Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis

Cai, Sophie; Chen, H.; Koh, Woon‐Puay; Common, John E.A.; Bever, Hugo P. Van; McLean, W.H. Irwin; Lane, E. Birgitte; Giam, Yoke Chin; Tang, Mark B Y

doi:10.1111/j.1365-2133.2011.10541.x

Cited by 65 publications

(47 citation statements)

References 14 publications

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“…However, these markers tend to have a later onset (>3 y old) (72). Recent studies have associated FLG with AD severity, persistence, skin infections, and food allergy (8,73). Therefore, FLG may be a potential prognostic marker for clinical use.…”

Section: Clinical Implications and Challengesmentioning

confidence: 99%

New insights in the pathogenesis of atopic dermatitis

Ong

2013

Pediatr Res

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Section: Clinical Implications and Challengesmentioning

confidence: 99%

New insights in the pathogenesis of atopic dermatitis

Ong

2013

Pediatr Res

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“…It makes the skin more sensitive to S. aureus infection because of its alkalization [10,11]. The literature data proved that more than 90% of patients with AD suffer from infection with S. aureus [12,13]. In many cases, including the one described above, there is a problem with successful therapy because of the strain's resistance to various antibiotics [14].…”

Section: Discussionmentioning

confidence: 99%

Possible immunological consequences of filaggrin gene mutation. A case study of a 3-year-old allergic girl

Ogrodowczyk¹,

Wróblewska²,

Markiewicz³

et al. 2013

cejoi

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“…Patients without the FLG-null mutations were controls. The risk was much greater in those with mild or moderate disease and was seen in both users and nonusers of oral steroids [ 17 ].…”

Section: Skin Cancer and Filaggrinmentioning

confidence: 98%

Atopic Dermatitis and Skin Cancer

2014

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Filaggrin gene ( FLG ) mutation carriage increases the risk of atopic dermatitis (AD), contact allergy, asthma, hay fever, and peanut allergy. These genetic variants also infl uence the severity of asthma and alopecia areata and susceptibility to herpetic infection [ 1 ]. Squamous cell carcinoma (SSC) in the skin is perhaps the most rapidly increasing malignancy arising through mutations in epidermal cells in sun-exposed areas. UVB radiation damages the DNA and its repair system and causes mutations in tumor-suppressing genes. The risk of metastasis increases if the mutated cells penetrate the dermis. Other risk factors for SCC include chronic sun exposure to UVB and UVA, a suppressed immune system due to treatment effects, exposure to cyclic aromatic hydrocarbons in tar, or long-standing infl ammation. Basal cell carcinoma (BCC) arises from basal keratinocytes in epidermis. In this kind of tumor, UVB is also important for the induction of damaging the DNA and its repair system and also causing mutations in tumor-suppressing genes. BCC grows by direct extension and almost never metastasizes. Malignant melanoma (MM) is a malignancy of melanocytes located mostly in the skin but also in the eyes, ears, central nervous system, and gastrointestinal (GI) tract. Malignant melanoma accounts for approximately 4 % of skin cancers but is responsible for more than 74 % skin cancer deaths [ 2 ]. The melanocyte transformation is poorly understood. It involves a series of steps, several unknown, with progressive genetic mutation that alters cell proliferation, differentiation, and death, and has an impact from

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Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis

Abstract: This study highlights a novel association between FLG-null mutations and an increased susceptibility to recurrent bacterial skin infection among patients with AD.

Cited by 65 publications

References 14 publications

New insights in the pathogenesis of atopic dermatitis

New insights in the pathogenesis of atopic dermatitis

Possible immunological consequences of filaggrin gene mutation. A case study of a 3-year-old allergic girl

Atopic Dermatitis and Skin Cancer

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