“…The term " reabsorption uremia" was used for the first time by Ferro-Luzzi (7) and was employed in a larger sense by Popper and Mandel (25). Yamaguchi (43) defines the action of the tubules not as active reabsorption but as a selective inhibition of the complete reabsorption.…”
Section: Compensation and Reabsorption Uremiamentioning
confidence: 99%
“…Popper and Mandel (25) were the first to apply this method for the determination of glomerular filtration extensively. Only comparatively few previous publications have appeared on the determination of the endogenous creatinine clearance (9,12,13,18).…”
“…The term " reabsorption uremia" was used for the first time by Ferro-Luzzi (7) and was employed in a larger sense by Popper and Mandel (25). Yamaguchi (43) defines the action of the tubules not as active reabsorption but as a selective inhibition of the complete reabsorption.…”
Section: Compensation and Reabsorption Uremiamentioning
confidence: 99%
“…Popper and Mandel (25) were the first to apply this method for the determination of glomerular filtration extensively. Only comparatively few previous publications have appeared on the determination of the endogenous creatinine clearance (9,12,13,18).…”
“…SCr concentration is the best known and most commonly used marker for estimation of GFR, since it was first described as a GFR marker in 1937 [21] , and SCr analysis is inexpensive and generally accessible.…”
Kidney transplantation is the treatment of choice for endstage renal disease. The evaluation of graft function is mandatory in the management of renal transplant recipients. Glomerular filtration rate (GFR), is generally considered the best index of graft function and also a predictor of graft and patient survival. However GFR measurement using inulin clearance, the gold standard for its measurement and exogenous markers such as radiolabeled isotopes ( 51 Cr EDTA, 99m
“…Creatinine clearance )ther substances were examined as subthus overestimates GFR and particularly so in or inulin and in 1937 Popper & Mapdel subjects who most need precise evaluation of renal I endogenous creatinine which is con-function. A second problem is that the original introduced at a constant rate into the blood alkaline picrate method of Jaffe does not measure t was hoped that the low concentration of creatinine only but also many other substances.…”
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