Field Desorption Mass Spectrometry

Beckey, H. D.; Schulten, H.‐R.

doi:10.1002/anie.197504031

Cited by 152 publications

(30 citation statements)

References 55 publications

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“…All of the glycosides presented in this article have been analysed using "soft" ionization mass spectrometry in which ions are produced directly from the solid or liquid state (Lattimer and Schulten, 1989). Field ionization (FI) (Inghram and Gomer, 1955) and field desorption (FD) (Beckey and Schulten, 1975) were two of the pioneering techniques in this arsenal of alternative ionization methods. FD-MS was used extensively for polar and thermolabile molecules until 1983 (Lattimer and Schulten, 1989).…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry of underivatized naturally occurring glycosides

Wolfender

Maillard

Marston

et al. 1992

Phytochemical Analysis

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Mass spectrometry is essential for the structure determination of naturally occurring glycosides. Molecular weight and sugar sequence information can be obtained. Development of “soft” ionization techniques has allowed a direct mass spectrometric investigation of underivatized glycosides. Numerous different and complementary methods of ionization have been used for their study. For a given compound, the choice of a particular technique is crucial in order to obtain the structural information needed. A brief survey of these ionization techniques is given, together with examples of their use in major classes of plant glycosides.

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Section: Introductionmentioning

confidence: 99%

Mass spectrometry of underivatized naturally occurring glycosides

Wolfender

Maillard

Marston

et al. 1992

Phytochemical Analysis

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“…n the 1970s, field desorption (FD) became known as the first soft desorption/ionization method in mass spectrometry (MS) [1][2][3][4]. As documented in the literature [5] and proven by our own experience [6][7][8][9][10][11][12][13], FD-MS performs equally well for the analysis of nonpolar, polar, and ionic compounds.…”

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confidence: 99%

A Liquid Injection Field Desorption/Ionization-Electrospray Ionization Combination Source for a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Linden

Gross

2011

J. Am. Soc. Mass Spectrom.

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A new type of combination ion source has been devised. It unites two complementary ionization methods, i.e., liquid injection field desorption/ionization (LIFDI) and electrospray ionization (ESI). This LIFDI-ESI combination ion source has been constructed for a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The LIFDI-ESI combination ion source can be switched between the LIFDI and ESI modes of operation within 15 min without breaking the vacuum. The source design and its operation are described. LIFDI-FT-ICR spectra of the ionic liquid trihexyl(tetradecyl)-phosphonium tris(pentafluoroethyl)-trifluorophosphate, polyethylene glycol 600, 2,3,4-tridodecyloxy-benzaldehyde, and [60]fullerene are described.

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“…For trace determination of alkali cations the procedure was executed in two steps: First, 3 pL of a standard solution containing a known amount of the alkali halide were applied to the emitter by the modified syringe technique (9) and a signal at the according mle value was recorded. Second, between 0.2 gL and 1 pL of sample were applied t o the same emitter and desorbed under identical conditions.…”

Section: Methodsmentioning

confidence: 99%

Determination of alkali elements by field desorption mass spectrometry

Lehmann¹,

Schulten²

1977

Anal. Chem.

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The determination of cesium in sample sizes of 0.2 to 1 pL in which 0.3 to 1000 pg of the element was present has been achieved by field desorptlon mass spectrometry and single ion monitoring. The preclslon and accuracy of the method were f10% and about f20%, respectively. A sensitivity between 1.4 and 2.5 X lo-' C per pg was obtained for cesium. The sensitivity for detectlon of the other alkali elements was of the same order of magnitude but decreased slightly from cesium to lithium. Cesium was estimated In spectrograde solvents, in body fluids such as saliva and blood, and in environmental samples such as drinking water, seawater, and a natural aerosol.The extraordinary high sensitivity of field desorption (FD) mass spectrometry (MS) for alkali ions was discovered during the early investigations of organic salts ( I ) . The FD spectra obtained always showed the signals for sodium and potassium ions to be several orders of magnitude more intense than all organic ions when the spectra were recorded on photoplates and the emitter temperature was raised to red heat ( 2 ) . Moreover, the signals for sodium and potassium were also observed with high relative abundance in the F D spectra of organic compounds that contained alkali salts as impurities (3-5). The presence of alkali cations [Cat]' in organic samples leads to an attachment to the organic molecule (M) generating stable [M + Cat]' complexes (cationization) (6-8). This process is useful for molecular weight determination and direct isotope analysis of organic compounds.Although there is unanimous agreement between all groups working in the FD-MS field as to the exceptional sensitivity for alkali cations, no analytical application of this phenomenon has been reported to date. This prompted us to investigate the sensitivity and precision of field desorption mass spectrometry in the single ion monitoring mode for quantitative investigations of alkali ions and to exploit the potential of the technique for trace analysis. EXPERIMENTALThe FD ion currents were recorded on a homebuilt single focusing mass spectrometer of low resolution equipped with a FD source with micromanipulator (6). The FD emitter (at +8 kV) was positioned at a distance of 1 mm from the counter electrode (at -4 kV). Only the first lens (at approximately +2 kV) was used for focusing of the ion beam whereas all other deflection plates were at ground potential. With an entrance slit width of 0.1 mm and an exit slit width of 0.5 mm, a resolution of about 300 (10% valley definition) was achieved. This experimental setup simplifies the operation of the FD mass spectrometer considerably because it allows an easy, fast, and reproducible optimizing of the FD ion currents which is particularly relevant for quantitation.The ions were detected using a channel electron multiplier (Valvo) and a combined counter/ratemeter registration unit (Ortec). The chamel electron multiplier was operated at -3 kV.Field anodes employed were 10-pm tungsten wires activated at high temperature ( I ) . The average length of the...

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Field Desorption Mass Spectrometry

Cited by 152 publications

References 55 publications

Mass spectrometry of underivatized naturally occurring glycosides

Mass spectrometry of underivatized naturally occurring glycosides

A Liquid Injection Field Desorption/Ionization-Electrospray Ionization Combination Source for a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Determination of alkali elements by field desorption mass spectrometry

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