Fifteen Years' Experience of the Brazilian Osteosarcoma Treatment Group (BOTG): A Contribution from an Emerging Country

Petrilli, Antônio Sérgio; Brunetto, Algemir Lunardi; Cypriano, Mônica; Ferraro, Alexandre Archanjo; Macedo, Cristiane R; Senerchia, Andreza Almeida; Almeida, Maria Tereza Assis de; Costa, Cecília Maria Lima da; Lustosa, Daniel; Borsato, Maria Luiza; Calheiros, L. M.; Barreto, José Henrique Silva; Epelman, Sidnei; Carvalho, Eny; Alves, Maria Teresa Seixas; Petrilli, Marcelo de Toledo; Penna, Valter; Pericles, P.; Camargo, Olavo Pires de

doi:10.1089/jayao.2013.0012

Cited by 15 publications

(19 citation statements)

References 22 publications

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“…Nine of the 35 Mexican American patients were preadolescents at diagnosis and to the best of our knowledge this is the largest series composed of such patients. In this study, the 5-year EFS of 48% was similar to results from the Brazilian Osteosarcoma Treatment Group who reported a 5-year EFS of only 53% 5. In this cohort, the 5-year EFS was inferior to a smaller study completed on patients in low-income countries in Latin America 6.…”

Section: Discussionsupporting

confidence: 80%

Characterization of Localized Osteosarcoma of the Extremity in Children, Adolescents, and Young Adults From a Single Institution in South Texas

Sugalski

Jiwani

Ketchum

et al. 2014

Journal of Pediatric Hematology/Oncology

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Background:Osteosarcoma is the most common bone malignancy in children, adolescents, and young adults. Most study cohorts have 10% to 15% Hispanic patients that encompass many different Hispanic backgrounds. This study characterizes the effect of mainly Mexican American ethnicity on the outcome of children, adolescents, and young adults with osteosarcoma.Methods:A retrospective analysis of demographics, tumor characteristics, response to treatment, and survival outcome of all localized osteosarcoma of the extremity patients below 30 years of age was performed. A Kaplan-Meier estimates with log-rank tests and Cox proportional hazard regression models were used.Results:Fifty patients (median age, 15; range, 2 to 28 y) with localized high-grade osteosarcoma of the extremity were diagnosed between January 2000 and December 2010. The cohort was 70% Mexican Americans. With a median follow-up of 39 months (range, 5 to 142 mo), patients had a 5-year overall survival and event-free survival of 65% and 48%, respectively. We observed a significantly decreased 5-year event-free survival in patients diagnosed before age 12 relative to patients diagnosed between ages 12 and 29 (11% vs. 57%, P<0.001). We also found that tumor necrosis was not predictive of outcome in our patients.Conclusions:The preadolescent patients of predominately Mexican American ethnicity had an increased rate of relapse when compared with previous studies. Tumor necrosis is not directly predictive of outcome in this population.

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Section: Discussionsupporting

confidence: 80%

Characterization of Localized Osteosarcoma of the Extremity in Children, Adolescents, and Young Adults From a Single Institution in South Texas

Sugalski

Jiwani

Ketchum

et al. 2014

Journal of Pediatric Hematology/Oncology

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“…With the implementation of specialized centers capable of treating children with bone cancers across the country, less people move from their homes to receive treatment. Moreover, the Brazilian Osteosarcoma Treatment Group (BOTG) and the Brazilian Collaborative Study Group for the Treatment of Ewing Sarcoma Family Tumors (EWING1) have been collaborating to improve diagnosis and treatment (14,15). Considering the size of Brazilian population, for children and AYA, we would expect 360 and 180 new cases of OS and ES, respectively, per year.…”

Section: Discussionmentioning

confidence: 99%

Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil

Balmant¹,

Reis²,

Santos³

et al. 2019

Clinics

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OBJECTIVES: Bone cancers occur frequently in children, adolescents, and young adults aging 15 to 29 years. Osteosarcoma and Ewing sarcoma are the most frequent subtypes in this population. The aim of this study was to describe incidence and mortality trends of bone cancers among Brazilian children, adolescents and young adults. METHODS: Incidence information was obtained from 23 population-based cancer registries. Mortality data were extracted from the Atlas of Cancer Mortality from 1979 to 2013. Specific and adjusted rates per million were analyzed according to gender, morphology and age at diagnosis. Median rates were used as a measure of central tendency. Joinpoint regression was applied to analyze trends. RESULTS: Median incidence rates were 5.74 and 11.25 cases per million in children and young adults respectively. Osteosarcoma in the 15-19 years aged group had the highest incidence rates. Stable incidence rates were observed among five registries in 0-14 year's age group. Four registries had a decreased incidence trend among adolescents and young adults. Median mortality rates were 1.22 and 5.07 deaths per million in children and young adults respectively. Increased mortality was observed on the North and Northeast regions. Decreased mortality trends were seen in the South (children) and Southeast (adolescents and young adults). CONCLUSION: Osteosarcoma and Ewing Sarcoma are the most incident bone cancers in all Brazilian regions. Bone cancers showed incidence and mortality patterns variation within the geographic regions and across age groups, although not significant. Despite limitations, it is crucial to monitor cancer epidemiology trends across geographic Brazilian regions.

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“…Overall five-year survival was 55.3%. 3,19 . In addition, the studied group presented characteristics similar to those reported in the BOTG V and GCBTO 2006 studies, with a high prevalence of metastasis and a survival rate of approximately 55% 19 .…”

Section: Global Analysismentioning

confidence: 99%

“…3,19 . In addition, the studied group presented characteristics similar to those reported in the BOTG V and GCBTO 2006 studies, with a high prevalence of metastasis and a survival rate of approximately 55% 19 . Survival rates for metastases, recurrence, and gender (male) followed the pattern and approximate values found in other studies, although they were not statistically significant (probably due to the small sample size) 3,19 .…”

Section: Global Analysismentioning

confidence: 99%

Expressão de neurotrofinas e de seus receptores no osteossarcoma primário.

Antunes

Becker

Brunetto

et al. 2019

Rev. Col. Bras. Cir.

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RESUMO Objetivo: determinar a expressão de neurotrofinas e seus receptores tirosina quinases em pacientes com osteossarcoma (OS) e sua correlação com desfechos clínicos. Métodos: biópsias de tumores primários de pacientes com OS tratados em uma única instituição, consecutivamente, entre 2002 e 2015, foram analisados através de imuno-histoquímica para expressão de receptores de tirosina quinase A e B (TrKA e TrKB), fator de crescimento neural (NGF) e fator neurotrófico derivado do cérebro (BDNF). De forma independente, dois patologistas classificaram os marcadores de imuno-histoquímica como negativos (negativos e focais fracos) ou positivos (moderado focal/difuso ou forte focal/difuso). Resultados: foram analisados dados de 19 pacientes (10 do sexo feminino e 9 do masculino) com mediana de idade de 12 anos (5 a 17,3 anos). Dos tumores, 83,3% estavam localizados em membros inferiores e 63,2% dos pacientes eram metastáticos ao diagnóstico. A sobrevida global em cinco anos foi de 55,3%. BDNF foi positivo em 16 pacientes (84%) e NGF em 14 pacientes (73%). TrKA e TrKB apresentaram coloração positiva em quatro (21,1%) e oito (42,1%) pacientes, respectivamente. A análise de sobrevida não demonstrou diferença significativa entre receptores TrK e neurotrofinas. Conclusão: amostras de OS primário expressam neurotrofinas e receptores TrK através de imuno-histoquímica. Estudos futuros podem auxiliar na identificação do papel das mesmas na patogênese do OS e determinar se há possível correlação prognóstica.

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Fifteen Years' Experience of the Brazilian Osteosarcoma Treatment Group (BOTG): A Contribution from an Emerging Country

Cited by 15 publications

References 22 publications

Characterization of Localized Osteosarcoma of the Extremity in Children, Adolescents, and Young Adults From a Single Institution in South Texas

Characterization of Localized Osteosarcoma of the Extremity in Children, Adolescents, and Young Adults From a Single Institution in South Texas

Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil

Expressão de neurotrofinas e de seus receptores no osteossarcoma primário.

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