Field survey on types of organic solvents used in enterprises of various sizes

Samoto, Hajime; Fukui, Yoshinari; Ukai, Hirohiko; Okamoto, Susumu; Takada, Shiro; Ohashi, Fumiko; Moriguchi, Jiro; Ezaki, Takafumi; Ikeda, Masayuki

doi:10.1007/s00420-005-0082-3

Cited by 26 publications

(44 citation statements)

References 56 publications

(57 reference statements)

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“…and Kumai et al 10) were different from those in other studies 11,13,14) (including the present study) in the sense that direct injection (into a gas-chromatograph) of the homogeneous preparations (such as thinners and degreasers) was employed by Inoue et al 9) , and headspace air in vessels containing heterogeneous preparations (e.g., inks and paints) was analyzed by Kumai et al 10) for solvent component analyses. The use of solvents as a mixture has been a typical pattern of solvent use in various industries.…”

Section: Discussioncontrasting

confidence: 64%

“…The target solvents were Group 1 (7 types) and Group 2 (40 types) solvents as prescribed in the Ordinance for Prevention of Organic Solvent Poisoning (Table 1 19,20) ), similar to the previous publications [11][12][13][14] ; Group 3 solvents were not measured as they are natural solvent mixtures 11,14) . The methods of workroom air sampling (by the Tedlar bag method) and instrumental analyses (by capillary gas-chromatography) were in accordance with regulatory standards, as previously described in details 11,14) .…”

Section: Analysis For Solvent Vapors In Workroom Airmentioning

confidence: 82%

“…The methods of workroom air sampling (by the Tedlar bag method) and instrumental analyses (by capillary gas-chromatography) were in accordance with regulatory standards, as previously described in details 11,14) .…”

Section: Analysis For Solvent Vapors In Workroom Airmentioning

confidence: 99%

“…This study group has been compiling data on solvent components commonly detected in various workplaces in enterprises since 1980s [9][10][11][12][13][14] . The historical data will be compared in the present report with the results of the latest air analysis to clarify trends in the types of solvents in solvent workplaces.…”

Section: Introductionmentioning

confidence: 99%

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Organic Solvent Use in Enterprises in Japan

et al. 2011

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This study was initiated to elucidate possible changes in types of organic solvents (to be called solvents in short) used in enterprises in Japan through comparison of current solvent types with historical data since 1983. To investigate current situation in solvent use in enterprises, surveys were conducted during one year of 2009 to 2010. In total, workroom air samples in 1,497 unit workplaces with solvent use were analyzed in accordance with regulatory requirements. Typical use pattern of solvents was as mixtures, accounting for >70% of cases. Adhesives spreading (followed by adhesion) was relatively common in small-scale enterprises, whereas printing and painting work was more common in middle-scale ones, and solvent use for testing and research purpose was basically in large-scaled enterprises. Through-out printing, painting, surface coating and adhesive application, toluene was most common (being detected in 49 to 82% of workplaces depending on work types), whereas isopropyl alcohol was most common (49%) in degreasing, cleaning and wiping workplaces. Other commonly used solvents were methyl alcohol, ethyl acetate and acetone (33 to 37%). Comparison with historical data in Japan and literature-retrieved data outside of Japan all agreed with the observation that toluene is the most commonly used solvent. Application of trichloroethylene and 1,1,1-trichloroethane, once common in 1980s, has ceased to exist in recent years.

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Section: Discussioncontrasting

confidence: 64%

Section: Analysis For Solvent Vapors In Workroom Airmentioning

confidence: 82%

Section: Analysis For Solvent Vapors In Workroom Airmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Organic Solvent Use in Enterprises in Japan

et al. 2011

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“…The methods of sampling (with Tedlar bags) and analyses (by capillary gaschromatography) were as previously detailed elsewhere [1][2][3]6) . Group 3 solvents were not taken into account, as they are natural solvent mixtures and do not fit with the gaschromatographic identification 11,13) .…”

Section: Solvents Analyzed In Workroom Airmentioning

confidence: 99%

Solvent Use in Private Research Laboratories in Japan: Comparison with the Use in Public Research Laboratories and on Production Floors in Industries

Hanada

Zaitsu

Kojima

et al. 2014

Journal of Occupational Health

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Direct methyl esterification with 2,2‐dimethoxypropane for the simultaneous determination of urinary metabolites of toluene, xylene, styrene, and ethylbenzene by gas chromatography‐mass spectrometry

Takeuchi

Namera

Sakui

et al. 2019

Journal of Occupational Health

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Objectives The purpose of this study was to develop a simple and accurate gas chromatography‐mass spectrometry (GC‐MS) method for simultaneous determination of four urinary metabolites from four organic solvents, that is, hippuric acid (HA) from toluene, methylhippuric acid (MHA) from xylene, and mandelic acid (MA) and phenylglyoxylic acid (PGA) from styrene or ethylbenzene for biological monitoring. Methods The four metabolites were directly methyl‐esterified with 2,2‐dimethoxypropane and analyzed using GC‐MS. The proposed method was validated according to the US Food and Drug Administration guidance. The accuracy of the proposed method was confirmed by analyzing a ClinChek ® —Control for occupational medicine (RECIPE Chemicals +Instruments GmbH). Results Calibration curves showed linearity in the concentration range of 10‐1000 mg/L for each metabolite, with correlation coefficients >0.999. For each metabolite, the limits of detection and quantification were 3 mg/L and 10 mg/L, respectively. The recovery was 93%‐117%, intraday accuracy, expressed as the deviation from the nominal value, was 92.7%‐103.0%, and intraday precision, expressed as the relative standard deviation (RSD), was 1.3%‐4.7%. Interday accuracy and precision were 93.4%‐104.0% and 1.2%‐9.5%, respectively. The analytical values of ClinChek obtained using the proposed method were sufficiently accurate. Conclusions The proposed method is a simple and accurate which is suitable for routine analyses that could be used for biological monitoring of occupational exposure to four organic solvents.

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Field survey on types of organic solvents used in enterprises of various sizes

Cited by 26 publications

References 56 publications

Organic Solvent Use in Enterprises in Japan

Organic Solvent Use in Enterprises in Japan

Solvent Use in Private Research Laboratories in Japan: Comparison with the Use in Public Research Laboratories and on Production Floors in Industries

Direct methyl esterification with 2,2‐dimethoxypropane for the simultaneous determination of urinary metabolites of toluene, xylene, styrene, and ethylbenzene by gas chromatography‐mass spectrometry

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