Filaggrin polymorphism P478S, IgE level, and atopic phenotypes

Wang, I. J.; Lin, Ting-Yun; Kuo, Chi‐Tai; Lin, Sheue-Rong; Lee, Yungling Leo; Chen, Pau‐Chung

doi:10.1111/j.1365-2133.2011.10212.x

Cited by 36 publications

(37 citation statements)

References 34 publications

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“…Similarly, Wang et al . showed that the association between FLG variants and eczema was limited to a subset of children with IgE levels ≥ 100 kU/L . Hence, we suggest considering the combined effect of both risk factors rather than taking the cause–effect approach could lead to a better risk assessment.…”

Section: Discussionmentioning

confidence: 91%

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort

Ziyab

Karmaus

Zhang

et al. 2014

Clin Experimental Allergy

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Background Allergic sensitization and filaggrin gene (FLG) variants are important risk factors for allergic disorders; however, knowledge on their individual and interactive effects on the coexistence of eczema, asthma, and rhinitis is lacking. Objective This study aimed at investigating the single and combined effects of allergic sensitization and FLG variants on the development of single and multiple allergic disorders. Methods The Isle of Wight Birth Cohort (n = 1,456) has been examined at 1, 2, 4, 10, and 18 years of age. Repeated measurements of eczema, asthma, rhinitis, and skin prick tests were available for all follow-ups. FLG variants were genotyped in 1,150 participants. Associations of allergic sensitization and FLG variants with single and multiple allergic disorders were tested in log-binomial regression analysis. Results The prevalence of eczema-, asthma-, and rhinitis-only ranged from 5.6% to 8.5%, 4.9% to 10.2%, and 2.5% to 20.4%, respectively, during the first 18 years of life. The coexistence of allergic disorders is common, with approximately 2% of the population reporting the comorbidity of “eczema, asthma, and rhinitis” during the study period. In repeated measurement analyses, allergic sensitization and FLG variants, when analyzed separately, were associated with having single and multiple allergic disorders. Of particular significance, their combined effect increased the risk of “eczema and asthma” (RR = 13.67, 95% CI: 7.35 – 25.42), “asthma and rhinitis” (RR = 7.46, 95% CI: 5.07 – 10.98), and “eczema, asthma, and rhinitis” (RR = 23.44, 95% CI: 12.27 – 44.78). Conclusions and Clinical Relevance The coexistence of allergic disorders is frequent and allergic sensitization and FLG variants jointly increased risk of allergic comorbidities, which may represent more severe and complex clinical phenotypes. The interactive effect and the elevated proportion of allergic comorbidities associated with allergic sensitization and FLG variants emphasize their joint importance in the pathogenesis of allergic disorders.

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Section: Discussionmentioning

confidence: 91%

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort

Ziyab

Karmaus

Zhang

et al. 2014

Clin Experimental Allergy

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“…Sequences specifically present or absent in the A or Aʹ variant might affect filaggrin processing and be a hidden factor for AD development – a hypothesis to be tested in other epidemiological or experimental settings. In this sense, there was an interesting report from Taiwan showing that the FLG polymorphism P478S (rs11584340) might confer susceptibility to AD – the GG genotype increased the risk of AD. P478S polymorphism originates from the G>A SNP located 1432 bp from the open reading frame (Fig.…”

Section: Copy‐number Variation and Associated Genotypes Of Flg In Kormentioning

confidence: 99%

Copy-number variation of the filaggrin gene in Korean patients with atopic dermatitis: what really matters, ‘number’ or ‘variation’?

Seok

Park

et al. 2016

Br J Dermatol

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“…These mutations were present in 31.4 % of 261 patients with AD but were not associated with asthma [ 35 ]. Also Li et al [ 32 ] and Wang et al [ 34 ] studied FLG mutations in the Chinese population but, in contrast to the study by Zhang et al, found a positive association with asthma. Particularly the study by Wang et al found that the P478S GG genotype signifi cantly increased the risk of developing asthma in patients with AD, OR = 4.68 (1.37-16.03).…”

Section: Populations Of Non-european Descentmentioning

confidence: 94%

Asthma

Thomsen

2014

Filaggrin

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Filaggrin polymorphism P478S, IgE level, and atopic phenotypes

Abstract: Our results suggest that the FLG P478S polymorphism may confer susceptibility to the development of AD among Chinese individuals and may be modified by IgE levels.

Cited by 36 publications

References 34 publications

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort

Copy-number variation of the filaggrin gene in Korean patients with atopic dermatitis: what really matters, ‘number’ or ‘variation’?

Asthma

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