Field trials with cefoperazone in the treatment of bovine clinical mastitis

Wilson, Claire; Agger, Nicolai; Gilbert, G A; Thomasson, C A; Tolling, S.

doi:10.1136/vr.118.1.17

Cited by 18 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Critérios bacteriológicos para avaliar o nível de cura das infecções da glândula mamária após tratamento com antimicrobianos foram propostos por Wilson et al (1986) e Sol et al (1997). Segundo Wilson et al (1986), uma cultura bacteriológica negativa após 14 dias é suficiente para avaliar a recuperação da glândula, entretanto, Sol et al (1997) sugerem duas culturas negativas entre os dias 14 e 30.…”

Section: Resultsunclassified

“…Segundo Wilson et al (1986), uma cultura bacteriológica negativa após 14 dias é suficiente para avaliar a recuperação da glândula, entretanto, Sol et al (1997) sugerem duas culturas negativas entre os dias 14 e 30. Esses autores observaram recidivas após 30 dias do tratamento em infecções produzidas por S. aureus.…”

Section: Resultsunclassified

“…Os índices de recuperação da glândula variam entre 3,6% e 92% (Wilson, 1986;Tyler et al, 1992;Owens et al, 1993;Ratnakumar et al, 1996;Sol et al, 1997;Friton et al, 1998). Em alguns experimentos os resultados não foram considerados significativos (McDermontt et al, 1983;Seymour et al, 1989).…”

Section: Introductionunclassified

See 2 more Smart Citations

Antibioticoterapia para controle da mastite subclínica de vacas em lactação

Reis

Silva²,

Brescia³

2003

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Avaliou-se a eficiência da antibioticoterapia como estratégia para o controle de mastite subclínica em animais em lactação. Foram tratados 83 tetos infectados de 31 animais de três propriedades leiteiras, divididos em dois estádios da lactação:15 a 100 dias (grupo I) e 101 a 200 dias (grupo II), com aplicação intramamária de 250mg de cefacetril sódico (cefalotina). A droga permaneceu 24 horas dentro dos quartos do úbere dos animais tratados. Vinte e oito tetos de 14 animais infectados foram mantidos como controle, sem tratamento. Os grupos tratados e controle foram avaliados nos dias zero, 14, 25 e 40 após o tratamento por meio de provas de California Mastitis Test (CMT), contagem de células somáticas (CCS), isolamento e identificação de patógenos e produção leite. Staphylococcus aureus e Staphylococcus coagulase-negativo foram os microrganismos mais isolados (43,1%), seguidos por Bacillus spp, Corynebacterium bovis, Streptococcus uberis e Escherichia coli. Quatorze dias após o tratamento houve redução de 61,4% das infecções intramamárias e acentuada diminuição da CCS e de reações positivas ao CMT nos animais tratados, nos dois estádios da lactação. Entre os dias 25 e 40 após tratamento as diferenças não foram significativas (P> 0,05). Ocorreram recidivas ou reinfecções nos tetos tratados. O aumento de produção de leite não foi significativo entre os animais tratados (P> 0,05). A antibioticoterapia durante a lactação não foi efetiva para o controle das mastites subclínicas, mesmo em animais que apresentaram alta contagem de células somáticas.

show abstract

Section: Resultsunclassified

See 1 more Smart Citation

Antibioticoterapia para controle da mastite subclínica de vacas em lactação

Reis

Silva²,

Brescia³

2003

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“…In high-yielding dairy cows, 2 syringes of intra-mammary antibiotic preparation may be infused initially into the affected quarter. The introduction of cefoperazone for intra-mammary administration with single-dose treatment is a significant advance to treat sub-acute form of mastitis [129].…”

Section: Sub-acute Clinical Mastitismentioning

confidence: 99%

Bovine Mastitis and Its Therapeutic Strategy Doing Antibiotic Sensitivity Test

Mk¹

2017

Austin J Vet Sci & Anim Husb

View full text Add to dashboard Cite

Mastitis is one of the most costly devastating diseases in the dairy industry. Bovine mastitis can be classified as clinical or subclinical based on clinical features of the disease. Subclinical mastitis occurrence is more prominent compared to clinical form and its prevalence is more than 20 to 50% of cows in given herds. Both forms cause substantial financial losses due to reduced milk yield, degraded milk quality, drug costs and veterinary expenses, early culling of cows and increased labour costs for the farmers. The chief causal organisms of mastitis are cell-walled bacteria, even though mycoplasma, algae and yeast have also been identified to cause mastitis. Numerous influencing factors like physiological, pathological, environmental or genetic factors may contribute to the occurrence of mastitis in dairy cattle. Presently, different types of antibiotics are prescribed for the treatment of mastitis. However, therapeutic success rate of mastitis is generally poor because of pathological changes in the udder parenchyma, mastitogenic bacterial and related factors, indiscriminate use of antibiotics and poor animal husbandry practices. These evidences focus the necessity for discovering completely newer strategies for treatment of mastitis. This review will highlight the key etiological agents and factors affecting the manifestation of mastitis, and the recent advancement of therapeutic strategies including application of antibiotic-based therapies by doing antibiotic sensitivity test as a prospective approach to prevent and control mastitis in dairy herds.

show abstract

“…Multidose intramammary syringes should be avoided for hygienic reasons. The introduction of cefoperazone for intramammary administration with single-dose treatment is a significant advance 59 . Parenteral antibiotic therapy is not routinely advocated but may be indicated in the circumstances mentioned for subclinical mastitis 1,22,32,46,47,50 .…”

Section: Subacute Clinical Mastitismentioning

confidence: 99%

Bovine mastitis therapy and why it fails : continuing education

Preez¹

2000

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

Treatment of bovine mastitis depends on the cause, the clinical manifestation and the antibiotic susceptibility of the agent. Mastitis therapy is commonly unsuccessful owing to pathological changes that occur in the udder parenchyma as a result of the inflammatory reaction to mastitogenic bacteria, pharmacokinetic properties of antimicrobial mastitis drugs, mastitogenic bacterial and related factors, and poor animal husbandry and veterinary interventions.Key words: infectious bovine mastitis, mastitogenic bacterial factors, mastitis therapy, pathological udder changes, pharmacokinetic properties, poor animal husbandry. activity 2 . However, the blood circulation through the udder of a cow producing 20 kg of milk per day is approximately 10 000 /d, or 7-10 /min 22 . Systemic administration of rationally selected antibacterials can therefore be used as the sole treatment in acute mastitis. Following systemic administration, basic drugs (if sufficiently lipid-soluble) tend to concentrate in milk. The non-ionised fraction reaches equal concentrations on either side of the the blood-milk barrier 29 , even when marked udder changes are present.An ideal antibiotic for parenteral mastitis therapy should have a low MIC against the majority of udder pathogens, high bioavailability via the intramuscular route, sufficient lipid solubility, a low degree of serum protein binding, a long half-life in the body, similar clearance from organs, tissues and blood, no distribution to the gastrointestinal tract, and be weakly basic or otherwise highly nonionised in serum 40,49,67 . To date, as far as we know, no single antibiotic meets all these requirements.Therapy of acute mastitis should commence as soon as possible after diagnosis 12,58 , using a highly bioavailable antibiotic, with the necessary supportive therapy 41 . The milder the pathology in the udder parenchyma, the better the prognosis.The duration of treatment depends on the clinical symptoms, medical history of the cow and microbiological diagnosis. Lengthy treatment means a lengthy milk withdrawal period, which makes the treatment costly. If the cow has chronic mastitis that cannot be cured during lactation, culling is the obvious solution. However, sufficiently lengthy treatment of a cow with a good prognosis may lead, in addition to clinical recovery, to elimination of the bacteria from the udder.All cows that have had clinical mastitis during lactation should be given dryingoff therapy. SPECIFIC THERAPY FOR THE VARIOUS FORMS OF MASTITIS Teat canal infection (TCI)Treating lactating cows with small quantities of antibiotic (1 to 2 droplets) introduced 3 times at 12-hourly intervals effectively eliminates teat canal infection 9,10 . Teat canal therapy is not advocated commercially. A high percentage of TCI (> 50 %) undergo spontaneous recovery (self-cure) when predisposing factors to mastitis are limited or eliminated 9 . Subclinical mastitisFor treatment to make a significant contribution to reducing the incidence of mastitis, it is necessary to treat subclini...

show abstract

Field trials with cefoperazone in the treatment of bovine clinical mastitis

Cited by 18 publications

References 0 publications

Antibioticoterapia para controle da mastite subclínica de vacas em lactação

Antibioticoterapia para controle da mastite subclínica de vacas em lactação

Bovine Mastitis and Its Therapeutic Strategy Doing Antibiotic Sensitivity Test

Bovine mastitis therapy and why it fails : continuing education

Contact Info

Product

Resources

About