FIGO stage IV epithelial ovarian, fallopian tube and peritoneal cancer revisited

Ataseven, Beyhan; Chiva, Luis; Harter, Philipp; González-Martín, Antonio; Bois, Andreas du

doi:10.1016/j.ygyno.2016.06.013

Cited by 80 publications

(74 citation statements)

References 90 publications

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“…These extra-abdominal metastases are found to be present in 12%–33% of the patients at initial diagnosis 8. Overall, median survival for patients with stage IV disease ranges from 15 to 29 months, with an estimated 5-year survival of approximately 20% 8. In presence of CPLN, the patient discussed above, suffered from stage IVB ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

“…This includes pleural effusion with positive cytology (stage IVA), lung parenchymal metastases and metastases to extra-abdominal organs including inguinal lymph nodes and lymph nodes outside of the abdominal cavity (stage IVB) 7. These extra-abdominal metastases are found to be present in 12%–33% of the patients at initial diagnosis 8. Overall, median survival for patients with stage IV disease ranges from 15 to 29 months, with an estimated 5-year survival of approximately 20% 8.…”

Section: Discussionmentioning

confidence: 99%

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Relevance of enlarged cardiophrenic lymph nodes in determining prognosis of patients with advanced ovarian cancer

et al. 2018

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Ovarian cancer often presents at an advanced stage with widespread peritoneal and/or extra-abdominal metastases. Complete cytoreduction is the mainstay of treatment for disease confined to peritoneum. But in patients with distant metastases, the role and rationale is less obvious. One of the the most common sites of extra-abdominal disease is the cardiophrenic lymph node (CPLN). In this paper, we described the management of a patient with International Federation of Gynecology and Obstetrics (FIGO) stage IVB epithelial ovarian carcinoma and widespread peritoneal and extra-abdominal metastases to the CPLN, who underwent complete cytoreduction including excision of enlarged CPLN, following neoadjuvant chemotherapy. We examined the literature to determine the prognostic value of enlarged CPLN and their relevance in managing patients with advanced ovarian cancer and found it as an adverse prognostic factor. Transdiaphragmatic excision of CPLN is feasible without major complications. But as its correlation with overall or progression-free survival is not yet evident, large-scale prospective studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relevance of enlarged cardiophrenic lymph nodes in determining prognosis of patients with advanced ovarian cancer

et al. 2018

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“…In China, the mortality rate of ovarian cancer is the second highest among all gynecological malignancies 2. Due to its inconspicuous symptoms and signs, most patients with ovarian cancer are diagnosed at advanced stages when pelvic and peritoneal dissemination has already occurred,4, 5 suggesting a highly invasive and metastatic nature of ovarian cancer and a lack of treatment methods for the patients at advanced stages. Thus, it is crucial to understand the molecular processes that underlie the progression of ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

The non‐coding RNA OTUB1‐isoform2 promotes ovarian tumour progression and predicts poor prognosis

Wang

Ning

Wei

et al. 2018

J Cellular Molecular Medi

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Ovarian cancer is the leading malignancy of the female reproductive system and is associated with inconspicuous early invasion and metastasis. We have previously reported that the oncogene OTUB1 plays a crucial role in ovarian cancer progression, but the role of its isoform, the non‐coding RNA OTUB1‐isoform2, in ovarian cancer is still elusive. Here, we reported that OTUB1‐isoform2 expression in ovarian cancer tissues was significantly higher than that in the paired paratumorous tissues (P < .01). The patients with high expression of OTUB1‐isoform2 had larger tumours than those with low expression (P < .05). The high expression of OTUB1‐isoform2 was correlated with the involvement of bilateral ovaries (P < .05), lymph node metastasis (P < .05), vascular invasion (P < .05), greater omentum involvement (P < .01), fallopian tube involvement (P < .05), advanced FIGO stages (P < .01) and recurrence (P < .01). Moreover, OTUB1‐isoform2 served as an independent negative prognostic predictor for disease‐free survival (DFS) and disease‐specific survival (DSS). Overexpression of OTUB1‐isoform2 in the ovarian cancer cells stimulated cell proliferation, migration and invasion both in vitro and in vivo. In summary, our study suggested that OTUB1‐isoform2 is a novel prognostic biomarker with independent oncogenic functions for ovarian cancer.

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confidence: 99%

“…1 Approximately 95% of these cancers are epithelial in origin. 1 Presentation is characteristically late, with up to 70% of patients presenting with at least International Federation of Gynecology and Obstetrics stage III disease. 1,2 The European Society of Urogenital Radiology (ESUR) recommended coverage from the base of the lungs to the inguinal region with multidetector computed tomography (MDCT) for preoperative staging.…”

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confidence: 99%

Incidental Thoracic Findings on Routine Computed Tomography in Epithelial Ovarian Cancer

OʼLeary

Treacy

Geoghegan

et al. 2018

International Journal of Gynecological Cancer

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FIGO stage IV epithelial ovarian, fallopian tube and peritoneal cancer revisited

Cited by 80 publications

References 90 publications

Relevance of enlarged cardiophrenic lymph nodes in determining prognosis of patients with advanced ovarian cancer

Relevance of enlarged cardiophrenic lymph nodes in determining prognosis of patients with advanced ovarian cancer

The non‐coding RNA OTUB1‐isoform2 promotes ovarian tumour progression and predicts poor prognosis

Incidental Thoracic Findings on Routine Computed Tomography in Epithelial Ovarian Cancer

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