2015
DOI: 10.1016/j.molimm.2014.07.003
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Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

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Cited by 34 publications
(37 citation statements)
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“…High plasma concentrations of H‐ficolin in SLE patients and an association to lymphopenia have been described previously , and Ucieklak et al . described an association between high levels of H‐ficolin and SLE glomerulonephritis.…”
Section: Discussionsupporting
confidence: 63%
See 1 more Smart Citation
“…High plasma concentrations of H‐ficolin in SLE patients and an association to lymphopenia have been described previously , and Ucieklak et al . described an association between high levels of H‐ficolin and SLE glomerulonephritis.…”
Section: Discussionsupporting
confidence: 63%
“…There have been only few reports addressing the ficolins in relation to SLE. High serum concentrations of H-ficolin and low L-ficolin concentrations have been measured in serum from SLE patients [30,31], but only the high H-ficolin levels were confirmed in a recent report [32]. To our knowledge, there are no publications on CL-K1 or CL-L1 in SLE.…”
Section: Introductionmentioning
confidence: 94%
“…This is supported by a systematic review and meta‐analysis of 20 studies, where serum and plasma levels of pentraxin‐3 were found to be elevated in autoimmune and inflammatory disorders compared to normal controls . Similarly, plasma ficolin‐1 has been found to be associated with rheumatoid arthritis, but no significant difference was observed in ficolin‐1 levels between systemic lupus erythematosus patients and healthy controls …”
Section: Discussionmentioning
confidence: 81%
“…Lectin pathway utilises 5 different recognition subcomponents such us mannose-binding lectin, ficolins 1, 2, and 3, and collectin-11. It will be an interesting task of future studies to tackle if additional lectin-recognition molecules including ficolins (Hein et al, 2015) and collectin-11 (Farrar et al, 2016) are also contributing to the development of secondary TMAs, and if specific inhibition of MBLassociated proteases has any clinical advantage in this disease. Finally, the strong, inverse correlation between Factor H level (an important regulator of alternative pathway), and between relative ADAMTS13 deficiency is surprising, and might have important implications regarding the observed alternative pathway activation and dysregulation (decreased alternative pathway activity, together with low Factor B levels and increased C3a concentrations).…”
Section: Figmentioning
confidence: 99%