Filter-less submicron hydrodynamic size sorting

Fouet, Marc; Mader, Maud-Alix; Iraïn, Sabri; Yanha, Zineb; Naillon, Antoine; Cargou, Sébastien; Gué, Anne Marie; Joseph, Pierre

doi:10.1039/c5lc00941c

Cited by 20 publications

(14 citation statements)

References 38 publications

(52 reference statements)

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“…The step which connects microchannel and nanoslits (see inset figure 1) could actually lead to a similar behaviour when beads cross this interface. If we neglect diffusion, beads whose mass center is on a streamline in the microchannel will stay on this streamline inside the nanoslit, except if the streamline distance to the top wall is lower than beads radius, in an analogous way as for hydrodynamic filtration [5,30,35]. This specific geometry and the finite size of objects let beads cross the streamlines when they are tightened at the entrance of the nanoslits [31,34].…”

Section: A Mean Velocity: Two Regimesmentioning

confidence: 99%

Transport of nano-objects in narrow channels: influence of Brownian diffusion, confinement and particle nature

Liot¹,

Socol²,

García³

et al. 2018

J. Phys.: Condens. Matter

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This paper presents experimental results about transport of dilute suspensions of nano-objects in silicon-glass micrometric and sub-micrometric channels. Two kinds of objects are used: solid, rigid latex beads and spherical capsule-shaped, soft polymersomes. They are tracked using fluorescence microscopy. Three aspects are studied: confinement (ratio between particle diameter and channel depth), Brownian diffusion and particle nature. The aim of this work is to understand how these different aspects affect the transport of suspensions in narrow channels and to understand the different mechanisms at play. Concerning the solid beads we observe the appearance of two regimes, one where the experimental mean velocity is close to the expected one and another where this velocity is lower. This is directly related to a competition between confinement, Brownian diffusion and advection. These two regimes are shown to be linked to the inhomogeneity of particles distribution in the channel depth, which we experimentally deduce from velocity distributions. This inhomogeneity appears during the entrance process into the sub-micrometric channels, as for hydrodynamic separation or deterministic lateral displacement. Concerning the nature of the particles we observed a shift of transition towards the second regime likely due to the relationships between shear stress and polymersomes mechanical properties which could reduce the inhomogeneity imposed by the geometry of our device.

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Section: A Mean Velocity: Two Regimesmentioning

confidence: 99%

Transport of nano-objects in narrow channels: influence of Brownian diffusion, confinement and particle nature

Liot¹,

Socol²,

García³

et al. 2018

J. Phys.: Condens. Matter

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show abstract

“…Instead, these methods depend on the inherent differences of the samples (e.g., size, shape, compressibility). Samples can be sorted by using inertial force , hydrodynamic spreading , filtration , and deterministic lateral displacement . Passive sorting does not require bulky and costly equipments such as power amplifiers or pressure controllers, which makes them easily integrated into a portable device.…”

Section: Flow Control In Microfluidic Flow Cytometrymentioning

confidence: 99%

New advances in microfluidic flow cytometry

Gong

Fan

et al. 2018

Electrophoresis

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In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer can benefit the health care in underserved areas such as Africa or Asia. In this article, we review recent advancements of microfluidics including sample pumping, focusing and sorting, novel detection approaches, and data analysis in the field of flow cytometry. The challenge of microfluidic flow cytometry is also examined briefly.

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“…Microfluidic devices have emerged as a viable platform for particle manipulation using magnetic, [ 33 ] optoelectronic, [ 34 ] plasmonic, [ 35 ] electrokinetic, [ 36 ] and hydrodynamic [ 37 ] forces. Applying these principles at the nanoscale instead of the microscale, however, can result in far smaller force magnitudes, poor separation efficiency, and channel clogging.…”

Section: Introductionmentioning

confidence: 99%

Massively Multiplexed Submicron Particle Patterning in Acoustically Driven Oscillating Nanocavities

Tayebi

O’Rorke

Wong

et al. 2020

Small

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high-throughput particle manipulation for preparation, enrichment, and quality control. For example, the size distribution of synthesized nanoparticle catalysts determines their catalysis efficiency. [7,8] In biomedical applications, exosomes, which are submicron extracellular vesicles [9][10][11] containing DNA, microRNAs, and proteins, are a potential source of diagnostic biomarkers. [12][13][14][15] Suitable nanoparticle manipulation tools would enable sizebased sorting/filtering, or manipulation toward downstream activities such as multiplexed diagnostics, nanoelectronic/ robotic constructions, [16,17] and nanoparticle-based drug delivery systems. [18] Conventional particle separation techniques [19] are based on differential density and size, e.g., ultracentrifugation, [20] ultrafiltration, [21] and size exclusion chromatography. [22] Although impressive progress has been made in the last decade, many nanoparticle manipulation tools suffer from high cost, low throughput, and specimen damage. [23][24][25] Scalable nano-and submicron particle patterning has thus traditionally relied on self-assembly methods [26] or oligomer templating [27] however, these are largely unable to produce deterministic singlenanoparticle positioning, they are irreversible, and they require specific reagents or lengthy processing. [28][29][30] Moreover, drug delivery systems which incorporate efficient nanoparticle concentration are creating new avenues for cancer treatment. [31,32] There is, therefore, a pressing need to develop a fast, precise, and scalable method for nano-and submicron scale manipulation.Microfluidic devices have emerged as a viable platform for particle manipulation using magnetic, [33] optoelectronic, [34] plasmonic, [35] electrokinetic, [36] and hydrodynamic [37] forces. Applying these principles at the nanoscale instead of the microscale, however, can result in far smaller force magnitudes, poor separation efficiency, and channel clogging. [38] Furthermore, most of these manipulation methods are constrained by their dependence on particle polarizability, the need for low conductivity medium (which is often not biocompatible), and heating of the surrounding fluid. Optical tweezers [39,40] provide the highest degree of spatial resolution but they are usually applied in static fluids, owing to the relatively small forces that can be generated, [41] and only small numbers of nanoparticles can be manipulated at any one time (those within the Nanoacoustic fields are a promising method for particle actuation at the nanoscale, though THz frequencies are typically required to create nanoscale wavelengths. In this work, the generation of robust nanoscale force gradients is demonstrated using MHz driving frequencies via acoustic-structure interactions. A structured elastic layer at the interface between a microfluidic channel and a traveling surface acoustic wave (SAW) device results in submicron acoustic traps, each of which can trap individual submicron particles. The acoustically driven deformation of nanocavities gi...

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Filter-less submicron hydrodynamic size sorting

Cited by 20 publications

References 38 publications

Transport of nano-objects in narrow channels: influence of Brownian diffusion, confinement and particle nature

Transport of nano-objects in narrow channels: influence of Brownian diffusion, confinement and particle nature

New advances in microfluidic flow cytometry

Massively Multiplexed Submicron Particle Patterning in Acoustically Driven Oscillating Nanocavities

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