Fibrosis <scp>P</scp>rogression in <scp>HCV C</scp>arriers with <scp>M</scp>ild <scp>H</scp>epatitis <scp>W</scp>ho <scp>P</scp>ossess the <scp>H</scp>igh‐<scp>R</scp>epetition <scp>V</scp>ariant of the <scp>DRD</scp>4 <scp>G</scp>ene, a <scp>G</scp>enetic <scp>M</scp>arker for <scp>B</scp>inge‐<scp>D</scp>rinking and <scp>R</scp>isk‐<scp>S</scp>eeking <scp>B</scp>ehavior: <scp>A L</scp>ongitudinal <scp>S</scp>tudy

Minisini, Rosalba; Boccato, E.; Favretto, Serena; Alaimo, E.; Smirne, Carlo; Burlone, Michela Emma; Bocchetta, Simone; Vandelli, C.; Colletta, C.; Colletta, Alessandro; Pirisi, Mario

doi:10.1111/acer.12047

Cited by 2 publications

(1 citation statement)

References 28 publications

(30 reference statements)

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“…The results of the genetic analysis demonstrated no association between the presence of the 7 repeat allele in the DRD4 gene and higher cigarette consumption, or among those patients with a diagnosis of COPD secondary to smoking where nicotine addiction (evaluated by Fagerström test) was higher. The frequencies of the short (S) and long (L) alleles in the study population were similar to the rest of the populations previously reported in the literature [10,[22][23][24][25].…”

Section: Discussionsupporting

confidence: 88%

The VNTR 48 bp Polymorphism in the DRD4 Gene Is Associated with Higher Tobacco Smoking in Male Mexican Mestizo Smokers with and without COPD

et al. 2019

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Cigarette smoking is influenced by nicotine’s effects on dopaminergic activity, which appear to be moderated by genetic variation, particularly a variable number tandem repeat (VNTR, 48 bp) polymorphism in the third exon of the dopamine receptor gene (DRD4). Smokers with the VNTR ≥7 repeats (long, L allele) report markedly increased participation in some smoking behaviors; hence, our aim was to evaluate the association of the L allele in Mexican Mestizo smokers with and without COPD. The DRD4 VNTR 48 bp was genotyped in 492 Mexican Mestizo smokers: 164 COPD patients (≥20 cigarettes per day, cpd), 164 heavy smokers without COPD (HS, ≥20 cpd) and 164 light smokers without COPD (LS, 1–10 cpd). In the dominant model analysis (SL + LL vs. SS), men in the COPD and HS groups showed a statistical difference compared to LS (p = 0.01, OR = 2.06, CI 95% 1.17–3.64 and p = 0.05, OR = 1.88, CI 95% 1.03–3.45, respectively). In addition, by clustering smokers >20 cpd (COPD + HS) and comparing with the LS group, we found an association with increased risk of higher tobacco smoking p = 0.01, OR = 1.99, CI 95% 1.18–3.34. In conclusion, the long allele (L) in the VNTR of the DRD4 gene is associated with the risk of presenting higher tobacco smoking in male Mexican Mestizo smokers.

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Section: Discussionsupporting

confidence: 88%

The VNTR 48 bp Polymorphism in the DRD4 Gene Is Associated with Higher Tobacco Smoking in Male Mexican Mestizo Smokers with and without COPD

et al. 2019

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Dopamine in the regulation of glucose and lipid metabolism: a narrative review

Li,

Zheng,

Wang

et al. 2024

Obesity

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ObjectiveOwing to the global obesity epidemic, understanding the regulatory mechanisms of glucose and lipid metabolism has become increasingly important. The dopaminergic system, including dopamine, dopamine receptors, dopamine transporters, and other components, is involved in numerous physiological and pathological processes. However, the mechanism of action of the dopaminergic system in glucose and lipid metabolism is poorly understood. In this review, we examine the role of the dopaminergic system in glucose and lipid metabolism.ResultsThe dopaminergic system regulates glucose and lipid metabolism through several mechanisms. It regulates various activities at the central level, including appetite control and decision‐making, which contribute to regulating body weight and energy metabolism. In the pituitary gland, dopamine inhibits prolactin production and promotes insulin secretion through dopamine receptor 2. Furthermore, it can influence various physiological components in the peripheral system, such as pancreatic β cells, glucagon‐like peptide‐1, adipocytes, hepatocytes, and muscle, by regulating insulin and glucagon secretion, glucose uptake and use, and fatty acid metabolism.ConclusionsThe role of dopamine in regulating glucose and lipid metabolism has significant implications for the physiology and pathogenesis of disease. The potential therapeutic value of dopamine lies in its effects on metabolic disorders.

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Fibrosis Progression in HCV Carriers with Mild Hepatitis Who Possess the High‐Repetition Variant of the DRD4 Gene, a Genetic Marker for Binge‐Drinking and Risk‐Seeking Behavior: A Longitudinal Study

Abstract: The link between HRV carriage and histologic outcome in a subgroup of HCV patients at low risk of progression underlines the need for intense scrutiny of alcohol habits in hepatitis C.

Cited by 2 publications

References 28 publications

The VNTR 48 bp Polymorphism in the DRD4 Gene Is Associated with Higher Tobacco Smoking in Male Mexican Mestizo Smokers with and without COPD

The VNTR 48 bp Polymorphism in the DRD4 Gene Is Associated with Higher Tobacco Smoking in Male Mexican Mestizo Smokers with and without COPD

Dopamine in the regulation of glucose and lipid metabolism: a narrative review

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