Filamentous tropical marine cyanobacteria: a rich source of natural products for anticancer drug discovery

Tan, Lik Tong

doi:10.1007/s10811-010-9506-x

Cited by 120 publications

(106 citation statements)

References 112 publications

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“…Marine cyanobacteria are vital producers of diverse chemical entities with significant bioactivities [7][8][9][10]. The genus Moorea (formerly Lygnbya) [11] has been proven to be a rich source for novel bioactive compounds of different classes [11,12].…”

Section: Introductionmentioning

confidence: 99%

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

et al. 2016

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Abstract:In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2 1 -deoxyuridine (2) and 3-phenylethyl-2 1 -deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds 1-5 showed variable cytotoxic activity against three cancer cell lines.

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Section: Introductionmentioning

confidence: 99%

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

et al. 2016

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“…n recent years, tropical and subtropical, benthic marine cyanobacteria have attracted much attention due to their extraordinary capacities to produce structurally diverse and highly bioactive secondary metabolites (1)(2)(3)(4). These bioactive molecules deter grazers, are often potent toxins, and can underlie cyanobacterial harmful algal blooms (CyanoHABs) (5,6).…”

mentioning

confidence: 99%

“…Despite their toxicity, many cyanobacterial secondary metabolites also have potential for a broad spectrum of pharmaceutical applications, such as anticancer, anti-inflammatory, antibacterial, and anti-infective applications (1,2,4,9). In addition, many of these cyanobacterial secondary metabolites also have other potential commercial applications, such as insecticides, algaecides, and herbicides (10).…”

mentioning

confidence: 99%

Phylogenetic Inferences Reveal a Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria

Engene

Gunasekera

Gerwick

et al. 2013

Appl Environ Microbiol

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bBenthic marine cyanobacteria are known for their prolific biosynthetic capacities to produce structurally diverse secondary metabolites with biomedical application and their ability to form cyanobacterial harmful algal blooms. In an effort to provide taxonomic clarity to better guide future natural product drug discovery investigations and harmful algal bloom monitoring, this study investigated the taxonomy of tropical and subtropical natural product-producing marine cyanobacteria on the basis of their evolutionary relatedness. Our phylogenetic inferences of marine cyanobacterial strains responsible for over 100 bioactive secondary metabolites revealed an uneven taxonomic distribution, with a few groups being responsible for the vast majority of these molecules. Our data also suggest a high degree of novel biodiversity among natural product-producing strains that was previously overlooked by traditional morphology-based taxonomic approaches. This unrecognized biodiversity is primarily due to a lack of proper classification systems since the taxonomy of tropical and subtropical, benthic marine cyanobacteria has only recently been analyzed by phylogenetic methods. This evolutionary study provides a framework for a more robust classification system to better understand the taxonomy of tropical and subtropical marine cyanobacteria and the distribution of natural products in marine cyanobacteria.

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“…The cosmopolitan freshwater cyanobacterium Heteroleiblenia kuetzingii produce intracellular and extracellular compounds, toxic to several mouse and fish cell lines [23]. Dolastatins (pseudopeptides) are an interesting group of biologically active metabolites, isolated from marine cyanoprokaryotes, mainly from the genera Lyngbya, Oscillatoria and Symploca [24]. Dolastatins are the basis for the development of synthetic drug analogues having better pharmacological and pharmacokinetic properties in the treatment of different cancer types [25].…”

Section: ) From Nostoc Flagelliformementioning

confidence: 99%

Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance

Gacheva

Gigova

2014

Open Life Sciences

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The escalating levels of antibiotic resistance among pathogenic bacteria and the side effects of chemotherapeutic drugs in use forced the efforts of scientists to search for natural antimicrobial and anticancer substances with novel structures and unique mechanism of action. Focusing on bioproducts, recent trends in drug research have shown that microalgae (including the cyanobacteria) are promising organisms to furnish novel and safer biologically active compounds. Many microalgal metabolites have been found to possess potent antibacterial, antifungal, antiviral, anticancer and antiinflammatory activities, as well as antioxidant, enzyme inhibiting and immunostimulating properties. In this paper, the studies on the biological activity of microalgae associated with potential medical and pharmaceutical applications are briefly presented. Attention is focused on the impact of cultivation temperature, irradiance and growth stage on the biomass accumulation, activity and pathways of cell metabolism and the possibilities of using these variable factors to increase the diversity and quantity of biologically active substances synthesized by microalgae.

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Filamentous tropical marine cyanobacteria: a rich source of natural products for anticancer drug discovery

Abstract: A plethora of structurally novel bioactive secondary metabolites have been reported from the prokaryotic filamentous marine cyanobacteria in the past few decades.

Cited by 120 publications

References 112 publications

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

Phylogenetic Inferences Reveal a Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria

Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance

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