Filgrastim and Pegfilgrastim Use in Patients With Neutropeni

Quirion, Eva

doi:10.1188/09.cjon.324-328

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…r-met-hu G-CSF short term enhancement of WBCs mobilization on this work was as expected (in both studied species). Accordingly, peripheral WBCs increase in numbers within days of administration as reported in humans, pigs, horses, rats and mice [39–43]. The fact that guinea pigs WBCs, mainly granulocytes, peaked 2 days after administration with all doses levels used while in ram lambs all WBC types gradually increased in numbers right after r-met-hu G-CSF administration, indicates that r-met-hu/G-CSF doses were enough to activate and mobilize bone marrow hematopoietic stem cells in guinea pigs while in ovine species higher doses were required.…”

Section: Discussionmentioning

confidence: 98%

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Aponte¹,

Gutiérrez-Reinoso

Sanchez-Cepeda

et al. 2019

PLoS ONE

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The understanding of mammalian spermatogenesis niche factors active during sexual development may be leveraged to impact reproduction in farm animals. The aim of this study was to evaluate the effects of r-met-hu/G-CSF (filgrastim) on prepubertal sexual development of guinea pigs (Cavia porcellus) and ram lambs (Ovis aries). Individuals of both species were administered r-met-hu/G-CSF daily for 4 days. During and after administration protocols, testicular function and development were assessed through hematological responses, hormonal profiles (gonadotropins, testosterone and cortisol) testicular morphometry and germ cell kinetics. As expected, r-met-hu/G-CSF acutely mobilized white-lineage blood cells in both species. LH was increased by r-met-hu/G-CSF in guinea pigs (P<0.01) but T remained unchanged. In ram lambs gonadotropins and T increased in dose-response fashion (P<0.01) while cortisol values were stable and similar in treated and control animals (P>0.05). In guinea pigs there were no differences in testicular weights and volumes 2-mo after r-met-hu/G-CSF application (P>0.05). However, ram lambs showed a dose-response effect regarding testis weight (P<0.05). 66.66% of ram lambs had initial testes not yet in meiosis or starting the first spermatogenic wave. After 60-days only 25% of control animals were pubertal while all treated animals (1140-μg) had reached puberty. We propose an integrated hypothesis that G-CSF can stimulate spermatogenesis through two possible ways. 1) r-met-hu/G-CSF may go through the brain blood barrier and once there it can stimulate GnRH-neurons to release GnRH with the subsequent release of gonadotrophins. 2) a local testicular effect through stimulation of steroidogenesis that enhances spermiogenesis via testosterone production and a direct stimulation over spermatogonial stem cells self-renewal. In conclusion, this study shows that r-met-hu/G-CSF differentially affects prepubertal sexual development in hystricomorpha and ovine species, a relevant fact to consider when designing methods to hasten sexual developmental in mammalian species.

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Section: Discussionmentioning

confidence: 98%

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Aponte¹,

Gutiérrez-Reinoso

Sanchez-Cepeda

et al. 2019

PLoS ONE

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“…The clinical armamentarium widely employed for the prevention and management of CIN encompasses recombinant human G-CSF (rhG-CSF) and its polyethylene glycol-modified counterpart (PEG-rhG-CSF) [5] . The former, rhG-CSF, represents a short-acting G-CSF necessitating administration over multiple days per chemotherapy cycle.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Adverse Events Linked to PEG-rhG-CSF and rhG-CSF in Real-World Settings: Disproportionate Examination of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) Database

Qu,

Zuo,

Zhang

et al. 2024

Preprint

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Granulocyte-colony stimulating factor (G-CSF) is widely acknowledged for its efficacy in managing chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN), albeit accompanied by a spectrum of potential adverse effects. This study conducted a comprehensive analysis utilizing real-world data sourced from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database, spanning the years 2004 to 2023, to assess and compare adverse events (AEs) associated with recombinant human G-CSF (rhG-CSF) and its polyethylene glycol-modified form (PEG-rhG-CSF). The analysis revealed a significant increase in the incidence of AEs, with PEG-rhG-CSF implicated in 76,155 cases and rhG-CSF in 10,953 cases. A gender-based disparity was evident, with female patients experiencing a higher incidence of AEs compared to male patients. Specifically, the incidence rates for PEG-rhG-CSF and rhG-CSF in females were 54.2% and 46.1%, respectively, versus 27.1% and 34.7% in males. Bone pain emerged as the most prevalent AE, with PEG-rhG-CSF and rhG-CSF accounting for 2,473 and 581 cases, respectively. Reporting odds ratio (ROR) analysis indicated a higher incidence of bone pain with PEG-rhG-CSF compared to rhG-CSF, with an ROR of 1.17 (95% CI: 1.07-1.29). Furthermore, the study highlighted significant differences in the time to onset of AEs between the two treatments. The median time to onset of AEs was 3 days (IQR: 1-9; p<0.05) for PEG-rhG-CSF, in contrast to 9 days (IQR: 2-42) for rhG-CSF. Notably, the emergence of splenomegaly, capillary leak syndrome, interstitial lung disease, and lung infiltration exhibited delayed intervals, underscoring the imperative for meticulous patient follow-up, particularly given the potential for patient discharge prior to the manifestation of these delayed AEs. Further assessment of real-world data is warranted.

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Mathematical modeling of the neutrophil production process supported by administration of glycoprotein

Mika

Pełka

Tkacz

2021

Biocybernetics and Biomedical Engineering

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Filgrastim and Pegfilgrastim Use in Patients With Neutropeni

Cited by 4 publications

References 55 publications

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Comparative Analysis of Adverse Events Linked to PEG-rhG-CSF and rhG-CSF in Real-World Settings: Disproportionate Examination of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) Database

Mathematical modeling of the neutrophil production process supported by administration of glycoprotein

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