Abstract:<p>Schematic representation of quadruplex structure and role of the NHEIII1 region in transcriptional regulation of MYC. NHEIII1 is located upstream of MYC promoter 1 and consists of the G-rich and C-rich strands which form G-quadruplex and i-motif, respectively. The formation of G-quadruplex in the MYC NHEIII1 region is considered to be a transcriptional silencer. Signals for initiation of cancer, recruit SP1 to bind to NHEIII1 region through denaturation of G-quadruplex and i-motif which results in FUS… Show more
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