Background: Dermestes maculatus is a destructive pest of smoked-dried fish. Due to its implications, this research was aimed at investigating the insecticidal activities of edible plant extracts on smoked Clarias gariepinus as protectants against Dermestes maculatus. Result: The extract of Piper guineense at 4%, 8%, and 12% concentrations recorded between 8-92% and 33-100% mortalities, respectively, for the first 4 weeks and 0% mortality was observed in weeks 5-8. The extracts of Capsicum frutescens and Dennettia tripetala at 4% concentration recorded between 8 and 92% mortalities in the first 4 weeks and 5 weeks, respectively, and no mortality was recorded in the remaining weeks. At 12% concentration for Dennettia tripetala extract, 8-100% mortality was recorded throughout the experimental period. At 12% concentration for Capsicum frutescens, 8-92% mortality was recorded in weeks 1-7 and 0% in week 8. Positive control recorded 33-67% mortality in weeks 1-4 and 0% mortality in weeks 5-8. Negative control recorded no mortality in the first 3 weeks, but few larvae were found dead in the remaining weeks. The mean value of 106, 36, and 96 progenies emerged at 4%, 8%, and 12% concentrations, respectively, in the smoked fish treated with Piper guineense. Mean value of 0.50 and 0.50 progenies were recorded at 4% and 8% concentrations, respectively, while no emergence was observed at 12% concentration of Dennettia tripetala extract. Extract of Capsicum frutescens recorded mean value of 1.00, 3.00, and 3.50 progenies at 4%, 8%, and 12% concentrations, respectively. Weight loss of 66.47%, 31.46%, and 56.25% at 4%, 8%, and 12% concentrations was observed for Piper guineense extract respectively. Extracts of Dennettia tripetala and Capsicum frutescens recorded weight loss of 3.46%, 2.11%, and 0.02% and 27.77%, 12.30%, and 22.90%, respectively, at 4%, 8%, and 12% concentrations. Positive and negative controls recorded 4.36% and 81.18% weight loss, respectively. Conclusion: They can therefore serve as affordable substitutes for synthetic chemicals which had been proven to be detrimental to the health of its consumers.