Fidelity in planar cell polarity signalling

Ma, Dong; Yang, Chung-Hui; McNeill, Helen; Simon, Michael A.; Axelrod, Jeffrey

doi:10.1038/nature01366

Cited by 317 publications

(600 citation statements)

References 28 publications

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“…6). This is consistent with the fact that Drosophila mutant phenotypes of both ft and ds have short and thick adult legs, despite the fact that ft and ds have distinct expression patterns in Drosophila imaginal discs (Garoia et al, 2000;Ma et al, 2003). These results were not expected if Ds and Ft acted as a traditional ligand and receptor.…”

Section: Formation Of the Ds-ft Gradientsupporting

confidence: 82%

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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How limb size and shape is regulated is a long-standing question in developmental and regeneration biology. Recently, the protocadherin Dachsous-Fat (Ds-Ft) signaling pathway has been found to be essential for wing development of the fly and leg regeneration of the cricket. The Ds-Ft signaling pathway is linked to the Warts-Hippo (Wts-Hpo) signaling pathway, leading to cell proliferation. Several lines of evidence have suggested that the Wts-Hpo signaling pathway is involved in the control of organ size, and that this pathway is regulated by Ds-Ft and Merlin-Expanded, which are linked to morphogens such as decapentaplegic/bone morphogenic protein, Wingless/Wnt, and epidermal growth factor. Here we review recent progress in elucidating mechanisms controlling leg size and shape in insects and vertebrates, focusing on the Ds-Ft signaling pathway. We also introduce a working model, Ds-Ft steepness model, to explain how steepness of the Ds-Ft gradient controls leg size along the proximodistal axis. Developmental Dynamics 240:1028-1041,

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Section: Formation Of the Ds-ft Gradientsupporting

confidence: 82%

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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“…A large body of evidence suggests that Fz has a key role in sensing positional information; although what is upstream of Fz remains unknown. It has been proposed that ft and ds control PCP upstream of Fz/Dsh pathways, and that a gradient of Ft activity sets up the initial asymmetrical localization (Ma et al, 2003;Rawls et al, 2002;Yang et al, 2001), but the origins of the gradient of Ft activity are unknown. One of the most appealing models of positional information is based on the presence of a morphogen-like molecule that would activate Fz in a dose-dependent manner (Adler et al, 2000;Fanto et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Essential role of non-canonical Wnt signalling in neural crest migration

et al. 2005

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Migration of neural crest cells is an elaborate process that requires the delamination of cells from an epithelium and cell movement into an extracellular matrix. In this work, it is shown for the first time that the non-canonical Wnt signalling [planar cell polarity (PCP) or Wnt-Ca2+] pathway controls migration of neural crest cells. By using specific Dsh mutants, we show that the canonical Wnt signalling pathway is needed for neural crest induction, while the non-canonical Wnt pathway is required for neural crest migration. Grafts of neural crest tissue expressing non-canonical Dsh mutants, as well as neural crest cultured in vitro, indicate that the PCP pathway works in a cell-autonomous manner to control neural crest migration. Expression analysis of non-canonical Wnt ligands and their putative receptors show that Wnt11 is expressed in tissue adjacent to neural crest cells expressing the Wnt receptor Frizzled7 (Fz7). Furthermore, loss- and gain-of-function experiments reveal that Wnt11 plays an essential role in neural crest migration. Inhibition of neural crest migration by blocking Wnt11 activity can be rescued by intracellular activation of the non-canonical Wnt pathway. When Wnt11 is expressed opposite its normal site of expression, neural crest migration is blocked. Finally, time-lapse analysis of cell movement and cell protrusion in neural crest cultured in vitro shows that the PCP or Wnt-Ca2+ pathway directs the formation of lamellipodia and filopodia in the neural crest cells that are required for their delamination and/or migration.

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“…We therefore isolated and characterized the expression patterns of several genes encoding members of the PCP pathway in Platynereis. The global module of the PCP pathway includes the atypical cadherins Fat and Dachsous (Ds), and their regulator Four-jointed (Fj), a Golgiassociated kinase 45,46 . This module establishes a polarity at the scale of the tissue via the opposite transcriptional gradients of ds and fj 45,46 .…”

Section: Cns Development Requires Rok-dependent Midline Formationmentioning

confidence: 99%

Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii

et al. 2013

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Signalling pathways are essential for the correct development of the central nervous system (CNS) in bilaterian animals. Here we show that in the CNS of the annelid Platynereis dumerilii, neural progenitor cells (NPCs) are located close to the ventral midline and express axin, a negative regulator of the Wnt/b-catenin pathway. Using pharmacological inhibitors, we observe that Wnt/b-catenin is required for the transition between proliferating NPCs and differentiating neurons. We also show that the Rho-associated kinase (Rok) is necessary for neurectoderm morphogenesis and ventral midline formation, and indirectly affects the distribution of the NPCs and the development of axonal scaffolds. Moreover, seven genes belonging to the planar cell polarity (PCP) pathway are expressed in the developing Platynereis neurectoderm, suggesting an involvement in its morphogenesis. When compared with previous studies in vertebrates, our data suggest that the involvement of the Wnt/b-catenin pathway in the control of neural cell proliferation/differentiation is ancestral to bilaterians.

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Fidelity in planar cell polarity signalling

Cited by 317 publications

References 28 publications

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Essential role of non-canonical Wnt signalling in neural crest migration

Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii

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