Fighting Fire with Fire in Cancer

Berger, Thorsten; Saunders, Mary; Mak, Tak W.

doi:10.1007/978-4-431-55651-0_3

Cited by 2 publications

(3 citation statements)

References 57 publications

(90 reference statements)

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“…Consequently, cell proliferation is decreased, and lipid metabolism is impaired. Targeting these miRNAs has been proposed as a therapeutic strategy to combat malignant cancers with high CPT1C expression [21,23,30,37].…”

Section: Cpt1c Involvement In Migration Invasion and Cancer Cell Sene...mentioning

confidence: 99%

“…In xenograft mouse models, CPT1C depletion has been shown to reduce tumor growth and development, and, in several types of human tumors, low CPT1C expression is associated with increased overall survival. Because CPT1C is expressed only in the brain, while CPT1A and CPT1B are widely expressed in peripheral tissues, a promising anticancer strategy-as suggested by the group of Tak W. Mak [23,37]-is the development of small drugs or sh-RNA-carrying nanomedicines that specifically target CPT1C but are unable to penetrate the blood-brain-barrier [23,37]. Since CPT1C shows high homology with canonical isoforms, it is essential to understand small conformational variations between isoforms that may be druggable.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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To be or not to be a fat burner, that is the question for cpt1c in cancer cells

et al. 2023

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There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal protein carnitine palmitoyltransferase 1 C (CPT1C). Several studies report that CPT1C is involved in cancer cell adaptation to nutrient depletion and hypoxia. However, the molecular role played by CPT1C in cancer cells is controversial. Most published studies assume that, like canonical CPT1 isoforms, CPT1C is a mediator of fatty acid transport to mitochondria for beta-oxidation, despite the fact that CPT1C has inefficient catalytic activity and is located in the endoplasmic reticulum. In this review, we collate existing evidence on CPT1C in neurons, showing that CPT1C is a sensor of nutrients that interacts with and regulates other proteins involved in lipid metabolism and transport, lysosome motility, and the secretory pathway. We argue, therefore, that CPT1C expression in cancer cells is not a direct regulator of fat burn, but rather is a regulator of lipid metabolic reprograming and cell adaptation to environmental stressors. We also review the clinical relevance of CPT1C as a prognostic indicator and its contribution to tumor growth, cancer invasiveness, and cell senescence. This new and integrated vision of CPT1C function can help better understand the metabolic plasticity of cancer cells and improve the design of therapeutic strategies.

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Section: Cpt1c Involvement In Migration Invasion and Cancer Cell Sene...mentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

To be or not to be a fat burner, that is the question for cpt1c in cancer cells

et al. 2023

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“…Cancer will not be recovered until it is understood and knowing the unique alterations that identify normal cells from tumor cells (Berger et al, 2015). The optimum ideal strategy has not yet been announced.…”

Section: Introductionmentioning

confidence: 99%

Can malaria protein fight cancer?

Mannaa

2018

Com. Sci.

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Cancer risk depends on a combination of our genes, environment and other aspects of our lives, many of which we can control. Surgery, radiation and chemotherapy are often effective at treating people with a solid tumor, but once the cancer has spread and formed tiny tumors at distant sites, chances for a successful recovery are dismal.Recently, it was discovered that the malaria parasite, Plasmodium falciparum produce and present a malarial protein called VAR2CSA, which bind a type of sugar molecule exclusively found in the placenta. It was found that the exact same sugar molecule structure is also found in most cancer cells. Both molecules are a type of chondroitin sulfate. The VAR2CSA only adhere in the placenta and do not bind to chondroitin sulfate expressed elsewhere in the body. In tumors, placental-like chondroitin sulfate chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4. The recombinant VAR2CSA (rVAR2) protein localizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis.

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Fighting Fire with Fire in Cancer

Cited by 2 publications

References 57 publications

To be or not to be a fat burner, that is the question for cpt1c in cancer cells

To be or not to be a fat burner, that is the question for cpt1c in cancer cells

Can malaria protein fight cancer?

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