Fibrous Dysplasia in Paranasal Cavities

Simović, Stjepan; Klapan, Ivica; Bumber, Željko; Bura, Miljenko

doi:10.1159/000276797

Cited by 17 publications

(11 citation statements)

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“…Craniofacial FD is usually unilateral, and the maxilla is the most commonly involved site in this region. [8][9][10] The frontal process of the maxilla was unilaterally affected in our series. This may also provide further evidence for our above-mentioned hypothesis.…”

Section: Discussionmentioning

confidence: 52%

“…The radiographic appearances may depend on the phase of development and amount of fibrous tissue and woven bone within the entity. [8][9][10] On the basis of the features of the craniofacial bones on radiographs, Fries 7 classified FD into 3 patterns: pagetoid, sclerotic, and cyst-like. In the present study, we adopted this classification scheme to analyze our cases.…”

Section: Discussionmentioning

confidence: 99%

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Fibrous Dysplasia-Like Appearance of the Frontal Process of the Maxilla on CT: Prevalence in North China

Yang¹,

Wang²,

Wang³

et al. 2011

AJNR Am J Neuroradiol

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SUMMARY:The frontal process of the maxilla occasionally shows a localized FD-like appearance. The purpose of this study was to determine its prevalence and findings on CT. A retrospective study of 1000 consecutive paranasal sinus CT scans was preformed on outpatients without a history of trauma or previous surgery in our hospital during 6 months. CT images were interpreted independently by 2 experienced head and neck radiologists on a PACS system in a bone window setting. Of the 1000 patients (546 males; 454 females), 51 (5.1%,41 males and 10 females) had an FD-like appearance in the frontal process of the maxilla. There was a statistically significant difference between sexes (P Ͻ .001). Twenty-nine (56.9%) entities arose from the right frontal process and 22 (43.1%) from the left frontal process. These entities, with well-defined margins, were located at the base of the frontal process of the maxilla, appearing as an ovoid or triangular configuration on axial-plane CT and as a spindle or elliptic shape on the coronal plane. The mean maximal diameter was 9.8 mm (range, 3.6 -16.1 mm). These entities exhibited a pagetoid appearance (type I) in 37 (72.5%), a ground-glass appearance (type II) in 8 (15.7%), and a cyst-like appearance (type III) in 6 (11.8%) patients on CT. The FD-like appearance of the frontal process of the maxilla is not rare and can be readily detected by CT. ABBREVIATIONS: FD ϭ fibrous dysplasia During the past 10 years, we have incidentally encountered a few people with an FD-like appearance of the frontal process of the maxilla by paranasal sinus CT in our daily practice. These individuals usually presented to the ear, nose, and throat clinic with rhinosinusitis symptoms and underwent paranasal sinus CT scans. On the basis of outpatient medical records, they had no facial deformities on physical examination. To the best of our knowledge, no relevant studies on the subject have been reported in the literature to date.1-6 Knowledge of the osseous appearance in this region could help radiologists and clinicians increase their awareness of the variant or asymptomatic FD, avoiding confusion with tumor or infection. For us, there has been some recent interest in the appearance of the frontal process of the maxilla. This prompted our study to determine the prevalence and features of it on paranasal sinus CT scans of outpatients in North China. Materials and Methods PatientsThis study was approved by the institutional review board. A retrospective review of paranasal sinus CT scans of 1000 consecutive outpatients who were consecutively selected by a PACS system in our hospital between August 1, 2008, and January 31, 2009, was performed. All these patients were referred for CT due to clinical symptoms, presumably rhinosinusitis. Their clinical medical records were reviewed, and they had no history of trauma or prior surgery. CT TechniqueCT images were acquired in both the axial and coronal planes by using a Brilliance 64-section CT scanner (Philips Healthcare, Best, the Netherlands). The imaging parame...

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Fibrous Dysplasia-Like Appearance of the Frontal Process of the Maxilla on CT: Prevalence in North China

Yang¹,

Wang²,

Wang³

et al. 2011

AJNR Am J Neuroradiol

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“…Cortes sagitales de TCCB, mostrando imágenes compatibles con DF en región de seno maxilar derecho. sos (Bibby & McFadzean, 1994;Simovic et al, 1996;Carreto Sanchez et al;Carmen Sampériz et al).…”

Section: Discussionunclassified

Displasia Fibrosa Monostótica Craneofacial: ¿Cómo Debe Ser el Diagnóstico?

Alves

2013

Int. J. Odontostomat.

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ALVES, N. Displasia fibrosa monostótica craneofacial: ¿cómo debe ser el diagnóstico? Int. J. Odontostomat., 7(2):221-224, 2013. RESUMEN:La displasia fibrosa (DF) es una patología benigna rara, generalmente asintomática, que afecta el tejido óseo. Debido al remplazo gradual del tejido óseo por tejido conectivo amorfo se pueden producir alteraciones óseas esté-ticas y funcionales. En este artículo se realiza una revisión de la literatura sobre la DF y se relata un caso clínico de una mujer de 49 años de edad que presenta deformidad facial debida al crecimiento lento y progresivo del maxilar derecho. Con esto pretendemos ofrecer una secuencia diagnóstica para establecer el diagnóstico definitivo de la DF monostótica, brindando los principios básicos para el manejo adecuado de los pacientes que sufren de esta enfermedad.PALABRAS CLAVE: displasia fibrosa monostótica, anomalías maxilomandibulares, tomografía computarizada cone-beam. INTRODUCCIÓNLa displasia fibrosa (DF) es una enfermedad rara, que afecta el tejido óseo. Se trata de una patología benigna, caracterizada por el remplazo de tejido óseo por tejido conectivo amorfo, lo que puede resultar en alteraciones estéticas y funcionales. Suele ser asintomática, aunque a veces por su localización, puede determinar múltiples síntomas. La DF puede afectar un hueso (monostótica) o varios huesos (poliostótica), siendo más común su manifestación en la infancia o al inicio de la adolescencia (Lichtenstein & Jaffe, 1942). La DF poliostótica relacionase con puberdad temprana y áreas de pigmentación cutánea (McCune, 1936;Albright et al., 1937). Su etiología es debida a un desequilibrio en la función de las células osteogénicas, las lesiones aparecen por una mutación que activa la subunidad a, que codifica la proteína G en las células osteoblásticas y produce una matriz ósea fibrosa desorganizada (Cohen & Howell, 1999). Otros autores plantean que puede ser una reacción anormal del hueso a un episodio traumático local o un desorden endocrino que se manifiesta como una condición ósea focal (Regezi & Sciubba, 2000).La DF se caracteriza por un aumento lento y deformante del hueso comprometido, siendo que en la variedad más frecuente, que es la monostótica, son los maxilares los huesos más afectados, seguidos por las costillas y el fémur. Otros huesos del cráneo pueden estar comprometidos, como el temporal, el etmoides y el esfenoides, esta variedad es conocida como displasia fibrosa craneofacial (DFCF) (Regezi & Sciubba;Ricalde & Horswell, 2001). Radiográficamente las lesiones de DF se caracterizan por un aspecto de vidrio deslustrado de límites mal definidos, debido a la mezcla de elementos óseos y fibrosos. Puede ser unilocular o multilocular y muchas veces está asociada con expansión de la cortical ósea. El mejor método para identificar la DFCF es la tomografía computarizada ya que permite determinar la localización y extensión de la lesión, auxilia en la planificación del tratamiento y en el procedimiento quirúrgico (Regezi & Sciubba). REPORTE DEL CASOPaciente de sexo femenino,...

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“…9 Fibrous dysplasia is commonly seen before the age of 20 years and affects maxilla and mandible with ground glass appearance on X-ray. 10 Juvenile nasopharyngeal angiofibroma is a highly vascular bengin tumor of the nasopharynx and occurs between 8 -17 years of age, exclusively in males. 11 Among the malignant neoplasms, 85% are squamous cell carcinoma 12 , of which 60% are seen in the maxilla, 30% in the nasal cavity, while 10% involve the ethmoid sinus.…”

Section: Introductionmentioning

confidence: 99%

Unilateral Nasal Obstruction Caused By Sino-Nasal Neoplastic Lesions

2006

J Liaquat Uni Med Health Sci

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OBJECTIVE: To report pattern of unilateral nasal obstruction caused by sino-nasal neoplasms seen in two teaching hospitals in Sindh, Pakistan. DESIGN: A case series. SETTING: Ear, Nose and Throat (ENT) departments of Jinnah Postgraduate Medical Centre, Karachi and People's Medical College, Nawabshah between June 1995 to June 1998. METHODS: This study included 51 patients who presented with unilateral nasal obstruction persistantly for more than eight weeks. A proforma was designed to note the complaints, pinpoint the cause and look at the outcome of the treatment and prognosis. Thus, a detailed history of patients was undertaken through clinical examination, laboratory investigations e.g. blood profile, urine analysis, radiological (common and special) imaging, biopsy and histopathology. RESULTS: Neoplastic lesions of the nose and paranasal sinuses were found in 51 patients. This included 16 (31.37%) females and 35 (68.62%) males with an average age of 37 years. Benign lesions were 19 (37.25%) and 32 (62.75%) were malignant including single case of schwanoma, two cases of squamous papilloma and three patients with fibrous dysplasia while inverted papilloma was seen in six and nasopharyngeal angiofibroma in seven patients. Commonest malignant lesion was squamous cell carcinoma seen in 30 (58.82%) patients. Maxillary sinus was involved in 30 cases and 2 of them were arising from the ethmoid sinus and nasal cavity, and were found to be adenocarcinoma. For benign lesions, wide surgical approach was adopted and except one case of inverted papilloma which reccurred, rest were cured completely. Radical and oncologically sound surgical resection combined with radiation therapy remained the treatment of choice for all the malignant lesions. Local recurrence was seen in two cases. Only one patient died after 8 months due to distant metastasis. Two patients were lost to follow up after 25 months. CONCLUSION: Neoplastic lesions especially the benign tumors, promptly treated via wide surgical approach, mostly cure the lesion with negligible complication or no recurrence. Malignant lesions of the nose and sinuses are very often diagnosed in advanced T-stages (intracranial or intraorbital extentions) due to non-specific symptoms and have a poor overall prognosis even in the advances in surgical techniques, radiation therapy and new chemotherapeutic agents.

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Fibrous Dysplasia in Paranasal Cavities

Cited by 17 publications

References 8 publications

Fibrous Dysplasia-Like Appearance of the Frontal Process of the Maxilla on CT: Prevalence in North China

Fibrous Dysplasia-Like Appearance of the Frontal Process of the Maxilla on CT: Prevalence in North China

Displasia Fibrosa Monostótica Craneofacial: ¿Cómo Debe Ser el Diagnóstico?

Unilateral Nasal Obstruction Caused By Sino-Nasal Neoplastic Lesions

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