Field Inversion Gel Electrophoresis for Apolipoprotein(a) Genotyping

Tavridou, Anna; Laker, M. F.

doi:10.1006/abio.1999.4189

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…All samples were stored at − 80 ° C for approximately the same length of time and thawed only before analysis. Field inversion gel electrophoresis (FIGE) followed by Southern blotting and chemiluminescent detection was employed for apo(a) genotyping [22]. The MP-1 probe was used for hybridization [23].…”

Section: Biochemical Measurementsmentioning

confidence: 99%

Predictors of lipoprotein(a) levels in a European and South Asian population in the Newcastle Heart Project

Tavridou

Unwin

Bhopal

et al. 2003

Eur J Clin Investigation

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There were few nongenetic predictors of lipoprotein(a) levels in South Asians and Europeans. The lack of difference in Lp(a) between the South Asian and European men and the fact that differences between the women seemed to be confined to the Pakistani group offer little support to the hypothesis that higher Lp(a) levels contribute to the increased risk of heart disease in South Asians. Our findings do not support the hypothesis that susceptibility to heart disease in South Asians results from a combination of high insulin resistance and high Lp(a) levels.

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Section: Biochemical Measurementsmentioning

confidence: 99%

Predictors of lipoprotein(a) levels in a European and South Asian population in the Newcastle Heart Project

Tavridou

Unwin

Bhopal

et al. 2003

Eur J Clin Investigation

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Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom

Syed¹,

Irving²,

Redfern³

et al. 2004

The Journal of Clinical Endocrinology & Metabolism

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Similarities between clinical states of glucocorticoid excess and obesity have raised suspicion of a link between the two conditions. An Asn363Ser (N363S) polymorphism in exon 2 of the glucocorticoid receptor has been associated with glucocorticoid sensitivity and excess adiposity in people of European origin. Compared with Europid populations, South Asians have a higher prevalence of cardiovascular risk factors, including type 2 diabetes and central obesity. The aim of this study was to determine the prevalence of the 363S allele in people of South Asian origin living in northeast England in relation to obesity and other cardiovascular risk factors. DNA from 142 males and 153 females was characterized for 363S allele status. Two N363S heterozygotes were identified; both subjects had raised body mass index and central obesity. Despite a higher prevalence of overweight (body mass index >/==" BORDER="0"> 25 kg/m(2)) people in the South Asian group compared with the Europid population in the same geographical area (66 vs. 56%, respectively), the 363S allele frequency was significantly lower in the South Asian group (0.3 vs. 3%, respectively). Therefore, the N363S polymorphism is unlikely to be an important factor in obesity and/or dysmetabolic traits in people of South Asian origin living in the United Kingdom.

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Field Inversion Gel Electrophoresis for Apolipoprotein(a) Genotyping

Cited by 2 publications

References 11 publications

Predictors of lipoprotein(a) levels in a European and South Asian population in the Newcastle Heart Project

Predictors of lipoprotein(a) levels in a European and South Asian population in the Newcastle Heart Project

Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom

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