Field Studies of Cyclopian Malformations in Sheep

Babbott, Frank L.; Binns, Wayne; Ingalls, Theodore H.

doi:10.1080/00039896.1962.10663252

Cited by 15 publications

(4 citation statements)

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“…Alternatively, the craniofacial features observed might be a consequence of interference with neural crest cell migration into this region (for reviews, see Le Douarin, 1982;Hall, 1988). Similar craniofacial abnormalities have also occurred in sheep as a result of the ingestion of the plant Veratrum californicum (Babbott et al, 1962) and been induced experimentally in animals by a variety of teratogenic agents (e.g. Warkany, 1971;Sulik and Schoenwolf, 1982).…”

Section: Figmentioning

confidence: 90%

New insights into triploidy and tetraploidy, from an analysis of model systems for these conditions

Kaufman

1991

Human Reproduction

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While triploids and tetraploids together probably account for approximately 20% of all spontaneous abortions with a numerical chromosomal defect, and consequently give rise to a significant proportion of human pregnancy wastage, relatively little is known about their early embryogenesis and phenotypic features. We have therefore studied the early post-implantation stages of development of spontaneously occurring digynic triploid mouse embryos and experimentally induced diandric and digynic triploids, as well as diandric heterozygous diploids and homozygous tetraploid embryos. This material has been examined morphologically and cytogenetically, in order to investigate whether any relationship exists between their phenotype, genotype and developmental potential. Attention is drawn to the fact that the detailed analysis of this material has already shed important new light on the genetic factors that influence early mammalian development. In addition, it appears likely that it has the potential to provide new insights into pattern formation, in particular in relation to the craniofacial region, the heart and the post-cranial vertebral axis.

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Section: Figmentioning

confidence: 90%

New insights into triploidy and tetraploidy, from an analysis of model systems for these conditions

Kaufman

1991

Human Reproduction

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“…3 Since the malformations were feared to be caused by genetic defects, the herders further worried that public knowledge of the cyclopic lambs would compromise the commercial value of their other livestock.…”

Section: The Mysterious Case Of “Monkey-faced” Lambsmentioning

confidence: 99%

“…The occurrence of "monkeyfaced" lambs was a signicant economic hardship for the ranchers, with each afflicted animal representing a loss of about US$20 at the time (approximately US$150-US$300 per head today). 3 Since the malformations were feared to be caused by genetic defects, the herders further worried that public knowledge of the cyclopic lambs would compromise the commercial value of their other livestock.…”

Section: The Mysterious Case Of "Monkeyfaced" Lambsmentioning

confidence: 99%

I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

Chen

2016

Nat. Prod. Rep.

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During the 1950s, sheep ranchers in the western United States experienced episodic outbreaks of cyclopic lambs. In this highlight I describe how these mysterious incidents were traced to the grazing of Veratrum californicum wildflowers by pregnant ewes, leading to the discovery of cyclopamine (1) as a plant-derived teratogen. The precise mechanism of cyclopamine action remained enigmatic for 30 years, until this steroid alkaloid was found to be the first specific inhibitor of Hedgehog (Hh) signalling and a direct antagonist of the transmembrane receptor Smoothened (SMO). In addition to being a valuable probe of Hh pathway function, cyclopamine has been used to demonstrate the therapeutic potential of Hh pathway inhibitors. I discuss the development of SMO antagonists as anticancer therapies and emerging challenges.

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“…Furthermore, hereditary cyclopia has been demonstrated in guinea pigs (Wright 1960). Nongenetic factors must also be considered, since the ingestion of certain plants is capable of producing cyclopia in sheep (Binns et al 1962, Babbot et al 1962. Therefore, the etiology of this congenital malformation is complex and both genetic and environmental factors have been implicated.…”

Section: Arakakimentioning

confidence: 99%