Fibrous hyperplasia of the gingiva: A side effect of cyclosporin A therapy

Proteomic Analysis in Cyclosporin A-Induced Overgrowth of Human Gingival Fibroblasts

“…The analyzed protein spots were all those which displayed the differential changes over two-fold of protein, suggesting that those proteins were closely related to the effects of CsA treatment in HGF. The identified proteins in the present study were fallen into three functional categories: [1] proliferation associated proteins, including eEF, Rho GDIa, galectin-3 and Cathepsin D, which were upregulated, whereas ANXA 2 was downregulated; [2] the metabolism associated protein, including bphosphogluconolactonase, acetyl-CoA C-acetyltransferase, aldolase A protein and translation elongation factor 1, which were upregulated, whereas Esterase D was downregulated; [3] oxidation associated proteins, including prx 1 and glutathione-S-transferase omega were upregulated.…”

“…5) Moreover, some previous studies have demonstrated that CsA stimulates the proliferation of human gingival fibroblasts (HGF). 3,12) On the other hand, there has been still controversy over the pathology of CsAGO with conflicting reports as to whether it represents a true hyperplasia. It would appear that CsA has the potential to alter the metabolism HGF in several ways.…”

A clinical review of drug‐induced gingival overgrowths

“…Gingival overgrowth was first noticed with Cs therapy in the initial human trials of the drug 36,38 but was described in the dental literature in 1983 by both Rateitschak-Plüss and cowo r k e rs 3 7 a n d Wysocki et al 39 Cs gingival overgrowth is clinically indistinguishable from that associated with PHT. The overgrowth, which normally begins at the interdental papillae, is more common in the anterior segments of the mouth and on labial surfaces of the teeth (Fig 2b).…”

“…However, others have reported overgrowth only in patients taking Cs for more than three months. 39 A randomized placebo controlled study 47 found that patients with gingival overgrowth were significantly younger than those without overgrowth.This finding was in agreement with others 44,48 and is consistent with anecdotal reports. A recent report in children indicated a 100 per cent prevalence of overgrowth in subjects taking Cs for longer than three months.…”

Involvement of apoptotic signals in cyclosporin A-induced proliferation of human gingival fibroblast

“…Unfortunately, clinical use of CsA is often associated with side effects including hepatoxicity, nephrotoxicity, neurotoxicity, hypertension and gingival overgrowth 2,3) . The occurrence of CsA-induced gingival overgrowth(CsAGO) is highly variable, but regularly appears in more than 70% of adult transplant recipient 4) .…”