Field potential analysis of the inhibitory pattern in a reptilian cerebellar cortex (Lacerta viridis)

Shimono, T.; Kennedy, D.T.; Kitai, S.T.

doi:10.1016/0006-8993(70)90479-8

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…Failure of the antidromic impulse to invade more superficial parts of dendritic trees is indicated by the reversal of ponent resemble those of the action potentials of Purkinje cells evoked orthodromically by Loc stimulation (Fig. 2B) and are in good agreement with those in other works (ECCLES et al, 1967a(ECCLES et al, , 1969LLINAS et al, 1969a;NICHOLSON and LLINA 1969a;SHIMONO et al, 1970). The N2 component with the latency of about 2.5 msec reaches its maximal N2 component is interpreted as representing synaptic currents in granule cells and action currents of their ascending axons.…”

Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 90%

“…The superficial positive spike of the second component (left dotted line in kinje cell somata), and gradually decreases in deeper layers. A similar potential component was already observed in the frog (LLINAs et al, 1967(LLINAs et al, , 1969b and in the lizard (KITAI et al, 1969;SHIMONO et al, 1970). The latency of this spike is about 7.5 msec, which is in good agreement with the average latency of unitary responses of Purkinje cells evoked by Loc stimulation (Shimono, in preparation).…”

Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 87%

“…The spike potentials generated in Purkinje cells may also contribute to the N3 wave at deeper levels of the molecular layer. The depth profile of field potentials elicited by WM stimulation in the frog cerebellar cortex is alike that seen in the cat (ECCLES et al, 1967a) and also similar to those obtained in other animals (ECCLES et al, 1969;NICHOLSON and LLINAS, 1969a;SHIMONO et al, 1970).…”

Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 81%

“…Electrophysiological and histological investigations of the frog cerebellum were made by MATTHEWS et al (1958) and GLEES et al (1958). After these studies, there have been many comparative works of the neuronal mechanism in the cerebellar cortices of various vertebrates (LLINAS and BLOEDEL, 1967;LLINA and NICHOLSON, 1969;BLOEDEL and LLINAS, 1969;ECCLES et al, 1969ECCLES et al, , 1970KITAI et al, 1969;NICHOLSON and LLINAS, 1969a, b;SHIMONO et al, 1970;FABE and KORN, 1970;RUSHMER and WOODWARD, 1971;WOODWARD et al, 1971).…”

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confidence: 99%

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The Inhibitory Mechanism in the Frog Cerebellar Cortex

Shimono

1973

Jpn.J.Physiol

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1) A controversial problem on the inhibitory mechanism in the frog cerebellar cortex was brought to a conclusion by studying cortical field potentials generated by double and combined stimulation of the parallel fiber (Loc) and the white matter (WM). 2) Depth profiles of the field potentials elicited by Loc and WM stimulations were essentially similar to those found in other vertebrates. 3) The field potentials representing antidromic and orthodromic activations of Purkinje cells were inhibited for a period of 100-400 msec by conditioning Loc stimulation. The same was observed by conditioning WM stimulation which was made intense to involve activation of the mossy fiber-granule cell system and climbing fibers. 4) The field potentials of granule cell discharges elicited by WM stimulation were also suppressed for a period of 200-400 msec by conditioning Loc stimulation. 5) It is concluded that two inhibitory mechanisms operate in the frog cerebellar cortex: stellate cell inhibition of Purkinje cells and Golgi cell inhibition of granule cells.

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Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 90%

Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 87%

Section: Laminar Field Potentials Elicited By Loc Stimulationsupporting

confidence: 81%

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confidence: 99%

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The Inhibitory Mechanism in the Frog Cerebellar Cortex

Shimono

1973

Jpn.J.Physiol

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“…In the case of more complex tissues, a will be a symmetric tensor [24]; thus there is always a rotation of the coordinate system to the principal axes, which reduces the tensor to its three main components [25]. It is assumed that the components of the tensor are constant; then, designating the components by ox, ay, and ao, (5) becomes…”

Section: V~~~i=i MImentioning

confidence: 99%

Theoretical Analysis of Field Potentials in Anisotropic Ensembles of Neuronal Elements

Nicholson

1973

IEEE Trans. Biomed. Eng.

118

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Synchronous excitation of an ensemble of elements in the nervous system generates field potentials in and around the ensemble. Experimental analysis of these potentials can provide information about neuronal function. This paper derives a theoretical relationship between field potentials and the volume source current density produced by transmembrane currents of members of the neuronal ensemble, under typical experimental conditions. It is shown to be plausible that the potentials produced by a dense bounded ensemble of excited neuronal elements are adequately represented by Poisson's equation. The ensemble is envisaged as embedded in an anisotropic conductive medium. When the ensemble possesses some anatomical symmetry and is synchronously excited, Poisson's equation may be solved to give the field potential as a one-dimensional weighted integral of the volume source current density. The weighting is a function of the conductivity tensor, the neuronal population geometry, and the location of the observation point relative to the source points. When the neuronal elements are represented by a core conductor model, the field potentials may be computed and are shown to agree with experiments. The present theory should facilitate field potential analysis by demonstrating effects of anisotropy and ensemble geometry in a three-dimensional conductive medium.

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