Field-Flow Fractionation: Addressing the Nano Challenge

Abstract

Field-flow fractionation is coming of age as a family of analytical methods for separating and characterizing macromolecules, nanoparticles, and particulates. The capabilities and versatility of these techniques are discussed in light of the challenges that are being addressed in analyzing nanometer-sized sample components and the insights gained through their use in applications ranging from materials science to biology. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.html .).

Analysis of Particle Size Distributions of Quantum Dots: From Theory to Application

“…Regarding the measurement principle, no column is needed but separation rather occurs in a laminar flow channel which is superimposed with an orthogonal second field. This second field is often a flow field, but also thermal, electric, magnetic and gravitational fields are possible (Baalousha M. et al, 2011;Williams S.K.R. et al, 2011).…”

Methods for separation, identification, characterization and quantification of silver nanoparticles

“…Spiked recoveries in real samples were 71. [30]. Because of its extraordinary resolution and applicability to a wide range of sizes, FFF has been used to separate various engineered NMs.…”

Separation and Determination of Silver Nanoparticles

“…FFF is a flow-assisted hydrodynamic separation technique that was designed to separate and size the macromolecular, colloidal, and particulate materials [12][13][14]. The separation process is very similar to chromatography except that the isolation relies on physical forces and without the need of a stationary phase.…”