Filamin protects myofibrils from contractile damage through changes in its mechanosensory region
Lucas AB Fisher,
Belén Carriquí-Madroñal,
Tiara Mulder
et al.
Abstract:Filamins are mechanosensitive actin crosslinking proteins that organize the actin cytoskeleton in a variety of shapes and tissues. In muscles, filamin crosslinks actin filaments from opposing sarcomeres, the smallest contractile units of muscles. This happens at the Z-disc, the actin-organizing center of sarcomeres. In flies and vertebrates, filamin mutations lead to fragile muscles that appear ruptured, suggesting filamin helps counteract muscle rupturing during muscle contractions either by providing elastic… Show more
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