Field evaluation of the efficacy and safety of emodepside/praziquantel spot–on solution against naturally acquired nematode and cestode infections in domestic cats

Abstract

Two controlled, blinded and randomized multi-site clinical field studies evaluated the efficacy and safety of emodepside/praziquantel spot-on in the treatment of gastrointestinal nematode and cestode infections in cats. In a study conducted in Europe, faecal egg count reductions of >98% for all nematode eggs and eggs of Toxocara cati, respectively, were observed in cats treated with emodepside/praziquantel spot-on (Profender, Bayer AG, Leverkusen, Germany). For a positive-control product containing selamectin (Stronghold) reductions of >95% were observed. A 100% reduction of faecal eggs and proglottids was observed in cats treated with emodepside/praziquantel spot-on that were infected with cestodes. In a study conducted in North America, cats were treated with either emodepside/praziquantel spot-on plus a placebo tablet or a combination of two control products containing, respectively, selamectin (Revolution) and epsiprantel (Cestex). Faecal egg count reduction for eggs of T. cati was >99% for both treatments. For faecal eggs and proglottids of Dipylidium caninum reductions of >99 and >97% were recorded for cats treated with emodepside/praziquantel spot-on and the control group, respectively. No adverse reactions were observed in the European study, and only mild ones of short duration in a few cats from both treatment groups of the North American study. The two studies demonstrated that emodepside/praziquantel spot-on is highly efficacious and safe under field conditions.

Pet roundworms and hookworms: A continuing need for global worming

“…Emodepside is available in a spot on formulation for cats (containing also praziquantel), which has efficacy up to 100% in treating infection by T. cati or T. leonina at different stages [136,137]. This formulation also has 100% efficacy against mature A. tubaeforme and efficacy of >95% and >97% against L4 and immature adults, respectively [138].…”

Gastrointestinal Parasite Infection in Cats in Daegu, Republic of Korea, and Efficacy of Treatment Using Topical Emodepside/Praziquantel Formulation

“…Concerning administration routes, topical treatment with anthelmintics is preferred because it is more convenient and less stressful than oral administration for both cats and their owners [10]. Emodepside 2.1% (w/v) plus praziquantel 8.6% (w/v) (Profender® spot-on, Bayer, Kiel, Germany) is a topically applied anthelmintic drug with broad-spectrum activity.…”

“…It is a derivative of PF1022A, and shows various anthelmintic activities in animals [11]. Praziquantel is a pyrazinoisoquinoline derivative that has shown effectiveness against cestodes in large and small animals [10,12].…”

Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals

“…The efficacy has been confirmed in controlled, blinded, randomized, multi‐site clinical studies where faecal egg count reductions of >98% were demonstrated for nematode (including T. cati ) eggs (Altreuther et al. , 2005b).…”