Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Crawford, James J.; Feng, Jianwen; Brightbill, Hans; Johnson, Adam R.; Wright, Matthew; Kolesnikov, Aleksandr; Lee, Wendy; Castanedo, Georgette; Do, Steven; Blaquière, Nicole; Staben, Steven T.; Chiang, Po‐Chang; Fan, Peter W.; Baumgardner, Matt; Wong, Susan; Godemann, Robert; Grabbe, Alice; Wiegel, Catharina; Sujatha-Bhaskar, Swathi; Hymowitz, S.G.; Liau, Nicholas P. D.; Hsu, Peter L.; McEwan, Paul; Ismaili, Moulay Hicham Alaoui; Landry, Matthew L.

doi:10.1016/j.bmcl.2023.129277

Bioorganic & Medicinal Chemistry Letters

2023

DOI: 10.1016/j.bmcl.2023.129277

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

James J. Crawford¹,

Jianwen Feng²,

Hans Brightbill³

et al.

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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

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et al. 2024

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Cited by 1 publication

References 35 publications

Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK)

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