Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation

Abstract

cLaren RE. Filtration of short-wavelength light provides therapeutic benefit in retinitis pigmentosa caused by a common rhodopsin mutation.

Comment on: ‘Sector retinitis pigmentosa caused by mutations of the RHO gene’

“…We observed a significant structural and functional benefit as a result of this intervention ( Fig. 1) [5].…”

“…p.P180A) as a result of occupational exposure to high intensities of light [4]. We recently investigated the effect of filtration of short-wavelength light using red optical filters on disease progression in the rhodopsin p.P23H knock-in mouse model of sector RP [5]. We hypothesised that reducing exposure of rod photoreceptors to frequencies of light to which they are maximally sensitive might achieve a treatment effect whilst still allowing for useful vision.…”

Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa

“…The effect on retinal structure and function was determined longitudinally in vivo by spectral domain optical coherence tomography (SD-OCT)/confocal scanning laser ophthalmoscopy (cSLO) and ERG respectively. The effect of sham injection had been determined using an identical protocol in a previous study in which a slight reduction in SD-OCT photoreceptor layer (PRL) thickness (defined as the vertical distance between the outer plexiform layer and RPE bands 37 ) and ERG signal was observed in sham-injected relative to fellow uninjected eyes attributable to the surgical procedure 23 . Treatment here with low dose AAV-M3.M5 H .RHO M3/5R by contrast resulted in a significant slowing of retinal degeneration in the Nrl.GFP/+, Rho P23H/+ mouse as recorded by SD-OCT (Fig.…”

Response to Comment on: Sector retinitis pigmentosa caused by mutations of the RHO gene

“…In their recent study, Orlans et al found that retinal degeneration in RhoP23H/+ mice was significantly slower when the mice were housed in red-tinted cages than in untinted cages [2]. Some studies have also shown that retinal damage in rhodopsin-related RP animal models was more sensitive to light and that the progression of retinal degeneration was slower in dark environments [3,4].…”