Field Effect Transistor Based on a Modified DNA Base

Maruccio, Giuseppe; Visconti, Paolo; Arima, Valentina; D'Amico, S.; Biasco, Adriana; D’Amone, Eliana; Cingolani, R.; Rinaldi, R.; Masiero, Stefano; Giorgi, Tatiana; Gottarelli, Giovanni

doi:10.1021/nl034046c

Cited by 127 publications

(82 citation statements)

References 18 publications

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“…However, the deposition of inorganic semiconducting materials as thin films on the electrode surface necessitates relatively expensive and inconvenient techniques, such as the high-vacuum vapor deposition process, which are not applicable to large-area device fabrication. [1] First observed from anthracene in 1963, [2] organic EL initially had low efficiencies and lifetimes of devices compared to inorganic EL. Tang and Van Slyke [3] and Saito et al [4,5] made breakthrough developments, however, using an organic fluorescent dye, which led to a new generation of LEDs in the late 1980s.…”

Section: Methodsmentioning

confidence: 99%

Towards Protein Field‐Effect Transistors: Report and Model of a Prototype

Maruccio¹,

Biasco²,

Visconti³

et al. 2005

Advanced Materials

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Since the early 1970s, the electronics industry has been essentially identified with metal-oxide semiconductor (MOS) large-scale integrated circuits. During the past decades, remarkable advances have been accomplished by the downsizing of components (such as MOS field-effect transistors), and the number of transistors on a chip has continuously increased in accordance with Moore's law thanks to constant improvements in lithographic resolution (the top±down approach). However, this approach is unlikely to be sustainable due to intrinsic physical limitations and to the vast increase in production costs. Molecular electronics was proposed in 1974 by Aviram and Ratner [1] as an alternative bottom±up approach for either standard devices (such as diodes and transistors) or new functional devices. It aims to exploit the unique features of molecular systems, such as the high reproducibility and small size of the building blocks, thermodynamically driven self-assembly, and self-recognition. Today, the obstacles to the development of molecular electronics devices appear more technical than conceptual; [2±4] the main problems are the development of reliable methods to interconnect molecules, to characterize and understand their electronic properties, and to exploit them in real devices. In this work, we take advantage of the redox properties and the functional groups of a protein, blue-copper azurin, to achieve a hybrid transistor based on proteins covalently bonded in ordered layers onto Si/SiO 2 substrates. This is a different and innovative approach with respect to those based on physisorbed monolayers obtained by evaporation or spincoating, or based on single nanosized objects like carbon nanotubes that have serious interconnection problems.[5] The integrity of proteins in dry monolayers is investigated by intrinsic fluorescence spectroscopy, and a model for transport due to the novelty of the material is also proposed. Azurin from P. aeruginosa (Fig. 1b, inset) is a 14.6 kDa blue-copper protein that, in vitro, is able to mediate electron transfer (ET) from cytochrome c 551 to nitrite reductase from the same organism.[ ) is located at one end of the b-barrel-structure protein and at a distance of » 2.6 nm from the copper site. [8] It allows the chemisorption of azurin in oriented monolayers onto crystalline gold or other suitably functionalized surfaces. [9,10] Our prototype structure (Fig. 1a) is a planar metal±insula-tor±metal nanojunction, consisting of two Cr/Au (6 nm thick Cr layer under a 35 nm thick Au layer) arrow-shaped metallic electrodes facing each other at the oxide side of a Si/SiO 2 substrate (drain and source electrodes) and connected by the self-assembled protein monolayer.[11] The nanojunction was fabricated by electron-beam lithography, [12] and a silver gate electrode was deposited on the back of the p-doped Si substrate to form an ohmic bond acting as the back gate in a field-effect transistor (FET) configuration. Both the source± drain separation and the oxide thickness were 100 nm. Typically, aft...

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Section: Methodsmentioning

confidence: 99%

Towards Protein Field‐Effect Transistors: Report and Model of a Prototype

Maruccio¹,

Biasco²,

Visconti³

et al. 2005

Advanced Materials

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“…There are many studies that focus on nanodevices with the integration of nanogap electrodes and organic molecules (small molecules, [153] oligomers, [154,155] polymers, [156] fullerenes, [8,157] and biomolecules, [158][159][160][161] etc.) or other nanometer-sized components (CNTs, [162] nanocrystals, [84,163] etc.)…”

Section: Applicationsmentioning

confidence: 99%

Nanogap Electrodes

2009

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Nanogap electrodes (namely, a pair of electrodes with a nanometer gap) are fundamental building blocks for the fabrication of nanometer‐sized devices and circuits. They are also important tools for the examination of material properties at the nanometer scale, even at the molecular scale. In this review, the techniques for the fabrication of nanogap electrodes, the preparation of assembled devices based on the nanogap electrodes, and the potential application of these nanodevices for analysis of material properties are introduced. The history, the research status, and the prospects of nanogap electrodes are also discussed.

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“…[19] A field-effect transistor based on this supramolecular structure has recently been described. [20] It is worth noting that the ribbon shown in Figure 1e is dipolar and that in the crystal, owing to the parallel packing of the ribbons, these dipoles are parallel. [15] Araki and Yoshikawa recently introduced nonpolar and flexible alkylsilyl groups into 2'-deoxyguanosine to obtain efficient organogelators for alkanes.…”

Section: Introductionmentioning

confidence: 99%

“…Our specific goal was to find out if the carbonyl group in the 5'-O-acylated derivative, which is known to interact through an intra-ribbon Hbond with NH(2), was essential for the formation of nanoribbons. It is worth stressing that the strongly anisotropic quasi-1D nanoribbons were found to possess interesting physicochemical properties, [18][19][20] while the 2D sheetlike assemblies can be expected to hold different yet more modest properties for applications in (opto)electronics. In light of this, it is of paramount importance to find universal strategies to form functional nanoribbons from different guanosine derivatives in order to control and improve the properties of the supramolecular arrangements.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly of an Alkylated Guanosine Derivative into Ordered Supramolecular Nanoribbons in Solution and on Solid Surfaces

Lena

Brancolini

Gottarelli

et al. 2007

Chemistry A European J

Self Cite

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We report on the synthesis and self-assembly of a guanosine derivative bearing an alkyloxy side group under different environmental conditions. This derivative was found to spontaneously form ordered supramolecular nanoribbons in which the individual nucleobases are interacting through H-bonds. In toluene and chloroform solutions the formation of gel-like liquid-crystalline phases was observed. Sub-molecularly resolved scanning tunneling microscopic imaging of monolayers physisorbed at the graphite-solution interface revealed highly ordered two-dimensional networks. The recorded intramolecular contrast can be ascribed to the electronic properties of the different moieties composing the molecule, as proven by quantum-chemical calculations. This self-assembly behavior is in excellent agreement with that of 5'-O-acylated guanosines, which are also characterized by a self-assembled motif of guanosines that resembles parallel ribbons. Therefore, for guanosine derivatives (without sterically demanding groups on the guanine base) the formation of supramolecular nanoribbons in solution, in the solid state, and on flat surfaces is universal. This result is truly important in view of the electronic properties of these supramolecular anisotropic architectures and thus for potential applications in the fields of nano- and opto-electronics.

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Field Effect Transistor Based on a Modified DNA Base

Abstract: In this work, a field effect transistor based on a deoxyguanosine derivative (a DNA base) is demonstrated. Our experiments on transport through the source and drain electrodes interconnected by self-assembled guanine ribbons (Gottarelli et al.

Cited by 127 publications

References 18 publications

Towards Protein Field‐Effect Transistors: Report and Model of a Prototype

Towards Protein Field‐Effect Transistors: Report and Model of a Prototype

Nanogap Electrodes

Self‐Assembly of an Alkylated Guanosine Derivative into Ordered Supramolecular Nanoribbons in Solution and on Solid Surfaces

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