Fifteen-Year Trends in Risk Severity and Operative Mortality in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery

Ivanov, Joan; Rd, Weisel; Te, David; Cd, Naylor

doi:10.1161/01.cir.97.7.673

Cited by 147 publications

(85 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19) The highest rise in the number of incidence of coronary artery disease was recorded in the age group of 85 years and above. 20,21) They usually have more severe coronary artery disease, presence of comorbidities and the worse overall preoperative status (higher incidence of the left main coronary artery disease, multivessel disease, left ventricular dysfunction, previous cardiac operations, often accompanied with valvular disease).…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients of Different Age Groups before and after Coronary Artery By-Pass Surgery

Perić¹,

Jovanović-Marković²,

Perić³

et al. 2015

ATCS

View full text Add to dashboard Cite

Purpose: The study evaluates the changes in quality of life (QOL) six months after coronary artery bypass grafting (CABG) related to the patients' age. Methods: The total of 243 consecutive patients completed the Nottingham Health Profile Questionnaire part 1 before and six months after CABG. Postoperative questionnaire was completed by 226 patients. Patients were divided into four examined groups (<50, 50-59, 60-69 and ≥70 years), according to their age. Results: Six months after CABG, the quality of life in different sections has been significantly improved in most patients.The analysis of the relation between the age and the changes in QOL of patients six months after CABG showed a significant correlation among the patients' age and the improvement of QOL in the sections of physical mobility (r = 0.18, p = 0.008), social isolation (r = 0.17, p = 0.01) and energy ( r = 0.21, p = 0.002). The most prominent improvement was found in older patients. The age was not an independent predictor of QOL deterioration after CABG. Conclusions: The most noticeable improvement of QOL six months after CABG was found in older patients. Age is not the independent predictor of deterioration of QOL after CABG.

show abstract

Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients of Different Age Groups before and after Coronary Artery By-Pass Surgery

Perić¹,

Jovanović-Marković²,

Perić³

et al. 2015

ATCS

View full text Add to dashboard Cite

show abstract

“…Another explanation for the increase in ARF-D incidence is that severe ARF may be more commonly observed in modern medical practice. The increasing disease severity and comorbidity of the hospitalized population, expanded use of percutaneous coronary interventions (26) and coronary artery bypass grafting (27) in older and sicker patients, and increasing incidence of sepsis (28) among other factors could be contributing to these trends.…”

Section: Discussionmentioning

confidence: 99%

Declining Mortality in Patients with Acute Renal Failure, 1988 to 2002

Waikar

Curhan²,

Wald³

et al. 2006

Journal of the American Society of Nephrology

526

377

View full text Add to dashboard Cite

“…2,3 This rate is likely to increase further, as patients undergoing cardiac surgery are increasingly older and have more co-morbidity. 4,5 Strategies that prevent acute kidney injury should, therefore, confer important benefits.…”

mentioning

confidence: 99%

N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency

Wijeysundera

Beattie

Rao

et al. 2007

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose: N-acetylcysteine may prevent acute kidney injury after cardiac surgery. To determine if N-acetylcysteine warrants definitive evaluation in a large multicentre trial, we evaluated its effects on a surrogate outcome, estimated glomerular filtration rate (eGFR), in a randomized trial. Methods:One-hundred-seventy-seven cardiac surgery patients with moderate pre-existing renal insufficiency (eGFR ≤ 60 mL·min -1 ) were recruited in a blinded (patients, clinicians, datacollectors) placebo-controlled randomized trial. Eighty-nine were randomized to N-acetylcysteine (100 mg·kg -1 iv bolus, 20 mg·kg -1 ·hr -1 infusion until four hours after cardiopulmonary bypass), and 88 to placebo. The primary outcome was the percent change in eGFR during the first 72 postoperative hours. Secondary outcomes included renal replacement therapy, mortality, atrial fibrillation, vasoactive medications, and adverse effects. A future multicentre trial was deemed to be warranted if N-acetylcysteine was associated with a percent change in eGFR that was 3.8 better (small benefit), and with an upper 95% confidence interval including 9.5 (moderate benefit). Results: The median percent change in eGFR was 5.2% better (absolute difference) in the N-acetylcysteine arm (95% confidence interval 2.4% worse to 12.1% better; P = 0.22). With regard to secondary outcomes, all-cause mortality was lower in the N-acetylcysteine arm (0% vs 8%; P = 0.007). Conclusion:N-acetylcysteine did not cause a statistically significant improvement in postoperative eGFR in this singlecentre study. Nonetheless, its treatment effect was consistent with a plausible small-to-moderate benefit. Given this finding, N-acetylcysteine should be definitively evaluated in a large randomized trial.

show abstract

Fifteen-Year Trends in Risk Severity and Operative Mortality in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery

Cited by 147 publications

References 35 publications

Quality of Life in Patients of Different Age Groups before and after Coronary Artery By-Pass Surgery

Quality of Life in Patients of Different Age Groups before and after Coronary Artery By-Pass Surgery

Declining Mortality in Patients with Acute Renal Failure, 1988 to 2002

N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency

Contact Info

Product

Resources

About