Filgrastim desensitization in a patient with Hodgkin lymphoma

Jeter, Hannah; Grisanti, Kathleen; Jantz, Amelia; Wadhwa, Aman; Waite, Emily

doi:10.1002/pbc.29394

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Despite the concentration for testing these molecules being known, as shown in Table 2, the scarcity of documented reactions may have impeded the ability to draw definitive conclusions regarding the safety of skin testing, which may explain the lack thereof in the rest of the cases. Furthermore, it is worth noting the existence of alternative methods of evaluation of hypersensitivity reactions mentioned in Table 1, such as baseline serum tryptase [92,94,99], total IgE [83], and c-KIT [99], but they may have limited impact on further therapeutic approaches given their lack of demonstrated usefulness in these specific contexts.…”

Section: Immediate Reactionsmentioning

confidence: 99%

Balancing Benefits and Risks: A Literature Review on Hypersensitivity Reactions to Human G-CSF (Granulocyte Colony-Stimulating Factor)

Bumbăcea,

Udrea,

Ali

et al. 2024

IJMS

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Human granulocyte colony-stimulating factor (G-CSF) is a granulopoietic growth factor used in the treatment of neutropenia following chemotherapy, myeloablative treatment, or healthy donors preparing for allogeneic transplantation. Few hypersensitivity reactions (HRs) have been reported, and its true prevalence is unknown. We aimed to systematically characterize G-CSF-induced HRs while including a comprehensive list of adverse reactions. We reviewed articles published before January 2024 by searching in the PubMed, Embase, Cochrane Library, and Web of Science databases using a combination of the keywords listed, selected the ones needed, and extracted relevant data. The search resulted in 68 entries, 17 relevant to our study and 7 others found from manually searching bibliographic sources. A total of 40 cases of G-CSF-induced HR were described and classified as immediate (29) or delayed (11). Immediate ones were mostly caused by filgrastim (13 minimum), with at least 9 being grade 5 on the WAO anaphylaxis scale. Delayed reactions were mostly maculopapular exanthemas and allowed for the continuation of G-CSF. Reactions after first exposure frequently appeared and were present in at least 11 of the 40 cases. Only five desensitization protocols have been found concerning the topic at hand in the analyzed data. We believe this study brings to light the research interest in this topic that could benefit from further exploration, and propose regular updating to include the most recently published evidence.

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