Final Products of One-Electron Oxidation of Cyclic Dipeptides Containing Methionine Investigated by IRMPD Spectroscopy: Does the Free Radical Choose the Final Compound?
Abstract:Reactive oxygen species (ROS) such as hydrogen peroxide
(H2O2) and the hydroxyl radical (•OH) have specific functions in biological processes, while their
uncontrolled production and reactivity are known to be determining
factors in pathophysiology. Methionine (Met) residues act as endogenous
antioxidants, when they are oxidized into methionine sulfoxide (MetSO),
thus depleting ROS and protecting the protein. We employed tandem
mass spectrometry combined with IR multiple photon dissociation spectroscopy
to stu… Show more
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