Fibrous dysplasia localized to spine: a diagnostic dilemma

Gogia, Nidhi; Marwaha, Vishal; Atri, Surinder Kumar; Gulati, Manpreet Singh; Gupta, Rajiva

doi:10.1007/s00256-006-0102-8

Cited by 19 publications

(14 citation statements)

References 11 publications

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“…Fibrous dysplasia affecting the vertebrae is very unusual [1,3,4,7,8]. Dahlin and Unni found only two cases of vertebral involvement out of 418 cases reviewed [3].…”

Section: Discussionmentioning

confidence: 99%

“…Polyostotic form of the disease occurs more frequently than the monostotic form and usually involves bones of the pelvis, femur, tibia, ribs, calvarium and the facial bones. Vertebral involvement in both types is extremely uncommon [1][2][3][4][5]. In a typical case of polyostotic disease involving multiple bones of the axial skeleton with or without clinical stigmata of the disease, the presence of disease in a single or multiple vertebrae may not pose a diagnostic problem.…”

Section: Introductionmentioning

confidence: 99%

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Isolated polyostotic fibrous dysplasia of the spine: A diagnostic challenge

Mohan¹,

Unni²,

Batra³

et al. 2014

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.

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“…Fibrous dysplasia affecting the vertebrae is very unusual [1,3,4,7,8]. Dahlin and Unni found only two cases of vertebral involvement out of 418 cases reviewed [3].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolated polyostotic fibrous dysplasia of the spine: A diagnostic challenge

Mohan¹,

Unni²,

Batra³

et al. 2014

IJCRI

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“…although axial bones are more often involved in the polyostotic form [5]. Of the cases examined in this study, nine included patients with polyostotic FD, of whom one had an isolated spinal localisation.…”

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

“…FD did not consistently show hypointense signal intensities on T 1 and T 2 weighted MR images, although most radiologists are of the opinion that FD is likely to show decreased signal intensity within the lesion owing to the fibrous tissue [22,23]. Gogia et al [5] stated that the MRI characteristics of FD are variable, typically showing a signal intensity that is intermediate to low on T 1 weighted images and intermediate to high on T 2 weighted images. In our study, MRI findings of spinal FD were non-specific.…”

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

“…Fibrous dysplasia (FD) is a developmental defect of osteoblastic differentiation and bone maturation of unknown origin [1]. FD may affect the skeleton either in isolation (monostotic FD, rate, 70-80%; and polyostotic FD, rate, 20-30%) or in variable combination with endocrine and cutaneous abnormalities (McCune-Albright syndrome) [2][3][4][5]. Although patients afflicted with FD may present at any age, they are typically young and in the first and second decades of life [6].…”

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confidence: 99%

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CT and MRI of fibrous dysplasia of the spine

Park¹,

Lee²,

Choi³

et al. 2012

BJR

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Objectives: The purpose of this study was to present the CT and MRI findings of patients with fibrous dysplasia (FD) of the spine. Methods: Among the patients with pathologically proven skeletal FD, 12 (8 males and 4 females; mean age, 43 years) who were evaluated with either spine CT or MRI were included. The number and location of the involved vertebral segments, the presence of lytic lesions, ground-glass opacity (GGO), an expansile nature, cortical disruption, a sclerotic rim, a decrease in body height and contour deformity were examined on CT scans (n512), while signal intensity, enhancement patterns and the presence of a dark signal rim on the lesion were examined using MRI (n59). Results: Nine patients had polyostotic FD, including one with an isolated spinal localisation, while three had monostotic FD. An expansile nature (n53) and osteolytic lesions with GGO (n53) were seen. On CT images, GGO was noted in all patients. An expansile nature (n511) and presence of lytic lesions (n511) were noted. A decrease in body height (n59) and sclerotic rim formation (n59) were indicated. Contour deformities were visible in six patients. The MRI findings were non-specific. Dark signal rims were visible on MRI in seven patients. Conclusion: Typical imaging findings of extraspinal FD were noted on spine CT scans. These characteristic CT imaging findings of spinal FD may be helpful in differentiating FD from other common spine diseases. Fibrous dysplasia (FD) is a developmental defect of osteoblastic differentiation and bone maturation of unknown origin [1]. FD may affect the skeleton either in isolation (monostotic FD, rate, 70-80%; and polyostotic FD, rate, 20-30%) or in variable combination with endocrine and cutaneous abnormalities (McCune-Albright syndrome) [2][3][4][5]. Although patients afflicted with FD may present at any age, they are typically young and in the first and second decades of life [6]. After puberty, dysplastic areas rarely expand [7]. In general, the progression of the skeletal lesions tends to be exhausted once patients have reached adult age [7]. The diagnosis of FD is difficult in adult patients because cases in older patients, especially those involving the spine, are rare.FD represents approximately 7% of all benign tumourlike bone lesions [8]. However, the spine is affected in only 2.5% of cases, and FD of the spine is very rarely observed without there being disease elsewhere in the body [9]. Spinal involvement occurs mostly in the polyostotic form of FD; it is unusual for it to occur in the monostotic form [9,10]. When present in the elderly with multiple vertebral lesions, a biopsy may be indicated because metastatic disease or multiple myeloma may simulate a benign non-aggressive process. Therefore, active diagnosis and radiological familiarity of spinal FD are thought to be essential for preventing unnecessary examinations or procedures.The purpose of this study was to present the CT and MRI findings of spinal FD, which is rare, and to assess the efficacy of CT in the diagnosis of FD. Me...

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