Figure SF2 from Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme

Abstract

<p>Differential network topology contrasting the short-term with the long-term survival network. A) Differential network modules significantly enriched for overrepresentation of Gene Ontology terms. Modules are shown for both discovery datasets (D1 and D2). Two modules were significant in both dataset (indicated with M1 and M2). The color in the heatmap indicates the enrichment of genes in the module as observed/expected value (Obs/Exp), with purple representing enriched modules in discovery dataset 1 and green enriched modules in discovery dataset 2. B) "Beeswarm" plot visualizing the distribution of average log differential modularity scores from ALPACA, for transcription factors (TF) and genes (Gene). Higher scores mean higher differential modularity. TFs and genes with significant differential modularity between the two survival groups are labeled.</p>