Ficus spp. (fig): Ethnobotany and potential as anticancer and anti-inflammatory agents

Lansky, Ephraim Philip; Paavilainen, Helena Maaria; Pawlus, Alison D.; Newman, Robert A.

doi:10.1016/j.jep.2008.06.025

Cited by 264 publications

(190 citation statements)

References 99 publications

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“…The capacity of a chemotherapeutic agent to target malignant cells while preserving normal cells is the hallmark of a promising cancer drug. Increasing evidence from both experimental and clinical studies suggests that a phytochemical-rich diet may interfere with a specific stage of the carcinogenic process [19,20]. Epidemiological evidence shows that consumption of fruits and vegetable is associated with a lowered risk for developing chronic diseases, such cancer, diabetes, Alzheimer's disease, and heart disease.…”

Section: Discussionmentioning

confidence: 99%

Antiangiogenic, Antioxidant and Antiproliferative effects of Common Mediterranean Fruit Extracts with Phytochemical Screening

SS¹

2016

J Drug Res Dev

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Several epidemiological studies have suggested that the Mediterranean dietary pattern, which includes consumption of fruits, has been linked to lower risk of various forms of cancer. This study assessed the antiangiogenic, antioxidant, and antiproliferative properties of extracts from common Mediterranean fruits including, dates (Phoenix dactylifera), figs (Ficus carica), grapes (Vitis vinifera), olives (Olea europaea), and pomegranates (Punica granatum).Different parts of the fruits were extracted with two organic solvents as well as water. Twenty-one extracts were screened for antiangiogenic activity using the rat aorta ring assay. They were tested for cytotoxic activity using four cancer cell lines and one normal cell line, and their antioxidant properties were measured using two methods (2,2'-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric reducing antioxidant power (FRAP) assays). GC-MS analysis indicated the presence of different phytochemical classes in fruits, phenolic acids, sterols, flavonoids, fatty acids, triglycerides, and alkaloids are the main constituents in these fruits. Of the 21 extracts tested, 14 exhibited substantial antiangiogenic effect.The ethanol extracts of pomegranate and olive had the highest activity (100% inhibition at 50 µg/mL), as did the hexane extract of the grape. Likewise, the hexane extract of pomegranate peel and grape seed had the highest cytotoxic effects and was found to induce apoptosis in the colorectal cancer cell line HCT-116. Furthermore, the extracts prepared from ethanol had the highest antioxidant activity among the tested fruits, pomegranate peel displayed potent antioxidant activity, with the lowest IC 50 value calculated (6.06 µg/mL). The study demonstrated considerable anticancer and antioxidant properties in Mediterranean fruit extracts.

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Section: Discussionmentioning

confidence: 99%

Antiangiogenic, Antioxidant and Antiproliferative effects of Common Mediterranean Fruit Extracts with Phytochemical Screening

SS¹

2016

J Drug Res Dev

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“…(Banyan tree) is a large tree with aerial roots and is widely distributed throughout India.Information based on ethnomedicinal survey reveals that the herbal preparations of different parts of Ficus bengalensis (FB) possess medicinal properties and is considered as an effective, economical and safe agent for curing various diseases in Indian traditional system of medicine 5 . Pharmacological investigations of FB indicated the presence of interesting biological activities such as anti-diabetic 6,7 , and anti-bacterial agent 8 .…”

Section: Ficus Bengalensis Lmentioning

confidence: 99%

Protective effect of Ficus bengalensis L. extract against H2O2 induced DNA damage and repair in neuroblastoma cells

et al. 2014

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“…One of the most widely used herbs for medicinal purposes in the Middle East for millennia is the Ficus species (Lansky et al, 2008). Commonly known as fig, several compounds have recently been extracted from the stems of F. formosana f. formosana (Moraceae) and have been shown to have cytotoxicity activity against HepG2, PLC/PRF/5 hepatocellular, and Raji lymphoblastoid cancer cells in vitro (Bisi-Johnson, 2011).…”

Section: Middle Eastmentioning

confidence: 99%

In Vitro Cancer Research on Ancient Herbal Remedies: A Changing Trend

Maness¹

2012

J. App. Pharm. Sci.

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Since cancer is one of the leading causes of death worldwide, accounting for 13% of all deaths, there is a global demand for research to develop new treatments. In search of new cancer preventive and treatment agents, hundreds of plant extracts and compounds have been evaluated for their potential to inhibit cancer cells in vitro, many of which have been used for centuries by native populations from specific geographic regions around the world. Some ancient remedies have now been shown to inhibit the proliferation of specific cancer cells by having a desirable effect at the molecular level. More recently, the number of in vitro gene studies to understand the effects of these herbal medicines on various forms of cancers has increased due to the advancement in molecular techniques. Improved research methods and increased knowledge of the effects of plant extracts on cancer genes is allowing individualistic diagnoses, prognoses, and treatments.

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Ficus spp. (fig): Ethnobotany and potential as anticancer and anti-inflammatory agents

Cited by 264 publications

References 99 publications

Antiangiogenic, Antioxidant and Antiproliferative effects of Common Mediterranean Fruit Extracts with Phytochemical Screening

Antiangiogenic, Antioxidant and Antiproliferative effects of Common Mediterranean Fruit Extracts with Phytochemical Screening

Protective effect of Ficus bengalensis L. extract against H2O2 induced DNA damage and repair in neuroblastoma cells

In Vitro Cancer Research on Ancient Herbal Remedies: A Changing Trend

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