Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Schoberer, Mark; Lohr, Anne; Schumacher, Matthias; Jellema, Reint K.; Collins, Jennifer J. P.; Kramer, Boris W.; Schmitz‐Rode, Thomas; Steinseifer, Ulrich; Orlikowsky, Thorsten

doi:10.1111/j.1525-1594.2011.01404.x

Cited by 26 publications

(33 citation statements)

References 18 publications

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“…Here we demonstrate that extreme premature fetal lambs can be consistently supported in an extracorporeal device for up to 4 weeks without apparent physiologic derangement or organ failure. These results are superior to all previous attempts at extracorporeal support of the extreme premature fetus in both duration and physiologic well-being1617.…”

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confidence: 66%

An extra-uterine system to physiologically support the extreme premature lamb

et al. 2017

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In the developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to a combination of organ immaturity and iatrogenic injury. Until now, efforts to extend gestation using extracorporeal systems have achieved limited success. Here we report the development of a system that incorporates a pumpless oxygenator circuit connected to the fetus of a lamb via an umbilical cord interface that is maintained within a closed ‘amniotic fluid' circuit that closely reproduces the environment of the womb. We show that fetal lambs that are developmentally equivalent to the extreme premature human infant can be physiologically supported in this extra-uterine device for up to 4 weeks. Lambs on support maintain stable haemodynamics, have normal blood gas and oxygenation parameters and maintain patency of the fetal circulation. With appropriate nutritional support, lambs on the system demonstrate normal somatic growth, lung maturation and brain growth and myelination.

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confidence: 66%

An extra-uterine system to physiologically support the extreme premature lamb

et al. 2017

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“…Following the development and implementation of the heart–lung machine, it was soon recognized that this concept could be similarly applied to the treatment of severe respiratory failure of the premature infant . In 1958, Westin et al prolonged the life of previable human fetuses by cannulating the umbilical vessels and circulating the fetal blood through a rotating oxygenator .…”

Section: Early Milestonesmentioning

confidence: 99%

Artificial placenta: Recent advances and potential clinical applications

Metelo‐Coimbra

Roncon‐Albuquerque

2016

Pediatric Pulmonology

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Lung immaturity remains a major cause of morbidity and mortality in extremely premature infants. Positive-pressure mechanical ventilation, the method of choice for respiratory support in premature infants, frequently promotes by itself lung injury and a negative impact in the circulatory function. Extracorporeal lung support has been proposed for more than 50 years as a potential alternative to mechanical ventilation in the treatment of severe respiratory failure of extremely premature infants. Recent advances in this field included the development of miniaturized centrifugal pumps and polymethylpentene oxygenators, as well as the successful use of pump-assisted veno-venous extracorporeal gas exchange systems in experimental artificial placenta models. This review, which includes studies published from 1958 to 2015, presents an update on the artificial placenta concept and its potential clinical applications. Special focus will be devoted to the milestones achieved so far and to the limitations that must be overcome before its clinical application. Notwithstanding, the artificial placenta stands as a promising alternative to mechanical ventilation in extremely premature infants. Pediatr Pulmonol. 2016;51:643-649. © 2016 Wiley Periodicals, Inc.

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“…Mark Schoberer et al. of RWTH Aachen University, Aachen, Germany reviewed 50 years of work on the artificial placenta for neonatal intensive care. Recent advances in oxygenator technology have allowed exploration of the simpler and physiologically preferable concept of pumpless arteriovenous oxygenation.…”

Section: Cardiopulmonary Support and Membrane Oxygenationmentioning

confidence: 99%

Artificial Organs 2012: A Year in Review

Malchesky¹

2013

Artificial Organs

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In this editor's review, articles published in 2012 are organized by category and briefly summarized. We aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. As the official journal of the International Federation for Artificial Organs, the International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ replacement, recovery, and regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide such meaningful suggestions to the author's work whether eventually accepted or rejected, and especially to those whose native tongue is not English. Without these excellent and dedicated reviewers, the quality expected from such a journal could not be possible. We also express our special thanks to our publisher, Wiley Periodicals, for their expert attention and support in the production and marketing of Artificial Organs. We look forward to recording further advances in the coming years.

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Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Cited by 26 publications

References 18 publications

An extra-uterine system to physiologically support the extreme premature lamb

An extra-uterine system to physiologically support the extreme premature lamb

Artificial placenta: Recent advances and potential clinical applications

Artificial Organs 2012: A Year in Review

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