Figure S1-S8 from Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in <i>BRCA1</i> Mutation Carriers

Abstract

&lt;p&gt;Figure S1. Known cell type specific makers used to define clusters; Figure S2. The aberrant proportions of epithelial cells in normal breast tissues from BRCA1 mutation carriers validated by immunohistochemistry staining and bulk RNA-seq data; Figure S3. Impaired differentiation processes of luminal and basal/myoepithelial lineages in normal breast tissue from BRCA1 mutation carriers; Figure S4. Identification and characterization of the tumor cells in BRCA1 mutation carriers; Figure S5. Upregulated and downregulated pathways in tumor cells compared with their putative cells of origin in each BRCA1 mutation carrier; Figure S6. Comparison of the expression levels of KRT14/17 in luminal progenitor cells in normal breast tissue between BRCA1 mutation carriers and non-carriers; Figure S7. Comparison of the basal/mesenchymal features of luminal progenitor cells in normal breast tissue between BRCA1 mutation carriers and non-carriers; Figure S8. Validation of the heterogeneity of basal/mesenchymal features in normal mammary tissue from BRCA1 mutation carriers by bulk RNA-seq&lt;/p&gt;