Ficus carica and Bone Health: A Systematic Review

Idrus, Ruszymah Bt Hj; Sainik, Nur Qisya Afifah Veronica; Ansari, Ayu Suraya; Zulfarina, Mohamed S.; Razali, Rabiatul Adawiyah; Nordin, Abid; Saim, Aminuddin Bin; Naina-Mohamed, Isa

doi:10.17576/jsm-2018-4711-17

Cited by 12 publications

(6 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ficus carica (FC) belongs to the family Moraceae, and this plant was initially endemic to West Asia & the Middle East. However, now it is prevalent in different parts of the word (Idrus et al 2018). Numerous plant constituents are exploited for their medicinal properties in treating various ailments, including respiratory, inflammatory, cardiovascular, and gastrointestinal disorders (Bouyahya et al 2016;Idrus et al 2018).…”

Section: Ficus Caricamentioning

confidence: 99%

“…However, now it is prevalent in different parts of the word (Idrus et al 2018). Numerous plant constituents are exploited for their medicinal properties in treating various ailments, including respiratory, inflammatory, cardiovascular, and gastrointestinal disorders (Bouyahya et al 2016;Idrus et al 2018). This plant also has antibacterial, antioxidant (Harzallah et al 2016;Mahmoudi et al 2016), anticancer (Hashemi and Abediankenari 2013;Tian et al 2014), anti-acne (Vaghasiya et al 2015), and antipyretic (Bouyahya et al, 2016) pharmacological properties.…”

Section: Ficus Caricamentioning

confidence: 99%

See 1 more Smart Citation

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

View full text Add to dashboard Cite

Breast carcinoma is a common illness among females. Various therapies, including hormone therapy, surgery, radiotherapy, chemotherapy, and targeted treatment, have been available to treat existing breast cancer. These therapies can potentially halt the development and spread of cancer, especially if the disease is at an early stage, but all these treatments have various adverse effects on human health. Cancer cells proliferate more rapidly than most normal cells, so chemotherapy is the most suitable treatment. Certain medications can cease dividing cells by destroying the cell's control center region. Other drugs can inhibit the chemical processes essential for cell division. On the contrary, because cancer is frequently identified at a late phase, treating the disease is extraordinarily challenging. Therefore, it is advisable to avoid this fatal condition from occurring. Multiple studies have revealed a continuous inverse connection between cancer and natural materials, such as plant extracts, their fractions, and active principles. These bioactive phytochemicals' have synergistic or cumulative effects in the treatment of cancer disease. This review article examined the effect of various extracts/fractions/active principles obtained from diverse plant origins against breast cancer disease. Information regarding the most commonly used plants, including Alpina galaga, Urtica dioica, Annona muricata, Rosmarinus officinalis, Ficus carica, Nigella sativa, Murraya koenigii, and Urtica dioica have been presented in this study. Owing to the information in this study, these plants exhibited anticancer activities in preclinical MCF-7 carcinoma models by decreasing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. The information generated from this review will significantly contribute to developing knowledge of the scientific and medical communities in developing innovative breast cancer treatments.

show abstract

Section: Ficus Caricamentioning

confidence: 99%

Section: Ficus Caricamentioning

confidence: 99%

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

View full text Add to dashboard Cite

show abstract

“…According to the bar chart the experimental group 2 shows the significant effect on fasting and random blood glucose levels of subjects as compared to experimental group 1, group 3 and control group. The therapeutic potential of Ficus carica has led to the extensive studies [22,23] in recent years, focusing on evaluating and validating its pharmacological effect. The leaves of Ficus carica have remarkable health benefits involving antidiabetic activity Table 7 shows the descriptive means + SD of all prepared samples.…”

Section: Proximate Analysis Of Raw Materialsmentioning

confidence: 99%

Development of Chapattis with the Whole Wheat Flour and Fig Leaves for Type II Diabetic Patients

Rafiq

Arif

Sameen

et al. 2021

IHR

View full text Add to dashboard Cite

Diabetes is becoming the major cause of morbidity and mortality throughout the world. Its prevalence throughout the Pakistan population is 11.77%. Medicinal plants and herbs are being used since the ancient times to treat diabetes. One of these plants is fig and its several species are being used for maintaining the blood glucose level. It contains many bioactive compounds such as flavonoids, tannins, vitamin E, sterols, and alkaloids etc. which play important role in regulating blood glucose levels. In the following study, chapattis were developed by fortifying whole wheat flour with fig leaves to check its effectiveness in lowering blood glucose level. Sensory evaluation and proximate analysis of the product was done along with the two different compositions used for the product development. Two biochemical tests – fasting blood glucose level and 2-h postprandial blood glucose level were performed on diabetic patients. The obtained data was subjected to appropriate statistical techniques. The results showed that the chapattis with 15 gm of fig leaves were the most appropriate to consume because chapattis with 10 gm of fig leaves were effective but in the long run whereas chapattis with 20 gm of fig leaves had the tendency to put an individual in hypoglycaemic state.

show abstract

“…The most significant compounds in figs are proteins, fatty acids, enzymes, beta-carotene, ficusin, arabinose, and xanthotoxols (14). Furthermore, it involves phenolic compounds like catechin, gallic acid and syringic acid (15). Ficus carica leaf extract was indicated to involve rhein, chrysin and quercetin which can prevent proliferation of cancer cells, and rhein has anticancer impacts (16).…”

Section: Introductionmentioning

confidence: 99%

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Sadeghizade

Baharara

Salek

et al. 2021

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Background: Melanoma is the most serious kind of skin cancer which has significantly increased in recent decades, and the importance of its primary treatment is increased widely. Ficus carica leaves have various therapeutic impact such as anti-inflammatory, anti-proliferative and apoptotic activity. Objectives: Hence, regarding the F. carica effect on the treatment of various diseases, the present research was conducted to identify the effect of methanolic extract of F. carica leaf on apoptosis induction in B16F10 melanoma cancer cells. Methods: Cell survival was estimated by MTT assay after treatment of B16F10 cells in various concentrations of F. carica leaf extract (150, 250, 350, 450, 550, 650, 750 and 850 μg /mL) for 24 and 48 h. Cell apoptosis was analysed by AO/PI and DAPI staining, Annexin V/Propidium Iodide flow cytometry. Moreover, Real-time PCR was utilized to evaluate the expression of apoptotic genes including p53, Bax, caspase-3 and caspase-9 genes. Results: MTT assay results indicated that methanolic extract of F. carica leaf prevented the proliferation of B16F10 cells in a dose and time dependent manner. AO/PI staining results showed an elevation in apoptotic cells in treated groups and DAPI indicated that F. carica extract resulted in chromatin condensation and fragmentation. Annexin V revealed the increasing percentage of apoptotic cells after treatment. In addition, the up-regulation of apoptotic genes confirmed the apoptosis inducing potential of F. carica leaves in B16F10 cells by Real-time PCR. Conclusions: Thus, methanolic extract of F. carica leaves could be suggested as an effective anti-cancer agent for further studies on melanoma cancer.

show abstract

Ficus carica and Bone Health: A Systematic Review

Cited by 12 publications

References 50 publications

The use of medicinal plants for combating breast cancer: A comprehensive review

The use of medicinal plants for combating breast cancer: A comprehensive review

Development of Chapattis with the Whole Wheat Flour and Fig Leaves for Type II Diabetic Patients

Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

Contact Info

Product

Resources

About