Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

Hein, Estrid; Nielsen, Lene Nørby; Nielsen, Christoffer Tandrup; Munthe-Fog, Lea; Skjoedt, Mikkel‐Ole; Jacobsen, Søren; Garred, Peter

doi:10.1016/j.molimm.2014.07.003

Cited by 34 publications

(37 citation statements)

References 35 publications

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“…High plasma concentrations of H‐ficolin in SLE patients and an association to lymphopenia have been described previously , and Ucieklak et al . described an association between high levels of H‐ficolin and SLE glomerulonephritis.…”

Section: Discussionsupporting

confidence: 63%

“…There have been only few reports addressing the ficolins in relation to SLE. High serum concentrations of H-ficolin and low L-ficolin concentrations have been measured in serum from SLE patients [30,31], but only the high H-ficolin levels were confirmed in a recent report [32]. To our knowledge, there are no publications on CL-K1 or CL-L1 in SLE.…”

Section: Introductionmentioning

confidence: 94%

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Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

Troldborg

Thiel

Jensen

et al. 2015

Clinical and Experimental Immunology

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SummaryThe objective of this study was to explore the involvement of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) and other pattern recognition molecules (PRMs) of the lectin pathway of the complement system in a cross-sectional cohort of systemic lupus erythematosus (SLE) patients. Concentrations in plasma of CL-L1, CL-K1, mannan-binding lectin (MBL), M-ficolin, H-ficolin and L-ficolin were determined in 58 patients with SLE and 65 healthy controls using time-resolved immunoflourometric assays. The SLE patients' demographic, diagnostic, clinical and biochemical data and collection of plasma samples were performed prospectively during 4 months. CL-L1, CL-K1 and M-ficolin plasma concentrations were lower in SLE patients than healthy controls (P-values < 0Á001, 0Á033 and < 0Á001, respectively). H-ficolin concentration was higher in SLE patients (P < 0Á0001). CL-L1 and CL-K1 plasma concentrations in the individuals correlated in both patients and controls. Patients with low complement component 3 (C3) demonstrated a negative correlation between C3 and CL-L1 and CL-K1 (P 5 0Á022 and 0.031, respectively). Patients positive for anti-dsDNA antibodies had lower levels of MBL in plasma than patients negative for anti-dsDNA antibodies (P 5 0Á02). In a cross-sectional cohort of SLE patients, we found differences in the plasma concentrations of CL-L1, CL-K1, M-ficolin and H-ficolin compared to a group of healthy controls. Alterations in plasma concentrations of the PRMs of the lectin pathway in SLE patients and associations to key elements of the disease support the hypothesis that the lectin pathway plays a role in the pathogenesis of SLE.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 94%

Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

Troldborg

Thiel

Jensen

et al. 2015

Clinical and Experimental Immunology

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“…This is supported by a systematic review and meta‐analysis of 20 studies, where serum and plasma levels of pentraxin‐3 were found to be elevated in autoimmune and inflammatory disorders compared to normal controls . Similarly, plasma ficolin‐1 has been found to be associated with rheumatoid arthritis, but no significant difference was observed in ficolin‐1 levels between systemic lupus erythematosus patients and healthy controls …”

Section: Discussionmentioning

confidence: 81%

Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer

Rasmussen

Schultz

Gaardsting

et al. 2017

Intl Journal of Cancer

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In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin‐3, mannose‐binding lectin, ficolin‐1, ficolin‐2 and ficolin‐3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC. Patients were included from the DOC, Department of Infectious Diseases, Copenhagen University Hospital Hvidovre. Patients were given a final diagnosis based on the combined results from scans, blood work and physical examination. Weight loss, Charlson score and previous cancer were registered on admission, and plasma concentrations of biomarkers were measured. The primary outcome was incident cancer within 1 year. Out of 197 patients included, 39 patients (19.8%) were diagnosed with cancer. Patients with cancer were significantly older and had a higher burden of comorbidities and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C‐reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow‐up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs investigated nor self‐reported weight loss was associated with cancer. In this study, previous cancer, CRP and suPAR were significantly associated with cancer diagnosis in patients with NSSC. Ficolin‐1‐3, MBL and pentraxin‐3 were not associated with cancer.

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“…Lectin pathway utilises 5 different recognition subcomponents such us mannose-binding lectin, ficolins 1, 2, and 3, and collectin-11. It will be an interesting task of future studies to tackle if additional lectin-recognition molecules including ficolins (Hein et al, 2015) and collectin-11 (Farrar et al, 2016) are also contributing to the development of secondary TMAs, and if specific inhibition of MBLassociated proteases has any clinical advantage in this disease. Finally, the strong, inverse correlation between Factor H level (an important regulator of alternative pathway), and between relative ADAMTS13 deficiency is surprising, and might have important implications regarding the observed alternative pathway activation and dysregulation (decreased alternative pathway activity, together with low Factor B levels and increased C3a concentrations).…”

Section: Figmentioning

confidence: 99%

Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies

et al. 2017

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Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

Cited by 34 publications

References 35 publications

Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer

Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies

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