Fibulins: a new biomarker for pulmonary thromboembolism?

Acat, Murat; Dikiş, Özlem Şengören; Dülger, Seyhan; Akbay, Ertan; Karakaya, Ekrem; Haskul, Ismail; Chouseın, Efsun Gonca Uğur

doi:10.1080/13685538.2018.1542674

Cited by 4 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the differential diagnosis of PTE and pulmonary infection cannot usually be achieved through basic radiological examinations or classical laboratory examinations. In recent years, studies have found that the occurrence, development, and prognosis of PTE are closely related to changes in the body's inflammatory indicators [ 12 ]. Therefore, it is necessary to further understand the clinical characteristics of inflammatory indicators in PTE patients, improve the diagnosis awareness and differential diagnosis ability of PTE, achieve early diagnosis and treatment, and reduce the mortality of patients [ 13 ].…”

Section: Related Workmentioning

confidence: 99%

Clinical Characteristics of Patients with Pulmonary Thromboembolism Based on Computer Statistical Analysis

Wang

Jia

Pang

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

In order to explore the reliable clinical characteristics of patients with pulmonary thromboembolism, this paper applies computer statistical analysis methods to the analysis of clinical characteristics of patients with pulmonary thromboembolism. Moreover, starting from the actual situation, this paper combines experiments to study the case, uses sample screening and sample processing to group samples freely, and conducts grouping reliability research through data statistics methods. After verifying the reliability of the grouping, this paper combines the samples to test the effectiveness of the computer statistical analysis method applied to the clinical characteristic analysis of patients with pulmonary thromboembolism and conducts numerical analysis in combination with the comparative analysis method. The results of the research show that the computer statistical method proposed in this paper has a good effect on the clinical characteristics of patients with pulmonary thromboembolism and meets the actual needs of clinical analysis.

show abstract

Section: Related Workmentioning

confidence: 99%

Clinical Characteristics of Patients with Pulmonary Thromboembolism Based on Computer Statistical Analysis

Wang

Jia

Pang

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…FBLN5 is a protein that belongs to the fibulin family of extracellular matrix proteins; however, its role in coagulation is not fully understood. Recent studies have suggested that FBLN5 may play a role in thrombosis and pulmonary embolism [ 29 , 30 ]. FBLN5 has been shown to interact with vWF, and it may modulate the activity of vWF in the coagulation cascade and vascular injury [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 increases extracorporeal coagulation during hemodialysis associated with upregulation of vWF/FBLN5 signaling in patients with severe/critical symptoms

Yang,

Shan,

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

Background COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, but the underlying mechanism remains unclear. This study aimed to investigate the effect and mechanism of COVID-19 on the risk of extracorporeal coagulation in patients with chronic kidney disease undergoing hemodialysis. Methods A retrospective analysis of the extracorporeal coagulation status of 339 hemodialysis patients at our center before and after COVID-19 infection was performed, including subgroup analyses. Post-infection blood composition was analyzed by protein spectrometry and ELISA. Results Compared to the pre-COVID-19 infection period, COVID-19-induced extracorporeal coagulation predominantly occurred in patients with severe/critical symptoms. Further proteomic analysis demonstrated that in patients with severe/critical symptoms, the coagulation cascade reaction, platelet activation, inflammation, and oxidative stress-related pathways were significantly amplified compared to those in patients with no/mild symptoms. Notably, the vWF/FBLN5 pathway, which is associated with inflammation, vascular injury, and coagulation, was significantly upregulated. Conclusions Patients with severe/critical COVID-19 symptoms are at a higher risk of extracorporeal coagulation during hemodialysis, which is associated with the upregulation of the vWF/FBLN5 signaling pathway. These findings highlight the importance of early anticoagulant therapy initiation in COVID-19 patients with severe/critical symptoms, particularly those undergoing hemodialysis. Additionally, vWF/FBLN5 upregulation may be a novel mechanism for virus-associated thrombosis/coagulation.

show abstract

“…The AUC value stated in the study was 0.853 (95% CI 0.648-1.057) [22]. Apelin, fibulins, haemopexin, a2-macroglobulin, Ig a1-chain C region, TNF-α, HMGB1, neutrophil-to-lymphocyte ratio and albumin are among the other biomarkers whose effectiveness has been investigated in the diagnosis of pulmonary embolism [21][22][23][24][25][26]. miRNA studies on this subject have stated that these new methods and technologies can be deployed to discover new specific clinical diagnosis and risk stratification biomarkers, diagnostic schedules, and treatment protocols for pulmonary embolism [27,28].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study

et al. 2022

View full text Add to dashboard Cite

Background This study aims to investigate the diagnostic accuracy of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE). Methods Patients admitted to the emergency department of a tertiary health centre between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with (PE) and compared with that of healthy volunteers. Receiver operating characteristic analysis was performed with the obtained data, and the area under the curve (AUC) with a 95% confidence interval was determined. The parameters of diagnostic accuracy for PE were determined. Results A total of 57 participants were included in the study (28 controls and 29 PE patients). The mean adropin level in the PE group was 187.33 ± 62.40 pg/ml, which was significantly lower than that in the control group (524.06 ± 421.68 pg/ml) (p < 0.001). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Conclusion Our results suggest that adropin may be considered for further study as a candidate marker for the exclusion of the diagnosis of PE. However, more research is required to verify and support the generalizability of our study results.

show abstract

Fibulins: a new biomarker for pulmonary thromboembolism?

Cited by 4 publications

References 29 publications

Clinical Characteristics of Patients with Pulmonary Thromboembolism Based on Computer Statistical Analysis

Clinical Characteristics of Patients with Pulmonary Thromboembolism Based on Computer Statistical Analysis

COVID-19 increases extracorporeal coagulation during hemodialysis associated with upregulation of vWF/FBLN5 signaling in patients with severe/critical symptoms

Diagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study

Contact Info

Product

Resources

About