Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis

Molin, Sonja; Vollmer, Sigrid; Weiss, Emma; Ruzicka, Thomas; Prinz, J. C.

doi:10.1111/j.1365-2133.2009.09245.x

Cited by 107 publications

(69 citation statements)

References 34 publications

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“…Previous studies have implicated skin barrier dysfunction resulting from genetic modifications in the pathogenesis of HE [7][8][9]. In the present study, we measured the skin barrier function and the expression of caspase-14 in CHE patients.…”

Section: Discussionmentioning

confidence: 94%

“…The stratum corneum maintains an optimal level of hydration by relying on several important factors including intercellular lamellar lipids, diffusion path length, and natural moisturizing factors (NMFs), and the disturbance of any processes affecting these factors will result in abnormal skin hydration [15]. Intriguingly, filaggrin gene mutations, which have been demonstrated to be able to confer susceptibility to CHE [8], result in reduced levels of NMFs in the stratum corneum [16], suggesting that disturbance of skin hydration may play a role in the pathogenesis of CHE.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic modifications in cornified envelope genes have been implicated in the development of HE [7,8]. Caspase-14 may be closely associated with the altered skin barrier function in epidermal disorders [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies have demonstrated that skin barrier dysfunction resulting from genetic modifications in cornified envelope genes may contribute to the development of HE [7,8], of which the gene encoding filaggrin, an important component of the cornified envelope, is the most extensively studied [8,9]. Caspase-14, a protease that is activated during keratinocyte cornification [10], is required for functional filaggrin degradation [11].…”

Section: Introductionmentioning

confidence: 99%

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Impaired Skin Barrier Function and Downregulated Expression of Caspase-14 in Moderate to Severe Chronic Hand Eczema

et al. 2018

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Aim: To investigate whether the skin barrier function is impaired with regard to the pH value, water content, transepidermal water loss (TEWL), and the integrity of the stratum corneum, and whether the expression of caspase-14 is altered in moderate to severe chronic hand eczema (CHE). Methods: Thirty patients with moderate to severe CHE treated at our institute and 30 healthy volunteers were included in this study. The pH value, water content, TEWL, and the integrity of the stratum corneum were measured in all subjects. Results: Significantly increased pH value, decreased water content, elevated TEWL, and impaired integrity of the stratum corneum were observed in the lesional skin of CHE patients compared with the nonlesional skin of CHE patients and the normal skin of healthy volunteers. The expression of caspase-14 decreased in the lesional and nonlesional skin of CHE patients compared with the normal skin of healthy volunteers, especially prominent in the nonlesional skin. The mean optical density (OD) value of immunohistochemical staining for caspase-14 was significantly lower in the nonlesional skin than in the lesional skin and normal skin (p < 0.01 for both). Although the mean OD value was lower in the lesional skin than in the normal skin, the difference was not statistically significant (p > 0.05). Conclusion: Skin barrier dysfunction indeed occurs in CHE patients, which may be related to mechanisms associated with a downregulated expression of caspase-14.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impaired Skin Barrier Function and Downregulated Expression of Caspase-14 in Moderate to Severe Chronic Hand Eczema

et al. 2018

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“…It is likely that a significant subset of respondents had atopic hand dermatitis. However, there are other phenotypes of hand dermatitis, such as chronic fissured, allergic, and irritant hand dermatitis, which occur in absence of atopic phenotype and have distinct FLG mutations [98,99].…”

Section: Obesity and Hand Dermatitismentioning

confidence: 99%

Atopic Dermatitis: Update on Pathogenesis and Comorbidities

Silverberg

2012

Curr Derm Rep

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Atopic dermatitis (AD) is a significant cause of morbidity and healthcare costs in the United States and worldwide. The prevalence of AD in childhood is rising in the United States and other developed countries for reasons that are not well understood. Similarly, the prevalences of obesity and diabetes are on the rise, which might be contributing toward increased AD. This article reviews the association between AD and other atopic disorders with obesity and diabetes. Furthermore, recently recognized AD comorbidities, including fatty liver disease and erectile dysfunction, are reviewed. Potential mechanisms for the association between AD and metabolic disorders are discussed.

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Eczematous Disorders

Ingram

2016

Rook's Textbook of Dermatology, Ninth Edition

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Eczema, also known as dermatitis, is a clinical and histopathological pattern of skin inflammation, which presents as pruritus, skin dryness and erythema. This chapter covers the non‐atopic eczema subtypes, which can be classified based on aetiology and skin site. The main subtypes are: nummular dermatitis, asteatotic eczema, hand eczema, venous eczema of the lower legs, eyelid eczema, juvenile plantar dermatosis and miscellaneous eczematous dermatoses. Eczema may result in skin lichenification and severe eczema is the commonest cause of erythroderma. Quality of life for patients and their families may be considerably reduced and occupational issues may add to the financial consequences. Management of non‐atopic eczema involves the avoidance of any external causes, where relevant, and treatment modalities that are similar to those for atopic eczema, in the context that relatively few clinical trials have been performed for non‐atopic eczema.

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Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis

Abstract: Heterozygosity for nonfunctional mutations in the FLG gene may contribute to the manifestation and maintenance of a particular CHE subtype that is characterized by the combination of allergic and irritant contact dermatitis.

Cited by 107 publications

References 34 publications

Impaired Skin Barrier Function and Downregulated Expression of Caspase-14 in Moderate to Severe Chronic Hand Eczema

Impaired Skin Barrier Function and Downregulated Expression of Caspase-14 in Moderate to Severe Chronic Hand Eczema

Atopic Dermatitis: Update on Pathogenesis and Comorbidities

Eczematous Disorders

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