Fighting the flu: a brief review on anti-influenza agents

Chakraborty, Sambuddha; Chauhan, Ashwini

doi:10.1080/02648725.2023.2191081

Cited by 6 publications

(2 citation statements)

References 266 publications

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“…Moreover, alkaloids as a main source of phytochemicals can be used for the development and discovery of new natural anti-influenza drugs. Alkaloids with their inhibitory effects on the replication of influenza viruses and inhibition of inflammation in the lungs can be considered resources for the production of herbal drugs against influenza viruses (18,19). Moradi et al have indicated that the anti-influenza A virus activity of Peganum harmala L. extract might be attributed to its alkaloid components (20).…”

Section: Introductionmentioning

confidence: 99%

Berberine as a new neuraminidase inhibitor drug: A systematic review

Asadi-Samani,

Altememy,

Saffari-Chaleshtor

et al. 2024

J Herbmed Pharmacol

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Influenza neuraminidase (NA) plays a main role in the viral replication of the influenza virus. It has been considered one of the targets for anti-influenza drugs. Anti-influenza drugs such as zanamivir, oseltamivir, and peramivir can fight the virus via the inhibition of NA. However, due to adverse reactions, the resistance of the viral strains and sudden changes in NA inhibitors, the identification of novel inhibitors is needed. Nature products such as berberine have been reported against influenza. In this systematic review, we have focused on the anti-influenza effects of berberine and its main role in the inhibition of NA of the virus. For this aim, "Berberine" was searched with "Influenza" or "flu" or "common cold" or "neuraminidase" in Web of Science, PubMed, Scopus, and Google Scholar databases from 1990 to April 2023. Studies have demonstrated that berberine and its derivatives have a wide range of biological effects such as antiviral effects against viruses like herpes simplex virus, human cytomegalovirus, and influenza A virus. The present study indicates that berberine and some of its derivatives are able to inhibit the influenza virus through NA blockade. Berberine is able to superimpose into the allosteric binding site and shows reversible non-competitive behavior in the ligand-receptor interaction for the inhibition of NA.

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Section: Introductionmentioning

confidence: 99%

Berberine as a new neuraminidase inhibitor drug: A systematic review

Asadi-Samani,

Altememy,

Saffari-Chaleshtor

et al. 2024

J Herbmed Pharmacol

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“…For the treatment and prophylaxis of influenza, the WHO recommends the use of ethiotropic drugs that have a direct effect on the reproduction of the virus. Anti-influenza drugs currently used in clinical practice are aimed at inhibiting the activity of influenza virus proteins: neuraminidase (oseltamivir, zanamivir, laninamivir, peramivir), M2-proton channel (amantadine and rimantadine), PA endonuclease (baloxavir marboxil), RNAdependent RNA polymerase complex (favipiravir, ribavirin) [3][4][5][6][7][8]. Modern methods for specific prophylaxis and treatment of influenza are not always effective, because of rapid mutations of the virus and the emergence of drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies

Mochulskaya,

Kotovskaya,

Butorin

et al. 2023

Chemistry

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A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition reaction of N(1)-ethyl-1,2,4-triazinium tetrafluoroborates with dimethyl acetylenedicarboxylate. The antiviral activity of the synthesized compounds against influenza virus strain A/Puerto Rico/8/34 (H1N1) was studied in experiments on Madin-Darby canine kidney (MDCK) cell culture. Among the pyrrolo[2,1-f][1,2,4]triazine derivatives, compounds with low toxicity and high antiviral activity were identified. Dimethyl 4-(4-methoxyphenyl)-7-methyl-2-p-tolylpyrrolo[2,1-f][1,2,4]triazine-5,6-dicarboxylate was found to demonstrate the best antiviral activity (IC50 4 µg/mL and selectivity index 188). Based on the results of in vitro tests and molecular docking studies performed, a plausible mechanism of action for these compounds was suggested to involve inhibition of neuraminidase.

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Mixed Consortium of Salt-Tolerant Phosphate Solubilizing Bacteria Improves Maize (Zea mays) Plant Growth and Soil Health Under Saline Conditions

Chauhan

Upadhyay

2023

Mol Biotechnol

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Fighting the flu: a brief review on anti-influenza agents

Cited by 6 publications

References 266 publications

Berberine as a new neuraminidase inhibitor drug: A systematic review

Berberine as a new neuraminidase inhibitor drug: A systematic review

Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies

Mixed Consortium of Salt-Tolerant Phosphate Solubilizing Bacteria Improves Maize (Zea mays) Plant Growth and Soil Health Under Saline Conditions

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