Fibrosis markers, hip fracture risk, and bone density in older adults

Barzilay, Joshua I.; Bůžková, Petra; Kizer, Jorge R.; Djoussé, Luc; Ix, Joachim H.; Fink, Howard A; Siscovick, D. S.; Cauley, Jane A.; Mukamal, Kenneth J.

doi:10.1007/s00198-015-3269-9

Cited by 7 publications

(3 citation statements)

References 15 publications

(20 reference statements)

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“…This is similar to a previous study in which the amount of collagen and cartilage exceeded the amount of immature bone tissue in the first 2 weeks of bone healing ( 27 ). Type III collagen develops in response to growth factors for the growth and healing of fractures ( 28 ). We observed a higher amount of type III collagen in the 6-week post-osteotomy groups, representing more mature bone healing, compared with the 2-week post-osteotomy groups.…”

Section: Discussionmentioning

confidence: 99%

Analysis of fracture healing in osteopenic bone caused by disuse: experimental study

Paiva

Yanagihara

Macedo

et al. 2016

Braz J Med Biol Res

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Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture healing has been investigated in several previous studies because there is still controversy over the effect osteoporosis has on the healing process. The current study aimed to analyze two different periods of bone healing in normal and osteopenic rats. Sixty, 7-week-old female Wistar rats were randomly divided into four groups: unrestricted and immobilized for 2 weeks after osteotomy (OU2), suspended and immobilized for 2 weeks after osteotomy (OS2), unrestricted and immobilized for 6 weeks after osteotomy (OU6), and suspended and immobilized for 6 weeks after osteotomy (OS6). Osteotomy was performed in the middle third of the right tibia 21 days after tail suspension, when the osteopenic condition was already set. The fractured limb was then immobilized by orthosis. Tibias were collected 2 and 6 weeks after osteotomy, and were analyzed by bone densitometry, mechanical testing, and histomorphometry. Bone mineral density values from bony calluses were significantly lower in the 2-week post-osteotomy groups compared with the 6-week post-osteotomy groups (multivariate general linear model analysis, P<0.000). Similarly, the mechanical properties showed that animals had stronger bones 6 weeks after osteotomy compared with 2 weeks after osteotomy (multivariate general linear model analysis, P<0.000). Histomorphometry indicated gradual bone healing. Results showed that osteopenia did not influence the bone healing process, and that time was an independent determinant factor regardless of whether the fracture was osteopenic. This suggests that the body is able to compensate for the negative effects of suspension.

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Section: Discussionmentioning

confidence: 99%

Analysis of fracture healing in osteopenic bone caused by disuse: experimental study

Paiva

Yanagihara

Macedo

et al. 2016

Braz J Med Biol Res

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“…Plasma levels of CML (an advanced glycation end product) were used as a measure of oxidative stress [17]. Procollagen type III N-terminal pro-peptide (PIIINP) was evaluated as a measure of systemic fibrosis [28].…”

Section: Methodsmentioning

confidence: 99%

Higher albumin:creatinine ratio and lower estimated glomerular filtration rate are potential risk factors for decline of physical performance in the elderly: the Cardiovascular Health Study

Bůžková

Barzilay

Fink

et al. 2019

Clinical Kidney Journal

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IntroductionMildly reduced renal function and elevated urine protein levels are each prospectively associated with hip fracture risk in older adults. Here we determine whether these markers are associated with reduced appendicular muscle performance.MethodsWe prospectively examined the associations of urine albumin:creatinine ratio (ACR) and reduced estimated glomerular filtration rate (eGFR) with longitudinal changes in grip strength and gait speed >2 years in 2317 older community-dwelling men and women (median age 77 years). The median ACR was 9.8 [interquartile range (IQR) 5.40–21.50] mg/g creatinine and the median eGFR was 71.6 (IQR 59.1–83.56) mL/min/1.73 m2. Models were adjusted for demographic factors, clinical history and biochemical measures in four candidate pathways: diabetes, oxidative stress, inflammation and fibrosis.ResultsIn demographic- and covariate-adjusted models, a 2-fold higher baseline urine ACR was associated with longitudinal changes of −0.17 kg [95% confidence interval (CI) −0.29 to −0.06) in grip strength and −1.10 cm/s (95% CI −1.67 to −0.53) gait speed per year. Corresponding estimates for a 10 mL/min/1.73 m2 lower baseline eGFR were −0.13 kg (95% CI −0.23 to −0.04) and −0.89 cm/s (95% CI −1.37 to −0.40), respectively. The associations of a 2-fold higher baseline ACR and a 10 mL/min/1.73 m2 lower baseline eGFR using cystatin C with grip strength and gait speed were equivalent to ∼1.2–1.9 additional years of age. Adjustment for covariates in candidate pathways did not attenuate these estimates.ConclusionsIn older adults, higher ACR and lower eGFR are potential risk factors for a decline of physical performance >2 years.

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“…N-terminal propeptide of type III collagen (PIIINP) accounts for the collagen III content and is considered lately as a fibrosis marker [23]. The level of PIIINP in AF patients was higher than in patients with sinus rhythm.…”

Section: Renal Function At Afmentioning

confidence: 99%

Atrial Fibrillation and Renal Dysfunction: Current State of the Problem and the Prospects of Further Study

Protasov¹,

Доржиева²,

Petuhova³

2016

Russ J Cardiol

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Fibrosis markers, hip fracture risk, and bone density in older adults

Abstract: TGF-β1 levels appear to be associated with bone-related phenotypes in a sex-specific manner. The reasons for these differences between men and women regarding TGF-β1 levels and hip fracture risk and bone density require further investigation.

Cited by 7 publications

References 15 publications

Analysis of fracture healing in osteopenic bone caused by disuse: experimental study

Analysis of fracture healing in osteopenic bone caused by disuse: experimental study

Higher albumin:creatinine ratio and lower estimated glomerular filtration rate are potential risk factors for decline of physical performance in the elderly: the Cardiovascular Health Study

Atrial Fibrillation and Renal Dysfunction: Current State of the Problem and the Prospects of Further Study

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