Filling in the Visual Gaps: Shifting Cortical Activity using Current Steering

Meikle, Sabrina J.; Hagan, Maureen A.; Price, Nicholas S. C.; Wong, Yan T.

doi:10.1109/embc46164.2021.9629693

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The copyright holder for this preprint this version posted January 1, 2024. ; https://doi.org/10.1101/2024.01.01.573814 doi: bioRxiv preprint applications, particularly in the field of neuroprosthetics [9][10][11]. For example, in visual cortical prosthetics, intracortical microstimulation (ICMS) delivered through implanted probes in the visual cortex has been extensively used to investigate evoked neural responses [12][13][14], animal behaviors [15][16][17][18], and even restore some aspects of visual perception and perceived visual experiences in human subjects [19][20][21][22][23]. These studies not only provide new insights into the electrophysiological properties of cortical networks but also underscore the need for additional studies to enable successful applications of future visual prosthetic devices.…”

Section: Introductionmentioning

confidence: 99%

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Suematsu,

Vazquez,

Kozai

2024

Preprint

View full text Add to dashboard Cite

Objective. Intracortical microstimulation can be an effective method for restoring sensory perception in contemporary brain-machine interfaces. However, the mechanisms underlying better control of neuronal responses remain poorly understood, as well as the relationship between the neuronal activity and other concomitant phenomena occurring around the stimulation site. Approach. Different microstimulation frequencies were investigated in vivo on Thy1-GCaMP6s mice using widefield and two-photon imaging to evaluate the evoked excitatory neural responses across multiple spatial scales as well as the induced hemodynamic responses. Specifically, we quantified stimulation-induced neuronal excitation and silencing in the mouse visual cortex and measured hemodynamic oxyhemoglobin and deoxyhemoglobin signals using mesoscopic-scale widefield imaging. Main results. Our calcium imaging findings revealed a preference for lower-frequency stimulation in neuronal excitation. Hemodynamic signals exhibited a similar distance threshold to the neuronal calcium signals with the oxyhemoglobin concentration around the stimulation site remaining elevated after the stimulation train ended. Somatic and neuropil calcium responses measured by two-photon microscopy showed similar dependence on stimulation parameters, although the magnitudes differed significantly. Furthermore, higher-frequency stimulation induced soma-dominant excitation without silencing. Significance. These results suggest that the mechanism underlying silencing differs from the excitation, requiring ample oxygen supply, and affecting neurons. Our findings provide a novel understanding of evoked excitatory neuronal activity induced by intracortical stimulation and offer insights into neuro-devices that utilize both excitation and silencing phenomena to achieve desired neural responses.

show abstract

Section: Introductionmentioning

confidence: 99%

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Suematsu,

Vazquez,

Kozai

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…They have also shown promising results in neuroengineering applications, particularly in the field of neuroprosthetics [9][10][11]. For example, in visual cortical prosthetics, intracortical microstimulation (ICMS) delivered through implanted probes in the visual cortex has been extensively used to investigate evoked neural responses [12][13][14], animal behaviors [15][16][17][18], and even restore some aspects of visual perception and perceived visual experiences in human subjects [19][20][21][22][23]. In terms of the downside of penetrating microelectrodes, the longevity of recording and stimulation performance [24] and the potentially linked tissue reactions like gliosis around electrodes [25] have been explored.…”

Section: Introductionmentioning

confidence: 99%

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Suematsu,

Vazquez,

Kozai

2024

J. Neural Eng.

View full text Add to dashboard Cite

Objective.Intracortical microstimulation can be an effective method for restoring sensory perception in contemporary brain-machine interfaces. However, the mechanisms underlying better control of neuronal responses remain poorly understood, as well as the relationship between neuronal activity and other concomitant phenomena occurring around the stimulation site. Approach. Different microstimulation frequencies were investigated in vivo on Thy1-GCaMP6s mice using widefield and two-photon imaging to evaluate the evoked excitatory neural responses across multiple spatial scales as well as the induced hemodynamic responses. Specifically, we quantified stimulation-induced neuronal activation and depression in the mouse visual cortex and measured hemodynamic oxyhemoglobin and deoxyhemoglobin signals using mesoscopic-scale widefield imaging.Main results.Our calcium imaging findings revealed a preference for lower-frequency stimulation in driving stronger neuronal activation. A depressive response following the neural activation preferred a slightly higher frequency stimulation compared to the activation. Hemodynamic signals exhibited a comparable spatial spread to neural calcium signals. Oxyhemoglobin concentration around the stimulation site remained elevated during the post-activation (depression) period. Somatic and neuropil calcium responses measured by two-photon microscopy showed similar dependence on stimulation parameters, although the magnitudes measured in soma was greater than in neuropil. Furthermore, higher-frequency stimulation induced a more pronounced activation in soma compared to neuropil, while depression was predominantly induced in soma irrespective of stimulation frequencies. Significance. These results suggest that the mechanism underlying depression differs from activation, requiring ample oxygen supply, and affecting neurons. Our findings provide a novel understanding of evoked excitatory neuronal activity induced by intracortical microstimulation and offer insights into neuro-devices that utilize both activation and depression phenomena to achieve desired neural responses.

show abstract

Filling in the Visual Gaps: Shifting Cortical Activity using Current Steering

Cited by 2 publications

References 23 publications

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Contact Info

Product

Resources

About