Fifty Years of Ophthalmic Laser Therapy

Palanker, Daniel

doi:10.1001/archophthalmol.2011.293

Cited by 33 publications

(17 citation statements)

References 93 publications

(95 reference statements)

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“…In ophthalmology, this method is used for selective treatments of sub-foveal choroidal neovascularization (CNV) which affects patients with age-related macular degeneration (AMD) (Section 3.4) or high myopia (Section 3.1). 2 Overview of laser-assisted procedures in refractive surgery. Un- Table 10.…”

Section: Laser Systems Based On Photochemical Interactionsmentioning

confidence: 99%

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Laser Systems for Treatment of Eye Diseases and Refractive Errors

Kaschke

Donnerhacke²,

Rill

2014

Optical Devices in Ophthalmology and Optometry

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Section: Laser Systems Based On Photochemical Interactionsmentioning

confidence: 99%

“…These difficulties were overcome by PDT, which was introduced by Ursula Schmidt-Erfurth et al and Gilbert Kliman et al in 1994 (Table 10.3). Data taken from [2,3]. Treatments in the foveal region thus became possible as well.…”

Section: Refractive Surgery Technique Laser Procedures (Section) Lasermentioning

confidence: 99%

Laser Systems for Treatment of Eye Diseases and Refractive Errors

Kaschke

Donnerhacke²,

Rill

2014

Optical Devices in Ophthalmology and Optometry

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“…As an alternative and efficient localized therapy, we have investigated a laser‐induced plasmon‐mediated treatment which offers the advantage of producing a highly localized heat increase in the cancerous cells, resulting in cell membrane disruption while avoiding any side effects on healthy tissues . Whether it is for photocoagulation, or for re‐shaping the lens, laser therapy is nowadays a very common technique used by ophthalmologists . Closely related to the technique that we are presenting here, the vitreolysis is a widely used laser‐based technique to eliminate floaters in the vitreous.…”

Section: Introductionmentioning

confidence: 99%

Laser‐induced plasmon‐mediated treatment of retinoblastoma in viscous vitreous phantom

Darviot

Hardy

Meunier

2019

Journal of Biophotonics

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Retinoblastoma (RB) is a rare form of cancer of the retina most prevalent in young children. We successfully show that laser-induced cell disruption, mediated by gold plasmonic nanoparticle (NP), is a potential and efficient therapy to kill the cancerous cells. The proof of concept is demonstrated in vitro on cultured Y79 RB cancer cells with a nanosecond laser at 527 nm, for both attached cells at the bottom of a Petri dish and for floating, clustered cells in a viscous vitreous phantom comprised of hyaluronan. We report a cellular death of 82% after irradiation in classic culture medium and a cellular death of 98% in vitreous phantom, for similar number of NPs in each sample. It is found that the NPs efficiently penetrate the floating Y79 clusters cells in the vitreous phantom, leading to a cellular death of over 85% even within the centre of the aggregates. The proposed treatment technique is based on a similar nanosecond laser used to eliminate floaters in the vitreous, but with much lower (100-1000 times) fluences of 20 J cm −2 . K E Y W O R D Scancer, gold nanoparticles, retinoblastoma, vitreous phantom

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“…These properties of lasers allow them to be a critical therapeutic tool in many fields of medicine, particularly in retinal diseases (Figure 1). Lasers have been used to treat various retinal conditions, including proliferative diabetic retinopathy, diabetic macular edema, central serous chorioretinopathy, central and branch retinal vein occlusions, sickle cell retinopathy, and age-related macular degeneration, since it was first described over 55 years ago [1]. Moreover, retinal laser photocoagulation has been the gold-standard of care for some of these retinal diseases for almost half a…”

Section: Introductionmentioning

confidence: 99%

Innovations in Retinal Laser Technology

Xie¹,

Liu²,

Paulus³

2018

OPJ

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Retinal laser photocoagulation is a proven, effective treatment for various retinal disorders, including diabetic retinopathy, retinal vein occlusions, and sickle cell retinopathy. To minimize iatrogenic retinal damage while maintaining therapeutic effects, retinal laser technology has evolved significantly since its introduction in ophthalmology more than half a century ago. These innovations have included both optimizations of laser parameters in addition to the development of novel laser delivery systems. This review summarizes recent innovations in retinal laser technology, including subthreshold micropulse laser, selective retinal therapy and nanosecond laser, innovative modes of laser delivery including pattern scanning laser, endpoint management, navigated laser, and newly described photo-mediated ultrasound therapy.

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Fifty Years of Ophthalmic Laser Therapy

Cited by 33 publications

References 93 publications

Laser Systems for Treatment of Eye Diseases and Refractive Errors

Laser Systems for Treatment of Eye Diseases and Refractive Errors

Laser‐induced plasmon‐mediated treatment of retinoblastoma in viscous vitreous phantom

Innovations in Retinal Laser Technology

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