Final Report on the Safety Assessment of Sodium Cetearyl Sulfate and Related Alkyl Sulfates as Used in Cosmetics

Abstract

Sodium cetearyl sulfate is the sodium salt of a mixture of cetyl and stearyl sulfate. The other ingredients in this safety assessment are also alkyl salts, including ammonium coco-sulfate, ammonium myristyl sulfate, magnesium coco-sulfate, sodium cetyl sulfate, sodium coco/hydrogenated tallow sulfate, sodium coco-sulfate, sodium decyl sulfate, sodium ethylhexyl sulfate, sodium myristyl sulfate, sodium oleyl sulfate, sodium stearyl sulfate, sodium tallow sulfate, sodium tridecyl sulfate, and zinc coco-sulfate. These ingredients are surfactants used at concentrations from 0.1% to 29%, primarily in soaps and shampoos. Many of these ingredients are not in current use. The Cosmetic Ingredient Review (CIR) Expert Panel previously completed a safety assessment of sodium and ammonium lauryl sulfate. The data available for sodium lauryl sulfate and ammonium lauryl sulfate provide sufficient basis for concluding that sodium cetearyl sulfate and related alkyl sulfates are safe in the practices of use and concentration described in the safety assessment.

Injectable silk-polyethylene glycol hydrogels

“…However, toxicity of these chemicals is a significant concern for medical applications. To achieve rapid gelation within 30 min, greater than 50% alcohol and 1% sodium dodecyl sulfate (SDS) usually needs to be added to silk solution, which is above the tolerance level (<10% alcohol for intravenous injection and <1% SDS for skin and ocular formulations) for human use [16,17]. These chemical mixing methods have therefore been restricted to silk gelation mechanisms or tissue repairs using gel implants after extraction of these chemicals.…”

Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota

“…Sodium lauryl sulfate (SLS) is a widely used surfactant in cleansing products, cosmetics at dose ranging from 0.01 to 50% [10] and personal care products [11,12]. SLS is an anionic surfactant which distorts cell membrane proteins [13].…”

Allergic contact dermatitis caused by sodium cetearyl sulfate

“…It was found in 111 products at concentrations of 0.1–10%. It was classified as a safe product for the skin: not irritant or sensitizing . It is thought that its ‘safe profile’ is related to the polyethoxylation of the fatty alcohols .…”