Laparoscopic liver resection (LLR) is safe, feasible and is rapidly gaining acceptance. Indications for LLR are symptomatic benign lesions, adenomas > 4 cm, giant hepatic cysts, and well-selected hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC) tumors. Bene藲ts of LLR include smaller incisions, less estimated blood loss (EBL) and packed red blood cell (pRBC) transfusions, less postoperative pain, shorter length of stay, and decreased postoperative morbidity compared to open hepatic resection. Long-term oncologic outcomes for HCC or limited mCRC are comparable when comparing LLR to open liver resection in case-cohort matched studies.Laparoscopic liver resection is rapidly being adopted for certain benign and malignant tumors with more than 6000 cases performed worldwide.