Aerothermodynamics, encompassing aerodynamics, aeroheating, and fluid dynamics and physical processes, is the genesis for the design and development of advanced space transportation vehicles and provides crucial information to other disciplines such as structures, materials, propulsion, avionics, and guidance, navigation and control. Sources of aerothermodynamic information are ground-based facilities, Computational Fluid Dynamic (CFD) and engineering computer codes, and flight experiments. Utilization of this aerothermodynamic triad provides the optimum aerothermodynamic design to safely satisfy mission requirements while reducing design conservatism, risk and cost. The iterative aerothermodynamic process for initial screening/assessment of aerospace vehicle concepts, optimization of aerolines to achieve/exceed mission requirements, and benchmark studies for final design and establishment of the flight data book are reviewed. Aerothermodynamic methodology centered on synergism between ground-based testing and CFD predictions is discussed for various flow regimes encountered by a vehicle entering the Earth's atmosphere from low Earth orbit. An overview of the resources/infrastructure required to provide accuratekreditable aerothermodynamic information in a timely manner is presented. Impacts on Langley's aerothermodynamic capabilities due to recent programmatic changes such as Center reorganization, downsizing, outsourcing, industry (as opposed to NASA) led programs, and so forth are discussed. Sample applications of these capabilities to high