

References 58 publications

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“…Four studies included EOCRC patients only, with two of these including only patients under the age of 40 years 8 , 15 , 19 , 21 . The remaining studies included both EOCRC and LOCRC patients, but with varying cut-off ages for their age comparison analysis, with some under 40 14 , 24 , under 45 25 , or under 50 years 13 , 16 , 18 , 20 , 23 , 26 . Studies were mainly from English-speaking countries with eight from the USA 8 , 13 , 14 , 19 , 20 , 22 , 24 , 26 .…”

Section: Resultsmentioning

confidence: 99%

“…Studies were mainly from English-speaking countries with eight from the USA 8 , 13 , 14 , 19 , 20 , 22 , 24 , 26 . Other studies from predominantly non-English-speaking countries were from Israel 15 , the Netherlands 25 , Iran 16 , 17 , Japan 18 , and China 23 , and one was a multinational collaboration 21 ( Fig. 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Five studies gave some insight into the impact on patients’ financial well-being and careers 8 , 15 , 23–25 ( Table 4 ). The negative effects on financial well-being and career are significant for all people diagnosed with CRC; however, these effects may be more pronounced in EOCRC patients when compared with older patients.…”

Section: Resultsmentioning

confidence: 99%

“…A study 23 that measured non-metastatic CRC patients’ levels of financial toxicity, using the comprehensive score for financial toxicity (COST) 29 , found that younger age was associated with higher levels of financial toxicity. Of patients under 50 years, 90 per cent scored as having a high level of financial distress; this proportion dropped substantially in the older age groups (age 50–64 years, 54 per cent; age 65–74 years, 40 per cent; and age greater than or equal to 75 years, 19 per cent ( P ≤ 0.001)) 23 .…”

Section: Resultsmentioning

confidence: 99%

“…Financial and career stresses are more common in younger cancer patients compared with older patients. Up to 90 per cent of EOCRC patients are found to report significant financial toxicity 23 . Some studies surveying multiple QOL domains found that the largest differences between young and old patients were found in stress around financial difficulties and social functioning 46 .…”

Section: Discussionmentioning

confidence: 99%

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Quality of life in early-onset colorectal cancer patients: systematic review

Waddell

Mclauchlan²,

McCombie

et al. 2023

BJS Open

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Background There is an increasing incidence of early-onset colorectal cancer; however, the psychosocial impacts of this disease on younger adults have been seldom explored. Methods A systematic review was conducted according to the PRISMA guidelines. The Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, PubMed, and Scopus were searched, and papers were included if published in English within the last 10 years and if they reported results separately by age (including early-onset colorectal cancer, defined as colorectal cancer diagnosed before the age of 50 years). Critical appraisal of all studies was done using the Joanna Briggs Institute tools. The primary outcome of interest was the global quality of life in patients with early-onset colorectal cancer. Secondary outcomes included the effect on sexual function, body image, finances, career, emotional distress, and social and family functioning. Results The search yielded 168 manuscripts and 15 papers were included in the review after screening. All studies were observational, and included a total of 18 146 patients, of which 5015 were patients with early-onset colorectal cancer. The studies included scored highly using Joanna Briggs Institute critical appraisal tools, indicating good quality and a low risk of bias, but data synthesis was not performed due to the wide range of scoring systems that were used across the studies. Six papers reported significant negative impacts on quality of life in patients with early-onset colorectal cancer. Three of the four studies that compared the quality of life in patients with early-onset colorectal cancer with older patients found that the younger group had worse mean quality-of-life scores (P ≤ 0.05). Secondary outcomes measured in five studies in relation to sexual dysfunction, body image, financial and career impacts, and social and family impacts and in eight studies in relation to emotional distress were found to be more severely impacted in those with early-onset colorectal cancer compared with those with late-onset colorectal cancer. Conclusion Whilst data are limited, the impact of colorectal cancer is different in patients with early-onset colorectal cancer compared with older patients in relation to several aspects of the quality of life. This is particularly prominent in areas of global quality of life, sexual functioning, family concerns, and financial impacts.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Quality of life in early-onset colorectal cancer patients: systematic review

Waddell

Mclauchlan²,

McCombie

et al. 2023

BJS Open

View full text Add to dashboard Cite

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Determination of a cut-off COmprehensive Score for financial Toxicity (COST) for identifying cost-related treatment nonadherence and impaired health-related quality of life among Chinese patients with cancer

Xu,

So,

Choi

2024

Support Care Cancer

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Purpose This study aimed to determine a cut-off for the simplified Chinese version of the COmprehensive Score for financial Toxicity (COST) that could identify cost-related treatment nonadherence among Chinese patients with cancer. The study also sought to validate this cut-off score by using it to assess impaired health-related quality of life (HRQoL) in the same population. Methods A secondary analysis was conducted using data from a cross-sectional survey of 1208 Chinese patients with cancer who were recruited from 12 hospitals in six cities across three provinces of the Chinese mainland. Sociodemographic information and data on financial toxicity (FT), cost-related treatment nonadherence, and HRQoL were used in the analysis. Receiver operating characteristic (ROC) analysis was used to determine the optimal cut-off for the simplified Chinese version of the COST. Results The ROC analysis identified a COST cut-off of 18.5 for identifying cost-related treatment nonadherence, yielding a sensitivity of 76.5% and specificity of 71.4%. In the validation study, this cut-off score yielded a sensitivity of 64.2% and a specificity of 67.1% for identifying impaired HRQoL. Conclusion Early and dynamic assessment of cancer-related FT in routine clinical practice may play a crucial role in the early identification and management of FT. Accordingly, a COST cut-off of 18.5 was identified to indicate cost-related treatment nonadherence and impaired HRQoL in a population of patients with cancer from the Chinese mainland. This finding may facilitate the implementation of universal FT screening among patients with cancer in specific settings such as the Chinese mainland.

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