“…5,10,18–20 Previous studies have examined the effect of different physical properties and smoking regimens on the levels and toxicity of the MSS HPHCs across different brands of cigarettes. 3,10,19,33,42,43,45,46 To understand how these variables in cigarettes are different from little cigars, we compared the physical properties of the most popular little cigars 27,28 with the 3R4F. Our results showed that each of the selected little cigars are longer (~15 mm), and therefore, hold more tobacco mass (100–200 mg), than the 3R4F.…”