Filarial breast lump

Panda, Dwijesh Kumar; Mohapatra, Devi Prasad; Mohapatra, Madhusmita Mohanty

doi:10.1136/bcr-2017-221536

Cited by 2 publications

(3 citation statements)

References 3 publications

(1 reference statement)

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“…Ziehl-Neelsen staining, culture or PCR can be used for establishing the diagnosis 59 60. Other unusual pathogens that can cause granulomatous mastitis include Bartonella henselae 61 62, atypical mycobacteria,63–65 Actinomyces ,66 Brucella ,67 fungi68 69 and parasites 70–73. These unusual infections may be the initial presentation of HIV infection 74…”

Section: Differential Diagnosismentioning

confidence: 99%

Cystic neutrophilic granulomatous mastitis: an update

Turashvili

2020

J Clin Pathol

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Cystic neutrophilic granulomatous mastitis (CNGM) is a rare subtype of granulomatous mastitis with a highly distinct histological pattern often associated with Corynebacterium species. CNGM is characterised by suppurative lipogranulomas that are composed of central lipid vacuoles rimmed by neutrophils and an outer cuff of epithelioid histiocytes. Some of the lipid vacuoles may contain sparse, rod-shaped, gram-positive bacilli that can be easily missed or dismissed. The surrounding mixed inflammatory infiltrate contains Langhans-type giant cells, lymphocytes and neutrophils. CNGM occurs in reproductive age women with a history of pregnancy and typically presents as a palpable mass that can be painful. CNGM has many mimickers, most significantly breast carcinoma. In many cases, CNGM has significant pathological and clinical overlap with other forms of granulomatous mastitis. Given the association with Corynebacterium species, early diagnosis of CNGM is essential in offering patients the most appropriate treatment. Prolonged antibiotic therapy specifically directed to corynebacteria is required, sometimes even beyond resolution of clinical symptoms. This comprehensive review of the existing literature on CNGM describes clinical–pathological features, microbiological findings, challenges associated with the microscopic differential diagnosis, clinical implications of this diagnosis and emerging treatment options. Morphological criteria and suggested comments to convey the degree of diagnostic certainty are also proposed for standard pathology reporting.

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Section: Differential Diagnosismentioning

confidence: 99%

Cystic neutrophilic granulomatous mastitis: an update

Turashvili

2020

J Clin Pathol

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“…Patients with breast filariasis can present with a variety of clinical manifestations, ranging from asymptomatic to a breast lump which mimics inflammatory breast cancer [ 14 ]. A few case reports have shown that breast filariasis is mostly caused by Wuchereria bancrofti [ [4] , [5] , [6] , 14 ]. The most common site of breast filariasis is the upper outer quadrant of the breast, and the lesion seldom invades the ductal part [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Presentation of breast filariasis is rare and may be misdiagnosed as a breast tumor or cyst [ 3 ]. The majority of the reported cases have been from India, which is an endemic area of lymphatic filariasis [ [4] , [5] , [6] ]. Extralymphatic presentations of filariasis have also been caused by zoonotic filaria [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

Thongpiya

Sa-nguanraksa

Samarnthai

et al. 2021

Parasitology International

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Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the same time, a small nodule was found in her right breast, via imaging study, without any abnormal symptoms. A core needle biopsy of the right breast nodule revealed a filarial-like nematode compatible with the adult stage of Brugia sp. A molecular identification of the nematode partial mt 12rRNA gene and ITS1 suggested the causative species as closely related to Brugia pahangi , a zoonotic lymphatic filaria of animals such as cats and dogs. The sequence of the partial mt 12rRNA and ITS1 gene in this patient was 94% and 99% identical to the previously reported sequence of mt 12rRNA and ITS1 genes of B. pahangi. The sequence of ITS1 gene is 99% similar to B. pahangi microfilaria from infected dogs in Bangkok, which was highly suspected of having a zoonotic origin. As far as we know, this is the first case report of B. pahangi filariasis presented with a breast mass concomitantly found in a patient with invasive ductal carcinoma. This raised serious concern regarding the zoonotic transmission of filariasis from natural animal reservoirs.

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Filarial breast lump

Cited by 2 publications

References 3 publications

Cystic neutrophilic granulomatous mastitis: an update

Cystic neutrophilic granulomatous mastitis: an update

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

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